Results 71 to 80 of about 5,009,966 (344)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
The Elements of Flexibility for Task-Performing Systems
IEEE Access, 2023 What makes living systems flexible so that they can react quickly and adapt easily to changing environments? This question has not only engaged biologists for decades but is also of great interest to computer scientists and engineers who seek inspiration
Sebastian Mayer +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Biomimetics, 2023 The study of the human visual system not only helps to understand the mechanism of the visual system but also helps to develop visual aid systems to help the visually impaired.
Hui Wei, Jingyong Ye, Jiaqi Li, Yun Wang
doaj +1 more source
, 2012 Consider the problem when we want to construct some structure on a bounded degree graph, e.g. an almost maximum matching, and we want to decide about each edge depending only on its constant radius neighbourhood.
Csóka, Endre
core
Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim +8 more
wiley +1 more source
On minimal blocking sets of the generalized quadrangle $Q(4, q)$ [PDF]
Discrete Mathematics & Theoretical Computer Science, 2005 The generalized quadrangle $Q(4,q)$ arising from the parabolic quadric in $PG(4,q)$ always has an ovoid. It is not known whether a minimal blocking set of size smaller than $q^2 + q$ (which is not an ovoid) exists in $Q(4,q)$, $q$ odd. We present results
Miroslava Cimráková, Veerle Fack
doaj +1 more source
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
Algorithmic thermodynamics [PDF]
Mathematical Structures in Computer Science, 2012 Algorithmic entropy can be viewed as a special case of the entropy studied in statistical mechanics. This viewpoint allows us to apply many techniques developed for use in thermodynamics to the subject of algorithmic information theory. In particular, suppose we fix a universal prefix-free Turing machine and letXbe the set of programs that halt for ...
BAEZ, JOHN, STAY, MIKE
openaire +5 more sources
Packing Three-Vertex Paths in a Subcubic Graph [PDF]
Discrete Mathematics & Theoretical Computer Science, 2005 In our paper we consider the $P_3$-packing problem in subcubic graphs of different connectivity, improving earlier results of Kelmans and Mubayi. We show that there exists a $P_3$-packing of at least $\lceil 3n/4\rceil$ vertices in any connected subcubic
Adrian Kosowski +2 more
doaj +1 more source