Results 71 to 80 of about 2,274,451 (319)

Shadows of quantum machine learning

Nature Communications
Quantum machine learning is often highlighted as one of the most promising practical applications for which quantum computers could provide a computational advantage.
Sofiene Jerbi, Casper Gyurik, Simon C. Marshall, Riccardo Molteni, Vedran Dunjko   +4 more
doaj   +1 more source

Certifying algorithms

Computer Science Review, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
McConnell, R M, Mehlhorn, Kurt, Naher, S, Schweitzer, Pascal   +3 more
openaire   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Evaluating the Alzheimer's disease data landscape

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction Numerous studies have collected Alzheimer's disease (AD) cohort data sets. To achieve reproducible, robust results in data‐driven approaches, an evaluation of the present data landscape is vital.
Colin Birkenbihl, Yasamin Salimi, Daniel Domingo‐Fernándéz, Simon Lovestone, AddNeuroMed consortium, Holger Fröhlich, Martin Hofmann‐Apitius, the Japanese Alzheimer's Disease Neuroimaging Initiative, and the Alzheimer's Disease Neuroimaging Initiative   +8 more
doaj   +1 more source

Algorithmic probability

Scholarpedia, 2007
Algorithmic "Solomonoff" Probability (AP) assigns to objects an a priori probability that is in some sense universal. This prior distribution has theoretical applications in a number of areas, including inductive inference theory and the time complexity analysis of algorithms.
Hutter, M., Legg, S., Vitanyi, P.M.B.
openaire   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Three-layered semantic framework for public health intelligence

Journal of Biomedical Semantics
Background Disease surveillance systems play a crucial role in monitoring and preventing infectious diseases. However, the current landscape, primarily focused on fragmented health data, poses challenges to contextual understanding and decision-making ...
Sathvik Guru Rao, Pranitha Rokkam, Bide Zhang, Astghik Sargsyan, Abish Kaladharan, Priya Sethumadhavan, Marc Jacobs, Martin Hofmann-Apitius, Alpha Tom Kodamullil   +8 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Comparative Analysis of Photovoltaic Generating Systems Using Particle Swarm Optimization and Cuckoo Search Algorithms under Partial Shading Conditions

, 2021
Rahul Wilson Kotla, Srinivasa Rao Yarlagadda   +1 more
openalex   +2 more sources