Results 121 to 130 of about 86,425 (339)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
VALUATION OF TARGET FIRMS ACQUIRED IN THE FOOD SECTOR DURING THE 1996-2001 WAVE [PDF]
The paper studies valuation ratios of food companies that were part of mergers & acquisitions (M&A) involving at least one French company during the 1996-2001 period. Results converge to value the food company 1.1 to 1.4 times its turnover.
Declerck, Francis
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
The problem of possible conservation of the natural activity of food products is discussed. The struggle for the preservation of the natural activity of food products is an important means of preventing the unfavorable consequences of long term ...
Petrovskiy, K. S.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
On a feedback of the share of avalanche alimentation with a glacier accumulation
, 2018 Victor Popovnin, Y. Y. Sergiyevskaya
openalex +2 more sources
RVF surveillance in Mayotte: Tracking an invisible disease from the society point of view [PDF]
, 2014 Rift Valley fever circulates in Mayotte's ruminants' population since 2004 but no symptomatic case among ruminants was officially declared. An active surveillance system has been implemented but couldn't link any seroconversion with an abortion event in ...
Cardinale, Eric +7 more
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Calenda, 2004 Terrains & travaux, la revue de sciences sociales de l’Ecole Normale Supérieure de Cachan, consacre un numéro spécial à l’alimentation, à paraître en octobre 2005.
openaire +3 more sources