Results 81 to 90 of about 80,566 (281)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Sustainable Production of Medium-Chain Fatty Acids from Fresh Leachates in the District of Abidjan: Study of the Feasibility of the Process and Environmental Benefits

Fermentation
Leachate management remains a major environmental challenge, especially in rapidly urbanizing cities of developing countries. Traditionally considered toxic and useless, it is a sustainable organic resource with the potential for high-value biochemical ...
Akeyt Richmond Hervé Koffi, Alessio Campitelli, Daniel Stanojkovski, Edi Guy-Alain Serges Yapo, Alane Romaric N’guessan, Franck Orlando Yebouet, N’Dédé Théodore Djeni   +6 more
doaj   +1 more source

XV workshop "Mètodes ràpids i automatització en microbiologia alimentària" [PDF]

, 2017
Del 22 al 25 de novembre de 2016, tingué lloc el XV workshop sobre Mètodes ràpids i automatització en microbiologia alimentària (MRAMA) a la Facultat de Veterinària de la UAB, dirigit per la doctora Marta Capellas Puig i el doctor Josep Yuste Puigvert ...
Capellas Puig, Marta, Yuste Puigvert, Josep   +1 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

STUDY REGARDING QUALITY FOOD PRODUCTS ON THE ZLATNA MARKETPLACE (ALBA COUNTY) [PDF]

The present work approaches a few problems related to the quality parameters of the food products starting from the present demands of the market economy.
Dumitrel Gabriela-Alina, Glevitzky Mirel, Popa Dorin, Popa Maria, Varvara simona   +4 more
core  

Risk factors associated with Rift Valley fever epidemics in South Africa in 2008-11. [PDF]

, 2008
Rift Valley fever (RVF) is a zoonotic and vector-borne disease, mainly present in Africa, which represents a threat to human health, animal health and production. South Africa has experienced three major RVF epidemics (1950-51, 1973-75 and 2008-11).
Métras, Raphaëlle, Jewell, Chris, Porphyre, Thibaud, Thompson, Peter N, Pfeiffer, Dirk U, Collins, Lisa M, White, Richard G   +6 more
core   +5 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Langual : un langage international pour la description structurée des aliments = Langual : an international language for the structured description of foods [PDF]

, 1991
L'article traite de l'organisation des nouvelles banques de données sur la composition des aliments en s'appuyant sur l'exemple de la banque française REGAL développée au CIQUAL.
Favier, Jean-Claude, Feinberg, M., Ireland-Ripert, J.   +2 more
core