Results 111 to 120 of about 4,200 (201)

Sviluppo di un nuovo processo per la sintesi di Aliskiren [Process development of generic Aliskiren]

, 2013
A synthesis of the new-generation antihypertensive Aliskiren is described. This innovative process features an asymmetric hydrogenation to simultaneously control two of the four chiral centers and a strategic use of the Curtius ...
Rasparini M, Carcone L, Barreca G, Cini E, Taddei M, Russo A, Marras G   +6 more
core  

Structure-Based Design and In Silico Evaluation of a Lipophilic Cyclooctanoyl- Derivative as a Renin Inhibitor: Lessons from Withdrawn Aliskiren. [PDF]

Int J Mol Sci
Pavlos D, Petsas E, Chatzipieris FP, Mavromoustakos T, Chasapis CT.   +4 more
europepmc   +1 more source

Aliskiren - The first of a new class of antihypertensive

, 2016
Aliskiren is the first of a new class of orally active, non-peptide, renin inhibitors. The enzyme renin is involved in the first step of the renin - angiotensin - aldosterone system (RAAS), which helps regulate blood pressure.

core  

Renoprotective vs. Antihypertensive Dosing of Renin-Angiotensin System Inhibitors in Chronic Kidney Disease: Analysis of Summary of Product Characteristics of Medicinal Products Authorized in Poland. [PDF]

J Clin Med
Maciejczyk M, Dworakowska AM, Bujalska-Zadrożny M.   +2 more
europepmc   +1 more source

Aliskiren reduces prorenin receptor expression and activity in cultured human aortic smooth muscle cells

, 2011
The recent development of the direct renin inhibitor aliskiren provides a novel approach to inhibit the renin-angiotensin-aldosterone system (RAS) and to reduce blood pressure and its related vascular diseases including atherosclerosis.
C.M. Greco, N. Ferri, G. Maiocchi, A. Corsini   +3 more
core  

Repurposing of lansoprazole and nitazoxanide as NR2F2 inhibitors in the gastric cancer cell line GCIY: computational insights and siRNA-mediated <i>in vitro</i> tests. [PDF]

Front Chem
Culletta G, Roomi MS, Caricasulo MA, Zanetti A, Terao M, Paroni G, Garattini E, Tutone M.   +7 more
europepmc   +1 more source

Pharmacokinetics, mass balance, and metabolism of [¹⁴C]SPH3127 (sitokiren), a novel direct renin inhibitor in humans. [PDF]

Front Pharmacol
Ma S, Huang X, Yan S, Liu H, Zhang H, Zhang Y, Cui W, Ding C, Diao X, Miao L.   +9 more
europepmc   +1 more source

Aliskiren [PDF]

, 2020
openaire   +1 more source

Recommendations on antihypertensives in the peri-operative period: a reply. [PDF]

Anaesthesia
Wickham A, Hartle A, McCormack T.
europepmc   +1 more source

Effects of Inhibitors of the Activity of the Circulating Renin-Angiotensin System on the Growth and Proliferation of Endometrial Cancer Cells. [PDF]

Int J Mol Sci
Delforce SJ, Mohammed R, Symington TL, Wang Y, Verrills NM, Lumbers ER, Pringle KG.   +6 more
europepmc   +1 more source