Results 101 to 110 of about 193,702 (280)

The hidden regulators: Non‐coding RNAs in KMT2A‐rearranged acute lymphoblastic leukemia

International Journal of Cancer, EarlyView.
Abstract Acute lymphoblastic leukemia (ALL) driven by KMT2A rearrangements (KMT2A‐r) is an aggressive hematologic malignancy with poor prognosis and a high incidence in infants. While KMT2A fusion proteins drive leukemogenesis through transcriptional dysregulation, recent discoveries have highlighted the pivotal role of non‐coding RNAs (ncRNAs) in ...
Maria Augusta Poersch, Ana Carolina Rodrigues, Priscila Elias Ferreira Stricker, Alexandre Luiz Korte Azevedo, Daniel Pacheco Bruschi, Jaqueline Carvalho de Oliveira   +5 more
wiley   +1 more source

Intrapartum oral azithromycin for maternal infection prophylaxis and the risk of postpartum hemorrhage: A secondary analysis of the A‐PLUS trial

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective A single oral dose of azithromycin (AZM) given during labor to women planning a vaginal delivery reduced maternal infections including sepsis, with a stronger effect in sub‐Saharan Africa than South Asia. Since maternal infection contributes to labor dysfunction and postpartum hemorrhage (PPH), we evaluated the effect of AZM on the ...
Larissa Sidze, Janet L. Moore, Waldemar A. Carlo, Musaku Mwenechanya, Elwyn Chomba, Jennifer J. Hemingway‐Foday, Avinash Kavi, Mrityunjay C. Metgud, Shivaprasad S. Goudar, Richard Derman, Adrien L. Lokangaka, Antoinette K. Tshefu, Melissa S. Bauserman, Carl L. Bose, Poonam Shivkumar, Manjushri Waikar, Archana B. Patel, Patricia L. Hibberd, Paul Nyongesa, Fabian Esamai, Osayame A. Ekhaguere, Sherri L. Bucher, Saleem Jessani, Shiyam Sunder Tikmani, Sarah Saleem, Robert L. Goldenberg, Sk Masum Billah, Ruth Lennox, Rashidul Haque, William A. Petri, Lester Figueroa, Manolo Mazariegos, Nancy F. Krebs, Tracy L. Nolen, Marion Koso‐Thomas, Elizabeth M. McClure, Alan T. N. Tita, for the A‐PLUS Trial Group   +37 more
wiley   +1 more source

Computational design of two‐dimensional MA2Z4 family field‐effect transistor for future Ångström‐scale CMOS technology nodes

InfoMat, EarlyView.
Two‐dimensional MA2Z4 such as MoSi2N4 offer a new path to extend transistor scaling beyond the limits of silicon. Due to their exceptional properties, these 2D semiconductors are promising candidates for future Ångström‐scale CMOS technology. This review outlines the computational design and roadmap bridging materials discovery, device design and ...
Che Chen Tho, Zongmeng Yang, Shibo Fang, Shiying Guo, Liemao Cao, Chit Siong Lau, Fei Liu, Shengli Zhang, Jing Lu, L. K. Ang, Lain‐Jong Li, Yee Sin Ang   +11 more
wiley   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

Interdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li   +10 more
wiley   +1 more source

Molecular crosstalk via exosomes in lung cancer progression

Interdisciplinary Medicine, EarlyView.
“Molecular and theranostics roles of exosomes in Lung Cancer.” Abstract Exosomes play a critical role in lung cancer metastasis, facilitating tumor progression through intercellular communication between cancer cells and the tumor microenvironment. These nanosized extracellular vesicles carry bioactive molecules such as proteins, nucleic acids, and ...
Rajib Dhar, Vinoth Kumarasamy, Brian G. Oliver, Vetriselvan Subramaniyan   +3 more
wiley   +1 more source

Role of Quality of Life in Daily Functioning, Communication with Care Teams, and Treatment Decisions in Patients with ALK+ NSCLC

JTO Clinical and Research Reports
Introduction: This study investigated quality of life (QoL) and its role in treatment decision making among patients with anaplastic lymphoma kinase (ALK)+ NSCLC.
Heather Law, MA, Huamao M. Lin, PhD, Eileen Curran, PhD, Annette Szumski, MS, Jacinta Wiens, PhD, Jennifer Blender, PhD, Emily S. Venanzi, PhD, Erin L. Schenk, MD, PhD, Jessica J. Lin, MD, Jennifer C. King, PhD   +9 more
doaj   +1 more source

Adopting ALK and LTK [PDF]

Proceedings of the National Academy of Sciences, 2015
Aberrant, uncontrolled activation of receptor tyrosine kinases (RTKs) is the “original sin” of many human cancers, in that this activation can both initiate and drive the evolution of tumors (1). Mutation and overexpression of the multiple members of the epidermal growth factor/ErbB receptor family, to cite only a single example, constitute cancer ...
openaire   +2 more sources

Small Nucleotide Variant Analysis Using RNA Fusion Panel (SMURF): Making the Most of RNAseq Data in Solid Tumours

Journal of Clinical Laboratory Analysis, EarlyView.
RNA‐based fusion panels using targeted next‐generation sequencing of formalin‐fixed paraffin‐embedded (FFPE) tumour tissue specimens have been used for a few years from patients with various tumour types to detect rearrangements/fusions. Using the bioinformatic approaches the data obtained from RNA sequencing (RNAseq) can also be used for small ...
Pranav Dorwal, Julie Robin, Broden Krause, Patricia Pyrchla, Bin Yuan, Robert Quach, Anna Fong Na Goh, Pamela Htain, Noel Djitro, Amit Kumar, Liyan Song, Priscillia Siswara, Suzanne Svobodova, Peter Kaub, Beena Kumar   +14 more
wiley   +1 more source

Molecular genetic features of neuroblastoma in adolescent

Успехи молекулярной онкологии
Aim. To determin the clinical and biological features of neuroblastoma in patients over 10 years old.   Materials and methods. Patients with a histologically verified diagnosis of neuroblastoma / ganglioneuroblastoma established over the age of 10 years ...
N. A. Andreeva, T. V. Shamanskaya, D. Yu. Kachanov, R. Kh. Abasov, N. V. Gegeliya, A. E. Druy   +5 more
doaj   +1 more source

Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with the variant RNF213-, ATIC- and TPM3-ALK fusions is characterized by copy number gain of the rearranged ALK gene

Haematologica, 2017
Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma is characterized by 2p23/ALK aberrations, including the classic t(2;5)(p23;q35)/NPM1-ALK rearrangement present in ~80% of cases and several variant t(2p23/ALK) occurring in the ...
Jo-Anne van der Krogt, Marlies Vanden Bempt, Julio Finalet Ferreiro, Nicole Mentens, Kris Jacobs, Ursula Pluys, Kathleen Doms, Ellen Geerdens, Anne Uyttebroeck, Pascal Pierre, Lucienne Michaux, Timothy Devos, Peter Vandenberghe, Thomas Tousseyn, Jan Cools, Iwona Wlodarska   +15 more
doaj   +1 more source