Results 121 to 130 of about 193,702 (280)

Molecular Diagnostics in Thyroid Nodules: Current Applications, Clinical Value, and Future Perspective

Med Research, EarlyView.
ABSTRACT Molecular diagnostics have become an important adjunct to ultrasonography and fine‐needle aspiration (FNA) for thyroid nodules, especially in Bethesda III/IV cytology where malignancy risk is uncertain. This narrative review summarizes the diagnostic and prognostic value of key genomic drivers (BRAF V600E, RAS, RET, TERT, and selected fusions)
Guohui Xiao, Min Ding, Zhixue Min, Yihan Dong, Xuanye Cao, Qiang Lu, Cong Chen, Yahui Wu, Xin Guo, Zhen Wu, Jing Xie, Dan Xu, Haizhen Chen, Rongli Xie, Jian Fei   +14 more
wiley   +1 more source

The frequency of EGFR gene mutations in a cohort of Romanian patients with non-small cell lung cancer and their association with PD-L1 expression level and ALK rearrangements

Romanian Journal of Laboratory Medicine
The mortality rate linked to non-small cell lung cancer (NSCLC) has notably decreased in recent years, primarily due to refined diagnostic techniques.
Cohn Ester-Andreea, Csutak Ortansa, Tataru Ecaterina   +2 more
doaj   +1 more source

Identifying knowledge gaps about context dependency in freshwater species invasions

Oikos, EarlyView.
The abiotic template of freshwater ecosystems is being altered by human activity on a global scale, often promoting the establishment of new invasive taxa and increasing the likelihood of facilitation between invaders. These positive interactions represent a substantive threat to freshwater ecosystems by promoting the establishment and persistence of ...
Samuel F. Fritz, Lindsey K. Albertson, Benjamin B. Tumolo, José A. Sánchez‐ Ruiz, Hayley C. Oakland, Anna C. French, Johnathan Reyes de Merkle, Fritz Kalakay, Alzada Roche, Geoffrey C. Poole, Colden V. Baxter   +10 more
wiley   +1 more source

Comparable responses of immunological markers in Japanese and European subjects after SQ HDM SLIT-tablet treatment

Allergology International, 2020
Katsuyo Ohashi-Doi, Kaare Lund, Henrik Ipsen, Peter Sejr Andersen, Holger Mosbech, J. Christian Virchow, Minoru Kudo, Thomas Stranzl, Tomokazu Matsuoka   +8 more
doaj   +1 more source

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

Degree of fear of needles and preferred allergy immunotherapy treatment among children with allergic rhinitis: caregiver survey results

Frontiers in Pediatrics
IntroductionA child's fear of needles may impact the preferred route of allergy immunotherapy (AIT) when choosing between subcutaneous immunotherapy (allergy shots) or sublingual immunotherapy (SLIT). A survey was conducted to understand caregiver health-
Karen Rance, Michael Blaiss, Payel Gupta, Hendrik Nolte, Erin P. Scott, Donna D. Gardner   +5 more
doaj   +1 more source

The Evolution of Pneumocystis jirovecii Pneumonia Prophylaxis for Pediatric Patients With Extracranial Solid Tumors: A Review of Historical Insights and Future Directions

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pneumocystis jirovecii pneumonia (PJP) remains a modern‐day complication for pediatric patients receiving treatment for extracranial solid tumors (ST), highlighting the need for reconsideration of our current approach toward PJP prophylaxis. This critical review aims to evaluate both universal and risk‐stratified approaches to PJP prophylaxis ...
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Thoracic radiotherapy may enhance the survival of patients with low‐risk advanced lung adenocarcinoma based on protein biomarkers

Precision Radiation Oncology, EarlyView.
The prognosis of LUAD was significantly influenced by many clinical and protein biomarkers. A risk model was developed to help identify advanced LUAD patients who would benefit from thoracic radiotherapy, and thoracic radiotherapy just significantly improved the survival of low‐risk patients but not that of high‐risk.
Chunliu Meng, Fang Wang, Juan Wang, Jia Tian, Xue Li, Haijun Lu, Lujun Zhao, Ping Wang   +7 more
wiley   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Redefining Recovery: The Transformative Impact of the ALINA Trial on Adjuvant Therapy for ALK-Positive Non-Small Cell Lung Cancer

Lung Cancer: Targets and Therapy
Zhaohui Liao Arter,1,2 Misako Nagasaka1– 3 1Division of Hematology/Oncology, University of California Irvine School of Medicine, Orange, CA, USA; 2Chao Family Comprehensive Cancer Center, Orange, CA, USA; 3Division of Neurology, Department of Internal ...
Arter ZL, Nagasaka M
doaj