Results 61 to 70 of about 193,702 (280)

Identification of the primary sensitizing mite (dominant mite) in patients with allergic respiratory disease sensitized to Dermatophagoides pteronyssinus and Lepidoglyphus destructor

World Allergy Organization Journal
Objective: To identify the dominant mite in patients with allergic respiratory disease (ARD) and double sensitization to Dermatophagoides pteronyssinus (Dpt) and Lepidoglyphus destructor (Ld).
José Arias-Irigoyen, MD, Irene Arias-Talavera, MD, Manuel Lombardero, PhD, Agustín Galán, BSc, Rafael I. Monsalve, PhD   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

DFT-analysis of protolytic equivalents of 5-(aryl)-4-(methyl,amino)-1,2,4-triazole-3(2H)-thione

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
The use of modern computer methods in aspects of quantum chemistry and systematic analysis of their results give an idea of the reactivity of organic compounds, as well as to understand the essence of known experimental data, correct predictions, and ...
O. A. Bihdan, N. A. Alk Khalaf
doaj   +1 more source

Effects of flavor conserving CP violating phases in SUSY models

, 2000
I summarize our recent works on the effects of flavor conserving CP violating phases in SUSY models on $B$ and $K$ phenomenology.Comment: Contributed alk at the 3rd International Conference on B Physics and CP Violation (BCONF99), Taipei, Taiwan, 3-7 ...
Ko, P.
core   +1 more source

A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation. [PDF]

, 2014
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a relatively good prognosis, aggressive forms exist. We have identified a novel translocation, causing the fusion of the TRAF1 and ALK genes, in one patient ...
...], Abate, F., Abele, C., Acquaviva, A., Agostinelli, C., Aime, S., Aliberti, S., Barreca, A., Bertoni, F., Bessone, L., Boi, M., Cerchietti, L., Chan, W.C., Cheng, M., Crescenzo, R., Di Giacomo, F., Falini, B., Ficarra, E., Gaudiano, M., Inghirami, G., Iqbal, J., Kwee, I., Landra, I., Lasorsa, E., Longo, D.L., Machiorlatti, R., Messana, K., Novero, D., Pera-Gresely, B., Piccaluga, P.P., Pileri, S., Piva, R., Ponzoni, M., Rabadan, R., Rinaldi, A., Ruggeri, B., Shultz, L.D., Tabb\uf2, F., The European T-cell Lymphoma Study Group [..., Tiacci, E., Todaro, M., Tousseyn, T., Van Der Krogt, J.-A., Wlodarska, I.   +43 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Detection of tumor ALK status in neuroblastoma patients using peripheral blood

, 2015
International audienceNew protocols based on ALK-targeted therapy by crizotinib or other ALK-targeting molecules have opened for the treatment of patients with neuroblastoma (NB) if their tumors showed mutation and/or amplification of the ALK gene ...
Barone, Beaver, Bresler, Brodeur, Caren, Carpenter, Chan, Chen, Cohn, Combaret, Combaret, Combaret, Combaret, Delacour, George, Gotoh, Hindson, Janoueix-Lerosey, Janoueix-Lerosey, Janoueix-Lerosey, Kuang, Monzon, Moore, Moroz, Mosse, Mosse, Page, Sausen, Schleiermacher   +28 more
core   +3 more sources

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

The impact of moderate and severe asthma exacerbations on quality of life: a post hoc analysis of randomised controlled trial data

Journal of Patient-Reported Outcomes, 2021
Background This paper reports the duration of moderate and severe exacerbations in patients with house dust mite induced allergic asthma and the impact on patients’ quality of life.
Andrew Briggs, Shuaib Nasser, Eva Hammerby, Sarah Buchs, J. Christian Virchow   +4 more
doaj   +1 more source

Petrography and petrology of the Hawaii Scientific Drilling Project lavas: Inferences from olivine phenocryst abundances and compositions [PDF]

, 1996
The Mauna Loa (ML) and Mauna Kea (MK) lavas recovered by the Hawaii Scientific Drilling Project (HSDP) include aphyric to highly olivine-phyric basalts.
Alves, Sophie, Baker, Michael B., Stolper, Edward M.   +2 more
core   +1 more source