Results 121 to 130 of about 333,892 (266)

Bone-specific alkaline phosphatase as a marker of bone formation: Clinical and imaging correlates. [PDF]

World J Exp Med
Thirunavukkarasu PJ, Gunasekar A, Jeyaraman N, Nallakumarasamy A, Devanand V, Bharadwaj S, Jeyaraman M.   +6 more
europepmc   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

Advanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang, Jingyi Xu, Yonghong Wu, Yitong Qu, Xinglin Hu, Yuchen Sun, Yanshuang Wu, Zhonghua Liu, Jiaqiang Wang, Lei Lei   +9 more
wiley   +1 more source

Association between salivary alkaline phosphatase levels and periodontal disease: a systematic review and meta-analysis. [PDF]

BDJ Open
Alarcón-Sánchez MA, Lomelí-Martínez SM, Ortuño-Sahagún D, Becerra-Ruiz JS, Mosaddad SA, Heboyan A.   +5 more
europepmc   +1 more source

Spatiotemporal Regulation of Hierarchical Assembly of Hydroxyapatite for Enamel Remineralization

Advanced Science, EarlyView.
Biomimetic repair exhibits unique advantages for enamel regeneration compared with conventional clinical treatments. An enzymatic mineralization system (EMS) is developed, where the resulting HAP nanorods hierarchically assemble into a highly ordered structure on the enamel surface through the spatiotemporal modulation of interfacial energies of ...
Zhenhang Tang, Zhisen Zhang, Yuanyu Zhou, Wenzhi Wu, Congrui Zhao, Chang Liu, Tong Shi, Wenjing Jin, Zhaoming Liu, Weifeng Fang, Qingyun Lin, Yi He, Zhijian Xie, Ruikang Tang, Changyu Shao, Zhuo Chen   +15 more
wiley   +1 more source

Effects of TiO₂ nanoparticles on the kinetics and conformation of bovine alkaline phosphatase. [PDF]

Biochem Biophys Rep
Babaknejad N, Shareghi B, Saboury AA.
europepmc   +1 more source

Age‐Related Lamin B1 Deficiency Activates SLC7A11‐Dependent Disulfidptosis to Impair Osteogenesis via Intercepting Mitochondrial Fission

Advanced Science, EarlyView.
This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu, Qibo Li, Weihao Zhang, Guan Zheng, Junhua Chen, Yipeng Zeng, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Jiajie Lin, Zepeng Su, Zhongyu Xie   +12 more
wiley   +1 more source

Prognostic Value of Serial Alkaline Phosphatase-to-Albumin Ratio for Mortality After Transjugular Intrahepatic Portosystemic Shunt. [PDF]

Medicina (Kaunas)
Yavuz S, Comoglu E, Ari D, Ozdemir M, Comoglu M, Kayhan MA.   +5 more
europepmc   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Allopurinol and Alkaline Phosphatase Levels in Patients with Non-Dialysis CKD. [PDF]

J Clin Med
Taskapan H, Taskapan T, Bellasi A, Tam P, Sikaneta T.   +4 more
europepmc   +1 more source

Intratumoral Fusogenic Outer Membrane Vesicles Enhance Antitumor Immunity Through Tumor MHC‐I Upregulation and Tumor Bacterization

Advanced Science, EarlyView.
Tumor bacterization by fusogenic outer membrane vesicles enhances microbial‐like recognition of tumor cells while activating the TLR4–NF‐κB–NLRC5 axis to upregulate MHC class I expression. By simultaneously strengthening APC sensing and T‐cell recognition, this strategy breaks tumor immune invisibility and promotes more effective antitumor immune ...
Xing Liu, Jiaxin Zhou, Guihong Lu, Chenjing Zhao, Weixiu Wang, Jichuan Chen, Fengqi Zhang, Fan Zhang, Hai‐Yan Xie, Weidong Nie   +9 more
wiley   +1 more source