Results 131 to 140 of about 331,716 (307)
PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders
Advanced Science, EarlyView.This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu +12 morewiley +1 more sourceHepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk
Advanced Science, EarlyView.Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan +19 morewiley +1 more sourceDipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes
Advanced Science, EarlyView.By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma +11 morewiley +1 more sourceAlkaline Phosphatase
BIO-PROTOCOL, 2012 Howard R. Champion, Nova L. Panebianco, Jan J. De Waele, Lewis J. Kaplan, Manu L. N. G. Malbrain, Annie L. Slaughter, Walter L. Biffl, Clay Cothren Burlew, Ernest E. Moore, Parita Bhuva, Barnett R. Nathan, Michael E. Silverman, Richard D. Shih, Luciano Gattinoni, E. Carlesso, Pietro Caironi, Argyris Michalopoulos, Matthew E. Falagas, Angela M. Mills, Anthony J. Dean, Christopher R. Wyatt, Ernest E. Moore, Clay Cothren Burlew, Chadwick D. Miller, Karina M. Soto-Ruiz, Joseph Varon, W. Frank Peacock, Prasad Devarajan, Arun Jeyabalan, Joan R. Badia, José A. Lorente, Nicolás Nin, Ramsey J. Daher, Mark D. Okusa, Rui P. Moreno, Djillali Annane, Brenna M. Farmer, Claudio Ronco, Zaccaria Ricci, Jameel Ali, Richard D. Branson, Bryce R. H. Robinson, Lara Wijayasiri, Andrew Rhodes, Maurizio Cecconi, Stuart F. Reynolds, Peter G. Brindley, John A. Kellum, Nattachai Srisawat, Patrick D. Brophy, Michelle Baack, John A. Kellum, Nattachai Srisawat, Eric A. J. Hoste, Edward T. Dickinson, Alexander L. Colonna, J. Wayne Meredith, Ali El-Solh, Brian H. Rowe, Howard L. Corwin, Joel M. Bartfield, Joel M. Bartfield, Thomas M. Scalea, Kareem R. AbdelFattah, Joseph P. Minei, Patrick T. Murray, Caitlin W. Hicks, Peter Q. Eichacker, S. Uddin, Susanna Price, Joseph P. Lynch, Anne-Cornélie J. M. Pont, Tyler W. Barrett, Brett F. Bechtel, David F. Gaieski, Munish Goyal, Mette M. Berger, Lucas Liaudet, Pascal Vranckx, Marco Valgimigli, P. W. Serruys, Ian Loftus, Charles S. Brudney, Srini Pyati, Charles S. Brudney, Juan B. Ochoa, Mary K. Miranowski, Rebecca M. Dodson, Sandra L. Kavalukas, Adrian Barbul, Jonathan R. Egan, Marino S. Festa, Samir H. Haddad, Yaseen M. Arabi, David W. Collins, Yahya Shehabi, Steven E. Carsons, Wouter Meersseman, Daniel K. Resnick, Basheal M. Agrawal, Griet Thielen, Susanna Price +101 moreopenaire +2 more sources
