Results 151 to 160 of about 331,716 (307)

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

open access: yesAdvanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu   +9 more
wiley   +1 more source

N-linked glycosylation plays an essential role in the stability and function of tissue-nonspecific alkaline phosphatase. [PDF]

open access: yesJ Biol Chem
Atanasova D   +8 more
europepmc   +1 more source

Principles for Rigorous Design and Application of Synthetic Microbial Communities

open access: yesAdvanced Science, EarlyView.
SynComs are artificially designed to enable inter‐species metabolic interactions, metabolic division of labor, and ecological interactions that can elicit phenotypes like colonization stability and environmental adaptation. This systematic review explores the processes used to construct SynComs, the assessment of the mechanisms of metabolic interaction
Yuxiao Zhang   +21 more
wiley   +1 more source

New antidiabetic drugs of the thiazolidinediones class without inhibitory effects on alkaline phosphatase activity and matrix mineralization in mouse MC3T3-E1 osteoblasts

open access: green, 2010
Cristiane Akemi Iamamoto Saito   +7 more
openalex   +1 more source

Relative Importance of Phosphodiesterase vs. Phosphomonoesterase (Alkaline Phosphatase) Activities for Dissolved Organic Phosphorus Hydrolysis in Epi- and Mesopelagic Waters [PDF]

open access: gold, 2020
Blair Thomson   +7 more
openalex   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló   +2 more
wiley   +1 more source

Purification of alkaline phosphatase [PDF]

open access: yesBiochemical Journal, 1949
M. A. M. Abul-Fadl   +3 more
openaire   +2 more sources

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