Results 61 to 70 of about 1,105,476 (396)

TET2 inhibits differentiation of embryonic stem cells but does not overcome methylation-induced gene silencing [PDF]

, 2014
TET2 is a methylcytosine dioxygenase that is frequently mutated in myeloid malignancies, notably myelodysplasia and acute myeloid leukemia. TET2 catalyses the conversion of 5′-methylcytosine to 5′-hydroxymethylcytosine within DNA and has been implicated ...
Chevassut, Timothy, Norman, Louis, Tarrant, Paul   +2 more
core   +3 more sources

A novel psychrophilic alkaline phosphatase from the metagenome of tidal flat sediments

BMC Biotechnology, 2015
BackgroundAlkaline phosphatase (AP) catalyzes the hydrolytic cleavage of phosphate monoesters under alkaline conditions and plays important roles in microbial ecology and molecular biology applications.
Dae-Hee Lee, Su-lim Choi, Eugene Rha, Soo-Jin Kim, Soo-Jin Yeom, Jae-Hee Moon, Seung-Goo Lee   +6 more
semanticscholar   +1 more source

Key Trends and Insights in Smart Polymeric Skin Wearable Patches

Advanced Engineering Materials, EarlyView.
Intelligent polymers, which respond to various physical and biological stimuli, are explored for the development of skin wearable patches in biomedical applications. Smart polymers, also known as intelligent or stimuli‐responsive polymers, play a crucial role in the development of advanced wearable patches due to their versatility and softness.
Sergio J. Peñas‐Núñez, Rajat Rai, Miryam Criado‐Gonzalez   +2 more
wiley   +1 more source

Serum alkaline phosphatase predicts survival outcomes in patients with skeletal metastatic nasopharyngeal carcinoma

Clinics, 2015
OBJECTIVE: Bone metastasis is frequently associated with nasopharyngeal carcinoma. The diagnosis and follow-up of bone metastatic patients usually relies on skeletal X-ray and bone scintigraphy, which are time-consuming and costly.
Ying Jin, Mei-Qin Yuan, Jun-Qing Chen, Yi-Ping Zhang   +3 more
doaj   +1 more source

Membrane Topology of the Lactococcal Bacteriocin ATP-binding Cassette Transporter Protein LcnC. Involvement of LcnC in Lactococcin A Maturation [PDF]

, 1999
Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors with N-terminal leader peptides different from those present in preproteins exported by the general sec-dependent (type II) secretion pathway. These bacteriocins utilize
Axelsson, Bardwell, Birnboim, Boyd, Calamia, Casadaban, Chopin, Christian M. Franke, Danielsen, Dassa, Diep, Dinh, Dower, Ehrmann, Eisenberg, Fath, Franke, Gasson, Gerard Venema, Gilmore, Higgins, Holo, Hwang, Håvarstein, Jan Kok, Jan Tiemersma, Kast, Klein, Kok, Kuipers, Kyhse-Anderson, Kyte, Laemmli, Loo, Manoil, Millan, Miller, Newton, Pearce, Prinz, Quadri, Rao, Rince, Rottlander, Sambrook, Schägger, Simon, Sipos, Stoddard, Tagg, Terzaghi, Van Belkum, Van de Guchte, Venema, Venema, Venema, Vieira, Von Heijne, Wu, Yanisch-Perron, Zhang   +60 more
core   +1 more source

Magnetically Guided Mechanoactive Mineralization Scaffolds for Enhanced Bone Regeneration

Advanced Functional Materials, EarlyView.
A 3D‐printed ‘rebar‐concrete’ inspired scaffold (PGS‐P@MGel) synergizes spontaneous biomineralization with magneto‐mechanical stimulation through PDA@Fe3O4‐embedded hydrogel. This dual biointerface activates Piezo1/β‐catenin/YAP mechanotransduction axis, enhancing BMSCs osteogenesis and angiogenesis simultaneously.
Xuran Guo, Zaijin Tao, Zhenzhen Dai, Yinghua Gao, Chengzhen Chu, Cunyi Fan, Shen Liu, Xin Ma, Fangchun Jin, Zhengwei You, Jia Jiang   +10 more
wiley   +1 more source

Salivary inflammatory biomarkers during initial orthodontic tooth movement [PDF]

, 2016
BACKGROUND: Orthodontic tooth movement is a complex process involving a number of inflammatory and anabolic/catabolic pathways. Further, successful treatment depends on proper timing of orthodontic measures with regard to patient’s growth spurt ...
Serrenho, Ana
core   +1 more source

Dynamics of Bone Trap-5b Level in Patients with Bone Metastases of Renal Cell Cancer at Combined Treatment [PDF]

, 2017
The objective of this study was to determine the sensitivity of tartrate-resistant acid phosphatase (Bone TRAP-5b) for early detection of bone metastases (BM) and to investigate the efficacy of bisphosphonates (BF) (zolendronic acid-ZA) in prevention of ...
Boichuk, S. (Serhiy), Diedkov, A. (Anatoliy), Kostiuk, V. (Viktor), Ostafiychuk, V. (Vasyliy)   +3 more
core   +2 more sources

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Europium-based core-shell materials for fluorescence and colorimetric dual-mode sensing of alkaline phosphatase activity

Talanta Open
Abnormal alkaline phosphatase levels have been associated with several diseases, including tumor growth, diabetes, liver dysfunction and so on. Generally, the occurrence and prognosis of these diseases can be reflected by the serum alkaline phosphatase ...
Chen-Xi Zhao, Xiao-Xia Li, Yang Shu
doaj   +1 more source