Results 61 to 70 of about 1,115,297 (399)

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Serum alkaline phosphatase predicts survival outcomes in patients with skeletal metastatic nasopharyngeal carcinoma

Clinics, 2015
OBJECTIVE: Bone metastasis is frequently associated with nasopharyngeal carcinoma. The diagnosis and follow-up of bone metastatic patients usually relies on skeletal X-ray and bone scintigraphy, which are time-consuming and costly.
Ying Jin, Mei-Qin Yuan, Jun-Qing Chen, Yi-Ping Zhang   +3 more
doaj   +1 more source

A novel psychrophilic alkaline phosphatase from the metagenome of tidal flat sediments

BMC Biotechnology, 2015
BackgroundAlkaline phosphatase (AP) catalyzes the hydrolytic cleavage of phosphate monoesters under alkaline conditions and plays important roles in microbial ecology and molecular biology applications.
Dae-Hee Lee, Su-lim Choi, Eugene Rha, Soo-Jin Kim, Soo-Jin Yeom, Jae-Hee Moon, Seung-Goo Lee   +6 more
semanticscholar   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Salivary inflammatory biomarkers during initial orthodontic tooth movement [PDF]

, 2016
BACKGROUND: Orthodontic tooth movement is a complex process involving a number of inflammatory and anabolic/catabolic pathways. Further, successful treatment depends on proper timing of orthodontic measures with regard to patient’s growth spurt ...
Serrenho, Ana
core   +1 more source

Soil enzyme activities in the rhizosphere of field-grown sugar beet inoculated with the biocontrol agent Pseudomonas fluorescens F113 [PDF]

, 1998
The original publication is available at www.springerlink.com . Copyright Springer DOI : 10.1007/s003740050397Pseudomonas fluorescens F113, which produces the antimicrobial compound 2,4-diacetylphloroglucinol is a prospective biocontrol agent.
Lynch, J.M., Moenne-Loccoz, Y., Naseby, D.C., O'Gara, F., Powell, J.   +4 more
core   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Europium-based core-shell materials for fluorescence and colorimetric dual-mode sensing of alkaline phosphatase activity

Talanta Open
Abnormal alkaline phosphatase levels have been associated with several diseases, including tumor growth, diabetes, liver dysfunction and so on. Generally, the occurrence and prognosis of these diseases can be reflected by the serum alkaline phosphatase ...
Chen-Xi Zhao, Xiao-Xia Li, Yang Shu
doaj   +1 more source

Beryllium and Alkaline Phosphatase [PDF]

Nature, 1950
RECENTLY, two papers1,2 have appeared in which it has been shown that beryllium inhibits alkaline phosphatase by competition with magnesium. However, as inhibitions of more than 60 per cent were rarely attained, the results are of qualitative interest only.
openaire   +3 more sources

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source