Results 141 to 150 of about 225,386 (346)

Clade III Synthases Add Cyclic And Linear Terpenoids To The Psilocybe Metabolome

open access: yesChemBioChem, Accepted Article.
Psilocybe “magic mushrooms” are best known for their indolethylamine psilocybin, yet they encode enzymes for a much more diverse arsenal of small and potentially bioactive molecules. Here, we report on four Psilocybe cubensis clade III sesquiterpene synthases, CubB‐CubE, whose genes are differently expressed in fruiting bodies compared to vegetative ...
Nick Zschoche   +7 more
wiley   +1 more source

An Indole Dearomatization Strategy for the Synthesis of Pseudo‐Natural Products

open access: yesChemBioChem, EarlyView.
An indole‐dearomatization/reduction strategy is developed to expand a collection of indole‐containing pseudo‐NPs. This approach enhances the three‐dimensionality of the original compound classes through hybridization‐changing conversions leading to topologically distinct novel structures.
Joseph G. F. Hoock   +13 more
wiley   +1 more source

Biosynthesis of Ephedrine is Initiated by Pyridoxal Phosphate‐Dependent Formation of Cathinone

open access: yesChemBioChem, Accepted Article.
Ephedra alkaloids possess some of the most basic structures of alkaloids. Despite their importance for human use and their commercial relevance, the biosynthesis of ephedra alkaloids has remained enigmatic. The predominant biosynthetic pathway in the literature proposes a thiamine‐dependent caboligation followed by a transaminase, although no candidate
Karina Witte   +4 more
wiley   +1 more source

Benzylisoquinoline Biosynthesis by Cultivated Plant Cells and Isolated Enzymes [PDF]

open access: yes, 1985
Amann, Manfred   +4 more
core   +1 more source

Insights into the Mechanism of a Vanadium Bromoperoxidase from the Marine Macro‐Algae Corallina pilulifera for Biocatalytic Halogenation

open access: yesChemCatChem, EarlyView.
A study of crystallographic complexes obtained from vanadium haloperoxidase enzymes can determine key amino acids, leucine, and phenylalanine, that change their structural orientation to allow either chloride or bromide to bind to the enzymes active site, thereby determining halide specificity.
Daniel E. Mitchell   +3 more
wiley   +1 more source

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