Results 201 to 210 of about 294,987 (360)

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review

open access: yesMedicine Bulletin, EarlyView.
ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng   +8 more
wiley   +1 more source

A Lupin Alkaloid, (-)-Tenuamine (Norlusitanine), from Maackia tenuifolia

open access: diamond, 1999
Shigeru Ohmiya   +4 more
openalex   +1 more source

Residual Chemical Shift Anisotropies in the Structure Determination of Small Molecules

open access: yesMagnetic Resonance in Chemistry, EarlyView.
Plasma neutrophil elastase(ELANE) was markedly elevated in patients with alcohol use disorder, indicating a dysregulated protease‐antiprotease inflammatory balance characterised by decreased SERPINA3. ELANE showed excellent diagnostic specificity(AUC = 0.8683), supporting its potential utility as a neuroinflammatory biomarker for AUD.
Nilamoni Nath   +3 more
wiley   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

open access: yesChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda   +7 more
wiley   +1 more source

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