Results 41 to 50 of about 294,987 (360)

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Optimized genotyping method for identification of bacterial contaminants in pharmaceutical industry

Acta Pharmaceutica, 2016
Microbiological control is of crucial importance in the pharmaceutical industry regarding the possible bacterial contamination of the environment, water, raw materials and finished products. Molecular identification of bacterial contaminants based on DNA
Stamatoski Borche, Ilievska Miroslava, Babunovska Hristina, Sekulovski Nikola, Panov Sasho   +4 more
doaj   +1 more source

7‑hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects [PDF]

, 2019
Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction.
Ansonoff, Michael, Gassaway, Madalee M., Grinnell, Steven G., Javitch, Jonathan A., Kruegel, Andrew C., Langreck, Cory, Le Rouzic, Valerie, Majumdar, Susruta, Pasternak, Gavril W., Pekarskaya, Elizabeth A., Pintar, John E., Sames, Dalibor, Uprety, Rajendra   +12 more
core   +3 more sources

Microneedle‐Based Biofertilizer Delivery Improves Plant Growth Through Microbiome Engineering

Advanced Functional Materials, EarlyView.
This figure shows how microneedles are used to deliver biofertilizers to enhance plant growth through microbial migration, metabolic reprogramming, and changes in plant endogenous microbiome. Abstract This study presents a microneedle‐based system for the delivery of rhizospheric biofertilizers into plant tissues to enhance growth.
Zhicheng Le, Sevugan Mayalagu, Cheng‐Yen Chen, Raktim Bhattacharya, Abhishek Gupta, Jingyuan Li, Zhi Wei Norman Teo, Yufeng Shou, Arya Gopinath MP, Danni Zhong, Tedrick Thomas Salim Lew, Hao Yu, Naweed I. Naqvi, Sanjay Swarup, Andy Tay   +14 more
wiley   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Development and validation of an in vitro release test and use of Strat-M synthetic membrane as a predictor for the in vitro permeation test of topical gel formulations [PDF]

Makedonsko Farmacevtski Bilten
The purpose of this research was to use the vertical diffusion cell method to produce an appropriate in vitro release test for topical gel formulations.
Marija Grozdanoska Kostadinovska, Sacha Manuel, Nena Velevska, Packa Antovska, Jelena Lazova, Jasmina Tonic Ribarska, Rumenka Petkovska, Suzana Trajkovic Jolevska   +7 more
doaj   +1 more source

Antihypertensive Activity of the Alkaloid Aspidocarpine in Normotensive Wistar Rats

Molecules, 2022
The alkaloid Aspidocarpine was isolated from the bark of Aspidosperma desmanthum. Its structure was elucidated by the spectral data of 1H and 13C-NMR (1D and 2D) and high-resolution mass spectrometry (HRESIMS).
Noemi Oliveira Monteiro, Theresa de Moura Monteiro, Thalya Soares R. Nogueira, Jacqueline Rodrigues Cesar, Lara Pessanha S. Nascimento, Karoline Azerêdo Campelo, Graziela Rangel Silveira, Fernanda Antunes, Daniela Barros de Oliveira, Almir Ribeiro de Carvalho Junior, Raimundo Braz-Filho, Ivo José Curcino Vieira   +11 more
doaj   +1 more source

Rupestonic Acid of Artemisia Rupestris L. Extract Treats Pulmonary Fibrosis in COPD by Targeting TGF‐β1

Advanced Science, EarlyView.
RA of EEAR inhibits TGF‐β1 ubiquitination and changes conformation by target binding TGF‐β1, regulating TGF‐β1/Smad2/3 signaling pathway. Thus it down‐regulated downstream protein expression, inhibited EMT and collagen deposition of ECM, in order to EEAR preventing PF in COPD.
Lingfeng Peng, Lulu Zhang, Yimeng Fan, Sijuan Huang, Qingyu Zhao, Chao Han, Zhihui Hao   +6 more
wiley   +1 more source

Molecular Cages as Probes in Indicator Displacement Assays: The Case of Scopolamine Detection

Angewandte Chemie, EarlyView.
In this research, we show the concept of molecular cages as probes in indicator displacement assays, focusing on scopolamine detection, a drug often used in drug‐facilitated sexual assaults. Drug sensing occurs via the drug‐induced transformation of non‐emissive [Fluorescein2⊂Cage] complex into [Scopolamine⊂Catenane] and highly emissive free ...
Giovanni Montà‐González, Eva Garrido, Estela Climent, Cristian Vicent, Ramón Martínez‐Máñez, Vicente Martí‐Centelles   +5 more
wiley   +2 more sources

Intrinsic vs. Extrinsic Motivation in Onboarding: A Comparative Analysis in the Macedonian Pharmaceutical Industry

Journal of Human Resource Management
Purpose - The current research explores the relationship between the onboarding process and employee motivation within the pharmaceutical workforce in North Macedonia.
Tane MURGOSKI
doaj   +1 more source