Results 51 to 60 of about 390,408 (384)

Development and validation of an in vitro release test and use of Strat-M synthetic membrane as a predictor for the in vitro permeation test of topical gel formulations [PDF]

Makedonsko Farmacevtski Bilten
The purpose of this research was to use the vertical diffusion cell method to produce an appropriate in vitro release test for topical gel formulations.
Marija Grozdanoska Kostadinovska, Sacha Manuel, Nena Velevska, Packa Antovska, Jelena Lazova, Jasmina Tonic Ribarska, Rumenka Petkovska, Suzana Trajkovic Jolevska   +7 more
doaj   +1 more source

A Pharmacological Comparison of Two Isomeric Nicotinic Receptor Agonists: The Marine Toxin Isoanatabine and the Tobacco Alkaloid Anatabine

Marine Drugs, 2020
Many organisms possess “secondary” compounds to avoid consumption or to immobilize prey. While the most abundant or active compounds are initially investigated, more extensive analyses reveal other “minor” compounds with ...
Hong Xing, Sunil Keshwah, Anne Rouchaud, William R. Kem   +3 more
doaj   +1 more source

7‑hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects [PDF]

, 2019
Mitragynina speciosa, more commonly known as kratom, is a plant native to Southeast Asia, the leaves of which have been used traditionally as a stimulant, analgesic, and treatment for opioid addiction.
Ansonoff, Michael, Gassaway, Madalee M., Grinnell, Steven G., Javitch, Jonathan A., Kruegel, Andrew C., Langreck, Cory, Le Rouzic, Valerie, Majumdar, Susruta, Pasternak, Gavril W., Pekarskaya, Elizabeth A., Pintar, John E., Sames, Dalibor, Uprety, Rajendra   +12 more
core   +3 more sources

Advanced Oral Delivery Systems for Nutraceuticals

Advanced Healthcare Materials, EarlyView.
Emerging delivery technologies are explored to overcome barriers to oral nutraceutical absorption. Traditional carriers are compared with novel platforms including biodegradable polymers, MOFs, MPNs, and 3D printing. These systems enhance bioavailability, control release, and enable personalized nutrition.
Xin Yang, Linzixuan Zhang, Zhiling Zheng, Robert Langer, Ana Jaklenec   +4 more
wiley   +1 more source

Comparison of different extraction solvents for assay of the polyphenol content in the peel and pulp of 21 apple cultivars from Macedonia

Macedonian Journal of Chemistry and Chemical Engineering, 2016
Apples (Malus domestica Borkh.) contain a large array of phenolic compounds belonging to flavonoids and non-flavonoids. This study systematically evaluates the polyphenolic content of 21 apple cultivars from the Republic of Macedonia, both commercial and
Ana Petkovska, Viktor Gjamovski, Marina Stefova   +2 more
doaj   +1 more source

Catalytic asymmetric synthesis of the alkaloid (+)-myrtine [PDF]

, 2008
A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation–substitution sequence; an efficient
Adriaan J. Minnaard, Albrow, Alexakis, Alexakis, Anderson, Bach, Back, Beak, Beak, Beak, Beak, Beak, Beak, Beak, Ben L. Feringa, Bennett, Bennett, Berkheij, Bertini Gross, Brooks, Comins, Comins, Comins, Comins, Comins, Comins, Comins, Curtin, d'Augustin, Davis, Dieter, Dieter, Dieter, Dieter, Dieter, Eilitz, Frankel, Fraser, Gallagher, Garcia-Ruiz, Gardette, Gelas-Mialhe, Hoffmann, Houk, Kerrick, King, Leclercq, Liang, Maria Gabriella Pizzuti, Pilli, Pilli, Pineschi, Pàmies, Remuson, Slosse, Slosse, Still, Tawara, Vuagnoux-d'Augustin, Vuagnoux-d'Augustin, Watson, Whisler, Šebesta   +62 more
core   +1 more source

Asymmetric Synthesis of Highly Substituted Spiro[2H‐pyrrole‐2,3‐Succinimide] Derivatives by Copper‐Catalyzed Post‐Ugi Reactions

Advanced Synthesis &Catalysis, EarlyView.
Abstract Herein we present a novel one‐pot methodology for the synthesis of enantioenriched 2H‐pyrrolespirosuccinimides by copper‐catalyzed reactions on Ugi adducts derived from enantiopure α‐alkylbenzyl amines through a chirality transfer process. We have proposed a mechanism, supported by density functional theory (DFT) calculations, where a hydrogen
Javier Gómez‐Ayuso, Israel Carreira‐Barral, Roberto Quesada, María García‐Valverde   +3 more
wiley   +1 more source

Synthesis of Quinolin-2-one Alkaloid Derivatives and Their Inhibitory Activities against HIV-1 Reverse Transcriptase

Molecules, 2011
Based on an established common pharmacophore of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNTTIs), a series of quinolin-2-one derivatives were synthesized and assayed for their in vitro activities against HIV-1 reverse transcriptase (RT) for
Pi Cheng, Qiong Gu, Wei Liu, Jian-Feng Zou, Yang-Yong Ou, Zhong-Yong Luo, Jian-Guo Zeng   +6 more
doaj   +1 more source

Influence of Postharvest Drying Temperatures on Alkaloid Levels in Goldenseal (Hydrastis canadensis L.)

HortScience, 2021
Goldenseal (Hydrastis canadensis L.) is a medicinal forest herb native to Appalachia. Its roots and rhizomes are used as an antimicrobial and for the treatment of intestinal ailments.
Grady H. Zuiderveen, Eric P. Burkhart, Joshua D. Lambert   +2 more
doaj   +1 more source

Modern Strategies in Wound Healing: The Rise of Bacterial Cellulose Dressings

Advanced Therapeutics, EarlyView.
Bacterial cellulose (BC)‐based wound dressings combine high water retention, biocompatibility, and mechanical strength to support wound healing. This review highlights advanced functionalization strategies and fabrication techniques that enhance BC's therapeutic performance, establishing it as a promising material for next‐generation wound care ...
Elif Naz Gürsoy, Kubra Sener, M. Burcu Külahci, K. Barbaros Balabanli, Şule Coşkun Cevher   +4 more
wiley   +1 more source