Results 71 to 80 of about 390,408 (384)

JA‐Mediated Regulation of Amino Acid Homeostasis Adjusts Metabolic Flux and Enhances Spider Mite Tolerance via the SlJAZ8‐SlWRKY57‐SlAVT6s Module in Tomato

Advanced Science, EarlyView.
This study elucidates a novel SlJAZ8‐SlWRKY57‐SlAVT6A/SlAVT6B module that effectively channels metabolic flux from primary to secondary metabolism, impacting plant growth, development, and resistance. Two novel vacuolar amino acid exporters, SlAVT6A and SlAVT6B, fine‐tunes trichomes, terpenes, and gibberellins, bolstering spider mite resistance.
Yingchen Hao, Xiaolong Wang, Langchen Guo, Lijun Xiang, Enxi Luo, Peng Cao, Penghui Liu, Yue Zhong, Chun Li, Jun Lai, Jun Yang, Shouchuang Wang   +11 more
wiley   +1 more source

Shaping of a Reactive Manganese Catalyst Enables Access to Polyfunctionalized Cyclohexanes via Enantioselective C(sp3)─H Bond Oxidation of 1,3‐meso Diethers

Angewandte Chemie, EarlyView.
Structural shaping of a highly reactive chiral Mn‐oxo species translates into exceptionally enantioselective C─H oxidation catalyst of cyclohexyl 1,3‐meso diethers (up to >99% ee) leading to polyfunctionalized cyclohexanes. Abstract Chiral polyoxygenated cyclohexanes are valuable constituents of biologically relevant products.
Andrea Palone, Arnau Call, Aleria Garcia‐Roca, Josep M. Luis, Matthew S. Sigman, Massimo Bietti, Cristina Nevado, Miquel Costas   +7 more
wiley   +2 more sources

An Acetylenic Alkaloid from the Calcareous Sponge Leucetta sp.

Marine Drugs, 2011
A new acetylenic alkaloid was isolated from the sponge Leucetta sp. The structure was established by analyzing spectroscopic data. The alkaloid showed cytotoxicity IC50 2.5 mg/mL against NBT-T2 cells.
Nicole J. de Voogd, Idam Hermawan, Junichi Tanaka   +2 more
doaj   +1 more source

Hasil Similirarty Pengaruh metode penyarian terhadap kadar alkaloid total daun jembirit (Tabernaemontana sphaerocarpa. BL) dengan metode spektrofotometri visibel [PDF]

, 2017
Salah satu tanaman yang mengandung alkaloid adalah tanaman jembirit (Tabernaemontana sphaerocarpa BL). Getah dan daun dari tanaman ini telah digunakan untuk mengobati penyakit kulit dan keseleo.
Al Abror, Muhti, Rozak, Miftahul, Salamah, Nina   +2 more
core   +4 more sources

Total Synthesis of the Akuammiline Alkaloid Picrinine

Journal of the American Chemical Society, 2014
We report the first total synthesis of the complex akuammiline alkaloid picrinine, which was first isolated nearly five decades ago. Our synthetic approach features a concise assembly of the [3.3.1]-azabicyclic core, a key Fischer indolization reaction ...
Joel M. Smith, Jesus Moreno, Ben W. Boal, N. Garg   +3 more
semanticscholar   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

Total Synthesis of Isodaphlongamine H by Iridium‐Catalyzed Reductive [3 + 2] Cycloaddition of N‐Hydroxylactam

Angewandte Chemie, EarlyView.
The total synthesis of isodaphlongamine H was accomplished by a lactam strategy. This strategy started with alkylation and N‐oxidation of a readily available chiral lactam. For the key functionalization of the amide carbonyl, an iridium‐catalyzed reductive [3 + 2] cycloaddition of the N‐hydroxylactam afforded the tricyclic isoxazolidine, which was ...
Sora Iwamoto, Reki Nakano, Keiji Sasaki, Shoichiro Kobayashi, Yuki Taira, Koya Takei, Reiji Kawakita, Ayako Tokuyama, Haruto Nakamura, Manato Tomoike, Ryota Kawahara, Akari Murase, Siro Simizu, Noritaka Chida, Toshitaka Okamura, Takaaki Sato   +15 more
wiley   +2 more sources

A Novel nor@DHB Matrix for Direct Microbial Analysis in Lung Cancer Tissues

Advanced Science, EarlyView.
Integrated matrix‐assisted laser desorption/ionization mass spectrometry workflow quantifies intratumoral microbes in lung cancer through lipopolysaccharide/lipid A extraction from biopsies. The novel ionic matrix called norharmane conjugated to 2,5‐dihydroxybenzoic acid enhances lipid A ionization, enabling direct detection of bacterial genera ...
Liang Shan, Xin Xu, Lin Huang, Dan Li, Yiran Deng, Xiangfei Xue, Susu Guo, Yiman Huang, Xiao Zhang, Yongchun Yu, Lifang Ma, Kun Qian, Jiayi Wang   +12 more
wiley   +1 more source

Iridium‐Catalyzed Enantioselective Intramolecular Hydroarylation of Allenes: Formal Synthesis of (+)‐Rhazinilam

Angewandte Chemie, EarlyView.
A highly enantioselective iridium‐catalyzed hydroarylation of allene‐tethered pyrroles and indoles that provides access to relevant heterocyclic systems bearing vinyl‐substituted 3ry or 4ry stereocenters is reported. Its synthetic potential was exemplified with a very short, highly enantioselective formal synthesis of (+)‐Rhazinilam, whereas DFT ...
Andrés Arribas, Alejandro Rey, Martín Calvelo, José L. Mascareñas, Fernando López   +4 more
wiley   +2 more sources

Discovery and Evaluation of Thiazinoquinones as Anti-Protozoal Agents

Marine Drugs, 2013
Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC50 3.1 μM) and Plasmodium falciparum (K1 dual drug resistant ...
Marcel Kaiser, Brent R. Copp, A. Norrie Pearce, Shen H. Tan, Cary F. C. Lam   +4 more
doaj   +1 more source