Results 21 to 30 of about 229,471 (214)

Biosynthesis of medicinal tropane alkaloids in yeast

Nature, 2020
Tropane alkaloids from nightshade plants are neurotransmitter inhibitors that are used for treating neuromuscular disorders and are classified as essential medicines by the World Health Organization 1 , 2 .
P. Srinivasan, C. Smolke
semanticscholar   +1 more source

Beneficial Effect of Alkaloids From Sophora alopecuroides L. on CUMS-Induced Depression Model Mice via Modulating Gut Microbiota

Frontiers in Cellular and Infection Microbiology, 2021
It was recently shown that the gut microbiota of both depression patients and depression model animals is significantly altered, suggesting that gut microbes are closely related to depression. Here, we investigated the effects of Sophora alopecuroides L.-
Ming Zhang, Aoqiang Li, Qifang Yang, Jingyi Li, Lihua Wang, Xiuxian Liu, Yanxin Huang, Lei Liu   +7 more
doaj   +1 more source

Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CLpro): an in silico screening of alkaloids and terpenoids from African medicinal plants

Journal of Biomolecular Structure and Dynamics, 2020
The novel coronavirus disease 2019 (COVID-19) caused by SARS-COV-2 has raised myriad of global concerns. There is currently no FDA approved antiviral strategy to alleviate the disease burden.
G. Gyebi, O. Ogunro, A. P. Adegunloye, Oludare Michael Ogunyemi, S. Afolabi   +4 more
semanticscholar   +1 more source

Alkaloids in Marine Algae

Marine Drugs, 2010
This paper presents the alkaloids found in green, brown and red marine algae. Algal chemistry has interested many researchers in order to develop new drugs, as algae include compounds with functional groups which are characteristic from this particular ...
Ekrem Sezik, Aline Percot, Kasım Cemal Güven   +2 more
doaj   +1 more source

Analysis of glutathione-S-transferases from larvae of Galleria mellonella (Lepidoptera, Pyralidae) with potential alkaloid detoxification function

Frontiers in Physiology, 2022
The greater wax moth, Galleria mellonella, is a global pest for beehives, doing damage in the larval stage. Although a significant number of studies have reported on larvae and adults, to date no effective pest control has been implemented. In this study,
Herbert Venthur, Herbert Venthur, Paula Lizana, Loreto Manosalva, Valentina Rojas, Ricardo Godoy, Adonis Rocha, Iván Aguilera, Rubén Palma-Millanao, Victor Fajardo, Andrés Quiroz, Andrés Quiroz, Ana Mutis, Ana Mutis   +13 more
doaj   +1 more source

Effect of Ultrasound Application on Protein Yield and Fate of Alkaloids during Lupin Alkaline Extraction Process

Biomolecules, 2020
The objective of this work is to elucidate the fate of quinolizidine alkaloids (QA) during the lupin protein extraction process assisted with ultrasound and the evaluation of the nutritional and functional properties of the protein fraction.
Luis Alberto Aguilar-Acosta, Sergio O. Serna-Saldivar, José Rodríguez-Rodríguez, Anayansi Escalante-Aburto, Cristina Chuck-Hernández   +4 more
doaj   +1 more source

A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids

Nature Communications, 2020
The tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive natural products and semi-synthetic analogs. Plants manufacture more than 3,000 THIQ alkaloids, including the opioids morphine and codeine.
M. Pyne, K. Kevvai, Parbir S. Grewal, Lauren Narcross, Brian Choi, L. Bourgeois, J. Dueber, V. Martin   +7 more
semanticscholar   +1 more source

Effect of processing on the alkaloids in Aconitum tubers by HPLC-TOF/MS

Journal of Pharmaceutical Analysis, 2017
According to the Chinese Pharmacopoeia 2015, only processed Aconitum tubers can be clinically applied, and the effect of processing is unclear. This research aimed to explore the effect of processing on cardiac efficacy of alkaloids in Aconitum tubers ...
Min Liu, Yan Cao, Diya Lv, Wen Zhang, Zhenyu Zhu, Hai Zhang, Yifeng Chai   +6 more
doaj   +1 more source

A spotlight on alkaloid nanoformulations for the treatment of lung cancer

Frontiers in Oncology, 2022
Numerous naturally available phytochemicals have potential anti-cancer activities due to their vast structural diversity. Alkaloids have been extensively used in cancer treatment, especially lung cancers, among the plant-based compounds.
Sindhoor S. M., N. Raghavendra Naveen, GSN Koteswara Rao, Gopika Gopan, Hitesh Chopra, Moon Nyeo Park, Mohammed Merae Alshahrani, Jobin Jose, Talha Bin Emran, Talha Bin Emran, Bonglee Kim   +10 more
doaj   +1 more source

Quality Assessment of Kumu Injection, a Traditional Chinese Medicine Preparation, Using HPLC Combined with Chemometric Methods and Qualitative and Quantitative Analysis of Multiple Alkaloids by Single Marker

Molecules, 2018
Kumu injection (KMI) is a common-used traditional Chinese medicine (TCM) preparation made from Picrasma quassioides (D. Don) Benn. rich in alkaloids.
Ning Wang, Zhi-Yong Li, Xiao-Li Zheng, Qiao Li, Xin Yang, Hui Xu   +5 more
doaj   +1 more source