Results 31 to 40 of about 157,429 (315)

Cardiotropic medicinal products of plant origin. Prospects for use in modern clinical practice

Research Results in Pharmacology
Introduction: The aim of the research was to study the current state of use and improvement of the prospects for the using cardiological medicinal products obtained on the basis of medicinal plant raw materials.
Nadezhda V. Nesterova, Natalia D. Bunyatyan, Irina A. Samylina, Vladimir A. Evteev   +3 more
doaj   +1 more source

Foliar nitrogen supply enhances the recovery of photosynthetic performance of cold-stressed coffee (Coffea arabica L.) seedlings

Photosynthetica, 2020
Cold-stressed leaves possess an elevated risk of photodamage due to an inefficient photosynthetic apparatus during winter conditions. Recovery of cold-stressed coffee seedlings treated with different concentrations of nitrogen applied as foliar urea ...
R. ACIDRI, Y. SAWAI, Y. SUGIMOTO, D. SASAGAWA, T. MASUNAGA, S. YAMAMOTO, E. NISHIHARA   +6 more
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

NMR Metabolomic Profiling of Differentiated SH-SY5Y Neuronal Cells: Amyloid-β Toxicity and Protective Effects of Galantamine and Lycorine

Cells
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by metabolic dysregulation, oxidative stress, amyloid-β (Aβ) aggregation, metal dyshomeostasis, and mitochondrial dysfunction.
Arian Kola, Filippo Costanti, Jordan Kahfi, Abdul-Hamid Emwas, Mariusz Jaremko, Daniela Valensin   +5 more
doaj   +1 more source

Variations of Alkaloid Accumulation and Gene Transcription in Nicotiana tabacum

Biomolecules, 2018
To increase the understanding of alkaloid biosynthesis in Nicotiana tabacum during whole plant growth periods, variations of the contents of alkaloids and the transcription of key biosynthetic genes in fresh leaves were investigated in three varieties at
Bo Sun, Yu-Xiao Tian, Fen Zhang, Qing Chen, Yong Zhang, Ya Luo, Xiao-Rong Wang, Fu-Cheng Lin, Jun Yang, Hao-Ru Tang   +9 more
doaj   +1 more source

Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective

Molecules, 2021
Plant-based indole alkaloids are very rich in pharmacological activities, and the indole nucleus is considered to contribute greatly to these activities.
Faisal Omar, Abu Montakim Tareq, Ali M. Alqahtani, Kuldeep Dhama, Mohammed Abu Sayeed, Talha Bin Emran, Jesus Simal-Gandara   +6 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Anisotropic NMR as a Crucial Tool for Differentiation of Epimers With High Conformational Flexibility

Angewandte Chemie, EarlyView.
Epimer discrimination remains challenging due to subtle NMR differences. Here, we propose a methodology based on 13C‐RCSA and RDC anisotropic parameters, enabling the assignment of two flexible tetraprenyltoluquinol epimers (1a and 1b) with remote stereoclusters.
Juan Carlos C. Fuentes‐Monteverde, Abel M. Forero, Nilamoni Nath, Antonio Hernández Daranas, Carlos Jiménez, Jaime Rodríguez, Christian Griesinger   +6 more
wiley   +2 more sources

Pyrrolizidine alkaloids

Nat. Prod. Rep., 2014
This review focuses on the isolation and synthesis of natural products containing a 1-azabicyclo[3.3.0]octane core (July 2001 to December 2012).
Robertson, J, Stevens, K
openaire   +3 more sources

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source