Results 21 to 30 of about 103,487 (263)

Evaluating the therapeutic role of selected active compounds in Plumula Nelumbinis on pulmonary hypertension via network pharmacology and experimental analysis

Frontiers in Pharmacology, 2022
Excessive proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) are critical factors leading to vascular remodeling in pulmonary hypertension (PH).
Xinghua Xiao, Xinghua Xiao, Xinghua Xiao, Fangmei Luo, Minyi Fu, Minyi Fu, Minyi Fu, Yueping Jiang, Yueping Jiang, Yueping Jiang, Shao Liu, Shao Liu, Shao Liu, Bin Liu, Bin Liu, Bin Liu   +15 more
doaj   +1 more source

The Promotion of Festuca sinensis under Heavy Metal Treatment Mediated by Epichloë Endophyte

Agronomy, 2021
To more clearly clarify the relationship between the Epichloë endophyte and its host, F. sinensis, the effects of Epichloë endophyte on F. sinensis performance under heavy metal treatment was investigated. The growth performance and physiology variations
Meining Wang, Pei Tian, Min Gao, Miaomiao Li   +3 more
doaj   +1 more source

Exploring the Pharmacological Potential of Lithospermum officinale L.: A Review of Phytochemicals and Ethnomedicinal Uses

Molecules
Exploring phytochemicals from ethnomedicinal plants for pharmacological applications is a promising research area. By studying ethnomedicine, researchers can identify plants used for centuries to treat ailments and investigate their phytochemicals ...
Gulzhanat Barkizatova, Aknur Turgumbayeva, Kairat Zhakipbekov, Kuralay Bekesheva, Zhalgaskali Arystanov, Tanagul Arystanova, Farida Kayupova, Klara Zhumalina, Zhanat Toxanbayeva, Aigul Ibragimova, Olga Blinova, Gulnara Utegenova, Nurzhan Iztileu, Zhanserik Shynykul   +13 more
doaj   +1 more source

The Cultivation of Chelidonium majus L. Increased the Total Alkaloid Content and Cytotoxic Activity Compared with Those of Wild-Grown Plants

Plants, 2021
The effect of cultivation practises on both the phytochemical profile and biological activity of aqueous ethanol extracts of Chelidonium majus L. was studied. Extracts were prepared from aerial parts of the same plant population collected in the wild and
Valerija Krizhanovska, Inga Sile, Arta Kronberga, Ilva Nakurte, Ieva Mezaka, Maija Dambrova, Osvalds Pugovics, Solveiga Grinberga   +7 more
doaj   +1 more source

A Comprehensive Description of the Anatomy and Histochemistry of Psychotria capillacea (Müll. Arg.) Standl. and an Investigation into Its Anti-Inflammatory Effects in Mice and Role in Scopolamine-Induced Memory Impairment

Pharmaceuticals
Species of the genus Psychotria are used in popular medicine for pain, inflammatory symptoms, and mental disorders. Psychotria capillacea (Müll. Arg.) Standl.
Anelise Samara Nazari Formagio, Wagner Vilegas, Cândida Aparecida Leite Kassuya, Valter Paes De Almeida, Jane Manfron, Elisabete Castelon Konkiewitz, Edward Benjamin Ziff, Janaine Alberto Marangoni Faoro, Jessica Maurino Dos Santos, Ana Julia Cecatto, Maria Helena Sarragiotto, Rosilda Mara Mussury   +11 more
doaj   +1 more source

Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar

Molecules, 2021
Seeds of Crotalaria cleomifolia (Fabaceae) are consumed in Madagascar in preparation of popular beverages. The investigation of extracts from the seeds of this species revealed the presence of high amounts of alkaloids from which two pyrrolizidine ...
Anjaramampionona Henintsoa Duvale Solofomalala, Clara Fredeline Rajemiarimoelisoa, Randriamampianina Lovarintsoa Judicael, Hanitra Ranjana Randrianarivo, Danielle Aurore Doll Rakoto, Victor Louis Jeannoda, Ahcène Boumendjel   +6 more
doaj   +1 more source

HOF‐Stabilized Apple EV Nanocargo in an NIR‐Responsive Hydrogel Enables On‐Demand Therapeutic Modulation for Transdermal Deep‐Joint Osteoarthritis Therapy

Advanced Healthcare Materials, EarlyView.
An NIR‐responsive transdermal hydrogel integrating apple EV nanocargo, berberine, piperine, HOFs, and graphene oxide enables localized osteoarthritis modulation. The platform supports enhanced transdermal delivery together with mild hyperthermia‐associated and redox‐related responses, leading to reduced inflammation and oxidative stress, improved ...
Yu‐Wen Tseng, Pei‐Wei Weng, Hsien‐Tsung Lu, Jiunn‐Horng Kang, Lekha Rethi, Lekshmi Rethi, Yan‐Ting Chen, Hieu Trung Nguyen, Yao‐Tung Tsai, Andrew E.‐Y. Chuang   +9 more
wiley   +1 more source

Optimization of Tabersonine Methoxylation to Increase Vindoline Precursor Synthesis in Yeast Cell Factories

Molecules, 2021
Plant specialized metabolites are widely used in the pharmaceutical industry, including the monoterpene indole alkaloids (MIAs) vinblastine and vincristine, which both display anticancer activity.
Pamela Lemos Cruz, Natalja Kulagina, Grégory Guirimand, Johan-Owen De Craene, Sébastien Besseau, Arnaud Lanoue, Audrey Oudin, Nathalie Giglioli-Guivarc’h, Nicolas Papon, Marc Clastre, Vincent Courdavault   +10 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Marine Pyrrole Alkaloids

Marine Drugs, 2021
Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal intriguing structures. They are not only widespread in terrestrial habitats but can also frequently be found as natural products in the marine environment.
Kevin Seipp, Leander Geske, Till Opatz
doaj   +1 more source