Results 71 to 80 of about 125,698 (285)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

On the analysis of long-chain alkane diols and glycerol ethers in biochemical studies

Journal of Lipid Research, 1971
The chromatographic behavior of 1,2-, 1,3-, 1,4-, and 1,12-long-chain alkane diols and 1-O-alkylglycerols and their derivatives has been compared. Thin-layer chromatography on Silica Gel G gives poor separations of the 1,2-, 1,3-, and 1,4-alkane diols, O-
M.L. Blank, Edgar A. Cress, Nelson Stephens, Fred Snyder   +3 more
doaj   +1 more source

Leaf Waxes and Hemicelluloses in Topsoils Reflect the δ2H and δ18O Isotopic Composition of Precipitation in Mongolia

Frontiers in Earth Science, 2020
Compound-specific hydrogen and oxygen isotope analyzes on leaf wax-derived n-alkanes (δ2Hn–alkane) and the hemicellulose-derived sugar arabinose (δ18Oara) are valuable, innovative tools for paleohydrological reconstructions.
Julian Struck, Marcel Bliedtner, Paul Strobel, Lucas Bittner, Lucas Bittner, Enkhtuya Bazarradnaa, Darima Andreeva, Wolfgang Zech, Bruno Glaser, Michael Zech, Roland Zech   +10 more
doaj   +1 more source

Quantifying sources of methane using light alkanes in the Los Angeles basin, California [PDF]

, 2013
Methane (CH4), carbon dioxide (CO2), carbon monoxide (CO), and C2-C5 alkanes were measured throughout the Los Angeles (L.A.) basin in May and June 2010. We use these data to show that the emission ratios of CH4/CO and CH4/CO2 in the L.A. basin are larger
Aikin, KC, Andrews, AE, Atlas, E, Blake, D, Brioude, J, Daube, BC, De Gouw, JA, Dlugokencky, E, Frost, GJ, Gentner, DR, Gilman, JB, Goldstein, AH, Harley, RA, Holloway, JS, Kofler, J, Kuster, WC, Lang, PM, Novelli, PC, Parrish, DD, Peischl, J, Ryerson, TB, Santoni, GW, Trainer, M, Wofsy, SC   +23 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Review of Classification of PCMs, with a Focus on the Search for New, Suitable PCM Candidates

Energies
With a growing number of PCMs and new, suitable PCM candidates, an overview is not only important, but also increasingly complex. Classification of PCM was thus changed significantly in the past decades.
Harald Mehling
doaj   +1 more source

General method for prediction of thermal conductivity for well-characterized hydrocarbon mixtures and fuels up to extreme conditions using entropy scaling [PDF]

, 2019
A general and efficient technique is developed to predict the thermal conductivity of well-characterized hydrocarbon mixtures, rocket propellant (RP) fuels, and jet fuels up to high temperatures and high pressures (HTHP).
Akhmedova-Azizova, Arcoumanis, Arikol, Ashutosh Gupta, Assael, Assael, Assael, Assael, Assael, Baroncini, Baroncini, Baroncini, Baroncini, Battistoni, Briggs, Burgess, Chickos, Chung, Chung, Deng, Fareleira, Fareleira, Fouad, Gharagheizi, Gharagheizi, Gharagheizi, Giannadakis, Gross, Guo, Hopp, Houman B. Rokni, Huber, Huber, Huber, Jia, Joshua D. Moore, Kashiwagi, Kesler, Lashkarbolooki, Latini, Latini, Lazzús, Liang, Lötgering-Lin, Manolis Gavaises, Mark A. McHugh, Mathias, Nagvekar, Park, Pomraning, Rajendar R. Mallepally, Ramos-Pallares, Ramos-Pallares, Rastorguev, Rodenbush, Rokni, Rokni, Rosenfeld, Roy, Sastri, Sauer, Schilling, Schmidt, Stiel, Tamouza, Teja, Teja, Thi, Tihic, Wada, Wakeham, Wu, Xu   +72 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Reactivity and fate of secondary alkane sulfonates (SAS) in marine sediments [PDF]

, 2014
This research is focused on secondary alkane sulfonates (SAS), anionic surfactants widely used in household applications that access aquatic environments mainly via sewage discharges.We studied their sorption capacity and anaerobic degradation in marine ...
Aitken, Baena-Nogueras, Bruno, Callaghan, Davidova, Di Toro, Eduardo González-Mazo, El Rayis, Field, Field, García, García, Gaudette, HERA project, José Luis Sanz, Kolpin, Köchling, Lara-Martín, Lara-Martín, Lara-Martín, Lara-Martín, Lara-Martín, Madigan, Mbadinga, Pablo A. Lara-Martín, Patricia Rojas-Ojeda, Rosa María Baena-Nogueras, Rubio, Schröeder, Swisher, Thysse, Westall, Wilkes   +32 more
core   +2 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source