Results 41 to 50 of about 31,317 (246)

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

GC-MS metabolic profiling and free radical scavenging activity of Micromeria dalmatica

Biologica Nyssana, 2016
Metabolite profile of acetone exudate and methanolic extract from aerial parts of Micromeria dalmatica Benth were analyzed by GC/MS. Palmitic and linolenic acids, hentriacontane, amyrin, quercetagetin 3,6,7-trimethyl ether, sucrose were identified ...
Nikolova, M., Aneva, I., Berkov, S.
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Compositional variances in petal cuticular wax of eight rose species and their impacts on vase life under water-loss stress

Frontiers in Plant Science
Cuticular wax is the first barrier between plants and the environment. Here, the densities of cuticular wax crystals on the petals of eight rose cultivars were determined to be sparse; the crystals were mostly granular and only a few rod-shaped crystals ...
Xuan Hao, Junheng Lv, Zixian Zhao, Yuxin Tong, Minghua Deng, Jinfen Wen   +5 more
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PETROCHEMICAL EMISSIONS PRODUCED BY THE OBJECTS OF THE AUTOMOBILE AND HIGHWAY COMPLEX [PDF]

Avtomobilʹnyj Transport (Harʹkov), 2015
As a result of experimental researches it was established that the flow of petrochemicals from the ob-jects of the automobile and highway complex that spreads over the adjoining roadside areas corre-lates with the traffic intensity at objects of the same
V. Iurchenko, O. Melnikova, L. Mykhailova, T. Fisher   +3 more
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KOtBu as a Single Electron Donor? Revisiting the Halogenation of Alkanes with CBr4 and CCl4

Molecules, 2018
The search for reactions where KOtBu and other tert-alkoxides might behave as single electron donors led us to explore their reactions with tetrahalomethanes, CX4, in the presence of adamantane.
Katie J. Emery, Allan Young, J. Norman Arokianathar, Tell Tuttle, John A. Murphy   +4 more
doaj   +1 more source

Bioremediation of Oil-Contaminated Soil of the Republic of Kazakhstan Using a New Biopreparation

Microorganisms, 2023
A new biopreparation is developed to clean soils from oil pollution in the arid climate of the Republic of Kazakhstan. The biopreparation includes bacterial strains R. qingshengii F2-1, R. qingshengii F2-2, and P. alloputida BS3701.
Tatiana Vyacheslavovna Funtikova, Lenar Imametdinovich Akhmetov, Irina Filippovna Puntus, Pavel Alexeevich Mikhailov, Nurbol Orynbasaruly Appazov, Roza Abdibekovna Narmanova, Andrey Evgenievich Filonov, Inna Petrovna Solyanikova   +7 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Metabolic engineering of Yarrowia lipolytica for enhanced microbial production of medium-chain α, ω-diols from alkanes via CRISPR-Cas9 mediated pathway optimization and P450 alkane monooxygenase overexpression

Frontiers in Bioengineering and Biotechnology
IntroductionMedium- to long-chain α, ω-diols are valuable building blocks for polyesters and polyurethanes, yet their microbial synthesis from inexpensive alkane feedstocks remains largely undeveloped.
Ye Chan Kim, Won Yoon Hwan Choi, Eun-Jung Kim, Byung‐Gee Kim, Hyungdon Yun   +4 more
doaj   +1 more source

Saturated-liquid heat capacity calculation of alkanes [PDF]

Journal of the Serbian Chemical Society, 2005
An empirical model for the calculation of the heat capacity of alkanes is recommended. This model was tested and compared to known models (Luria–Benson and Rizicka–Domalski) using 68 sets with 1155 literature experimental heat capacity data of 39 ...
JOVAN D. JOVANOVIC, DUSAN K. GROZDANIC
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