Structure and mechanism of the alkane-oxidizing enzyme AlkB
Nature Communications, 2023 Alkanes are the most energy-rich form of carbon and are widely dispersed in the environment. Their transformation by microbes represents a key step in the global carbon cycle.
Xue Guo +8 more
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The role of demethylase AlkB homologs in cancer
Frontiers in Oncology, 2023 The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qiao Li, Qiao Li, Qingsan Zhu
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Bioinformatic mapping of AlkB homology domains in viruses [PDF]
BMC Genomics, 2005 Background AlkB-like proteins are members of the 2-oxoglutarate- and Fe(II)-dependent oxygenase superfamily. In Escherichia coli the protein protects RNA and DNA against damage from methylating agents. 1-methyladenine and 3-methylcytosine are repaired by
Drabløs Finn, Bratlie Marit S
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An Overview of the Electron-Transfer Proteins That Activate Alkane Monooxygenase (AlkB)
Frontiers in Microbiology, 2022 Alkane-oxidizing enzymes play an important role in the global carbon cycle. Alkane monooxygenase (AlkB) oxidizes most of the medium-chain length alkanes in the environment. The first AlkB identified was from P.
Shoshana C. Williams +1 more
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NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli [PDF]
Nature Communications, 2019 Bacterial tRNA is modified by thiolation of nucleosides. Here the authors identify 2-methylthiocytidine in bacterial tRNA using nucleic acid isotope labeling coupled mass spectrometry.
Valentin F. Reichle +4 more
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The AlkB Family: Potential Prognostic Biomarkers and Therapeutic Targets in Glioblastoma
Frontiers in Oncology, 2022 The AlkB family of Fe (II) and α-ketoglutarate-dependent dioxygenases works by removing alkyl substituents from alkylation-damaged nucleic acid bases through oxidative dealkylation, subsequently affecting tumor progression and patient prognosis. However,
Songshan Feng +7 more
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The bioinformatics and experimental analysis of AlkB family for prognosis and immune cell infiltration in hepatocellular carcinoma [PDF]
PeerJ, 2021 Background Serving as N6-methyladenosine demethylases, the AlkB family is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the molecular profiles and clinical values of the AlkB family in HCC are not well known.
Bi Peng, Yuanliang Yan, Zhijie Xu
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A novel alkane monooxygenase (alkB) clade revealed by massive genomic survey and its dissemination association with IS elements [PDF]
PeerJ, 2022 Background Alkanes are important components of fossil energy, such as crude oil. The alkane monooxygenase encoded by alkB gene performs the initial step of alkane degradation under aerobic conditions.
Shaojing Wang +4 more
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Вавиловский журнал генетики и селекции, 2022 Alkanmonooxygenase enzymes AlkB and Cyp153 are responsible for the aerobic degradation of n-alkanes of petroleum and petroleum products. To prove the usage of n-alkanes from oil and petroleum products by hydrocarbon- oxidizing bacteria isolated from ...
T. N. Shapiro +2 more
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Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis
Frontiers in Physiology, 2022 Dentinogenesis is a key process in tooth formation and is regulated by a series of pre- and post-transcriptional regulations. N6-methyl-adenosine (m6A), which is the most prevalent internal chemical modification that can be removed by the RNA demethylase
Cheng Tian +9 more
semanticscholar +4 more sources