The role of demethylase AlkB homologs in cancer
Frontiers in Oncology, 2023 The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qiao Li, Qiao Li, Qingsan Zhu
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Bioinformatic mapping of AlkB homology domains in viruses [PDF]
BMC Genomics, 2005 Background AlkB-like proteins are members of the 2-oxoglutarate- and Fe(II)-dependent oxygenase superfamily. In Escherichia coli the protein protects RNA and DNA against damage from methylating agents. 1-methyladenine and 3-methylcytosine are repaired by
Drabløs Finn, Bratlie Marit S
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The AlkB Family: Potential Prognostic Biomarkers and Therapeutic Targets in Glioblastoma
Frontiers in Oncology, 2022 The AlkB family of Fe (II) and α-ketoglutarate-dependent dioxygenases works by removing alkyl substituents from alkylation-damaged nucleic acid bases through oxidative dealkylation, subsequently affecting tumor progression and patient prognosis. However,
Songshan Feng +7 more
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Cloning and Expression of Pseudomonas aeruginosa AlkB Gene in E. coli
Journal of Pure and Applied Microbiology, 2020 Pre identified hydrocarbons degrading bacteria were used in this study, specific primer was conducted to amplification of AlkB gene, approximately 1206bp band size of this gene for Pseudomonas aeruginosa was detected and proofed by sequence and ...
Fadhil N. Al-Kanany, Rasha M. Othman
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Current Issues in Molecular BiologyAlkylating modifications induced by either exogenous chemical agents or endogenous metabolites are some of the main types of damage to DNA, RNA, and proteins in the cell.
Anastasiia T. Davletgildeeva +1 more
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Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins [PDF]
Nucleic Acids Research, 2004 Pål Ø Falnes
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Detection of Brucella abortus by alkB and IS711 based primers
Journal of Research in Medical Sciences, 2007 <font face="TimesNewRoman,Bold" size="1"><p align="left"><strong>BACKGROUND<font face="TimesNewRoman" size="1">: </font></strong><font face="TimesNewRoman" size="2">Brucellosis is a zoonotic disease, which ...
Seyed Reza Hosseini Doust +5 more
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The Alkane 1-Monooxygenase Gene alkB of Pseudomonas sp. FF2 Is Upregulated During Colonisation of Arabidopsis thaliana Leaves. [PDF]
Environ Microbiol RepGiven that leaf cuticular waxes restrict access to nutrients and water to bacteria on leaf surfaces, we developed a bioreporter in Pseudomonas sp. FF2 to monitor the activity of the alkB promoter, involved in alkane degradation. The bioreporter revealed heterogeneous alkB expression in vitro and on Arabidopsis thaliana leaves, consistent with a bet ...
Schlechter R +4 more
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The bioinformatics and experimental analysis of AlkB family for prognosis and immune cell infiltration in hepatocellular carcinoma [PDF]
PeerJ, 2021 Background Serving as N6-methyladenosine demethylases, the AlkB family is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the molecular profiles and clinical values of the AlkB family in HCC are not well known.
Bi Peng, Yuanliang Yan, Zhijie Xu
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Expression and molecular profiles of the AlkB family in ovarian serous carcinoma
Aging, 2021 AlkB family of Fe (II) and α-ketoglutarate-dependent dioxygenases plays essential roles in development of ovarian serous carcinoma (OV). However, the molecular profiles of AlkB family in OV have not been clarified. The results indicated that the expression of ALKBH1/3/5/8 and FTO was lower in OV patients while ALKBH2/4/6/7 expression was higher.
Yuan Cai +6 more
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