Molecular Detection and Phylogenetic Analysis of the alkB Gene in Klebsiella oxytoca Strains Isolated from the Gut of Tenebrio molitor [PDF]
The Scientific World JournalThe challenge in polystyrene disposal has caused researchers to look for urgent innovative and ecofriendly solutions for plastic degradation. Some insects have been reported to use polystyrene as their sole carbon source, and this has been linked to the ...
Tsitsi Lynn Mupamhadzi +3 more
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Journal of Degraded and Mining Lands ManagementDiesel fuel pollutants contain toxic hydrocarbons dominated by aliphatic and aromatic hydrocarbons. Hydrocarbon pollutants can be degraded in an environmentally friendly manner through bioremediation using hydrocarbonoclastic bacteria, i.e., Pseudomonas ...
Pieter Jhon Joshua Daris +3 more
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Dealkylation of Macromolecules by Eukaryotic α-Ketoglutarate-Dependent Dioxygenases from the AlkB-like Family [PDF]
Current Issues in Molecular BiologyAlkylating modifications induced by either exogenous chemical agents or endogenous metabolites are some of the main types of damage to DNA, RNA, and proteins in the cell.
Anastasiia T. Davletgildeeva +1 more
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Generalization of Classification of AlkB Family Alkane Monooxygenases from Rhodococcus (sensu lato) Group Based on Phylogenetic Analysis and Genomic Context Comparison [PDF]
Int J Mol SciAlkane-oxidizing bacteria play a crucial role in the global carbon cycle. Rhodococcus species are well-known hydrocarbon degraders, distinguished by the harboring of multiple homologs of AlkB family alkane monooxygenases.
K. Petrikov +4 more
semanticscholar +3 more sources
The Selectivity and Inhibition of AlkB [PDF]
Journal of Biological Chemistry, 2003 AlkB is one of four proteins involved in the adaptive response to DNA alkylation damage in Escherichia coli and is highly conserved from bacteria to humans. Recent analyses have verified the prediction that AlkB is a member of the Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenase family of enzymes.
Welford, R +4 more
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DNA, 2023 Nucleic acid methylations are important genetic and epigenetic biomarkers. The formation and removal of these markers is related to either methylation or demethylation.
Zhiyuan Peng +5 more
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Expression and molecular profiles of the AlkB family in ovarian serous carcinoma
Aging, 2021 AlkB family of Fe (II) and α-ketoglutarate-dependent dioxygenases plays essential roles in development of ovarian serous carcinoma (OV). However, the molecular profiles of AlkB family in OV have not been clarified.
Yuan Cai +6 more
semanticscholar +4 more sources
Novel AlkB dioxygenases--alternative models for in silico and in vivo studies.
PLoS ONE, 2012 BackgroundALKBH proteins, the homologs of Escherichia coli AlkB dioxygenase, constitute a direct, single-protein repair system, protecting cellular DNA and RNA against the cytotoxic and mutagenic activity of alkylating agents, chemicals significantly ...
Damian Mielecki +8 more
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The Use of a Combination of alkB Primers to Better Characterize the Distribution of Alkane-Degrading Bacteria. [PDF]
PLoS ONE, 2013 The alkane monooxygenase AlkB, which is encoded by the alkB gene, is a key enzyme involved in bacterial alkane degradation. To study the alkB gene within bacterial communities, researchers need to be aware of the variations in alkB nucleotide sequences ...
Diogo Jurelevicius +4 more
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Substrate specificities of bacterial and human AlkB proteins [PDF]
Nucleic Acids Research, 2004 Methylating agents introduce cytotoxic 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) residues into nucleic acids, and it was recently demonstrated that the Escherichia coli AlkB protein and two human homologues, hABH2 and hABH3, can remove these lesions from DNA by oxidative demethylation. Moreover, AlkB and hABH3 were also found to remove 1-meA
Pål Ø. Falnes +4 more
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