Results 21 to 30 of about 6,739 (216)
AlkB Restores the Biological Function of mRNA and tRNA Inactivated by Chemical Methylation [PDF]
Molecular Cell, 2004 Deleterious 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions are introduced into nucleic acids by methylating agents. It was recently demonstrated that the E. coli AlkB protein and a human homolog, hABH3, can demethylate these lesions both in DNA and RNA.
Rune F. Johansen +7 more
openaire +5 more sources
Angewandte Chemie International Edition, Accepted Article.The α‐methylene‐γ‐butyrolactone tulipalin A, a defense compound found in tulips, can polymerize via addition at the vinyl group or via ring‐opening polymerization, making it a highly promising monomer for bio‐based polymers. Since the biosynthesis of tulipalin A in plants remains elusive, we propose an alternative pathway for its synthesis starting ...
Andrea Nigl +11 more
wiley +2 more sources
Therapeutic potential of ALKB homologs for cardiovascular disease.
Biomedicine & Pharmacotherapy, 2020 Cardiovascular diseases (CVDs) are the leading causes of human death. Recently, ALKB homologs, including ALKBH1-8 and FTO, have been found to have a variety of biological functions, such as histone demethylation, RNA demethylation, and DNA demethylation.
Mingzhu Xiao +5 more
semanticscholar +4 more sources
Repair of Methylation Damage in DNA and RNA by Mammalian AlkB Homologues [PDF]
Journal of Biological Chemistry, 2005 Human and Escherichia coli derivatives of AlkB enzymes remove methyl groups from 1-methyladenine and 3-methylcytosine in nucleic acids via an oxidative mechanism that releases the methyl group as formaldehyde. In this report, we demonstrate that the mouse homologues of the alpha-ketoglutarate Fe(II) oxygen-dependent enzymes mAbh2 and Abh3 have ...
Lee, Dong-Hyun +5 more
openaire +6 more sources
Cloning and Expression of Pseudomonas aeruginosa AlkB Gene in E. coli
Journal of Pure and Applied Microbiology, 2020 Pre identified hydrocarbons degrading bacteria were used in this study, specific primer was conducted to amplification of AlkB gene, approximately 1206bp band size of this gene for Pseudomonas aeruginosa was detected and proofed by sequence and ...
Fadhil N. Al-Kanany, Rasha M. Othman
doaj +3 more sources
Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins [PDF]
DNA Repair, 2015 AlkB proteins are evolutionary conserved Fe(II)/2-oxoglutarate-dependent dioxygenases, which remove alkyl and highly promutagenic etheno(ɛ)-DNA adducts, but their substrate specificity has not been fully determined. We developed a novel assay for the repair of ɛ-adducts by AlkB enzymes using oligodeoxynucleotides with a single lesion and specific DNA ...
Pål Ø. Falnes +9 more
openaire +4 more sources
Influence of compost amendments on the diversity of alkane degrading bacteria in hydrocarbon contaminated soils [PDF]
Frontiers in Microbiology, 2014 Alkane degrading microorganisms play an important role for bioremediation of petrogenic contaminated environments. In this study, we investigated the effects of compost addition on the diversity of alkane monooxygenase gene (alkB) harboring bacteria in ...
Michael eSchloter
doaj +2 more sources
Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets.
Journal of Medicinal Chemistry, 2021 The AlkB family of nucleic acid demethylases is currently of intense chemical, biological, and medical interest because of its critical roles in several key cellular processes, including epigenetic gene regulation, RNA metabolism, and DNA repair ...
Gemma S Perry, Mohua Das, E. Woon
semanticscholar +4 more sources
Viral AlkB proteins repair RNA damage by oxidative demethylation [PDF]
Nucleic Acids Research, 2008 Bacterial and mammalian AlkB proteins are iron(II)- and 2-oxoglutarate-dependent dioxygenases that reverse methylation damage, such as 1-methyladenine and 3-methylcytosine, in RNA and DNA. An AlkB-domain is encoded by the genome of numerous single-stranded, plant-infecting RNA viruses, the majority of which belong to the Flexiviridae family.
Vibeke Leihne +6 more
openaire +4 more sources
AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells [PDF]
Scientific Reports, 2017 The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein catalyzes the oxidative demethylation of 1-methyladenine (1-meA) and 3 ...
Yuko Ueda +9 more
semanticscholar +2 more sources