Results 21 to 30 of about 10,817 (260)
DNA, 2023 Nucleic acid methylations are important genetic and epigenetic biomarkers. The formation and removal of these markers is related to either methylation or demethylation.
Zhiyuan Peng +5 more
doaj +2 more sources
Novel AlkB dioxygenases--alternative models for in silico and in vivo studies.
PLoS ONE, 2012 BackgroundALKBH proteins, the homologs of Escherichia coli AlkB dioxygenase, constitute a direct, single-protein repair system, protecting cellular DNA and RNA against the cytotoxic and mutagenic activity of alkylating agents, chemicals significantly ...
Damian Mielecki +8 more
doaj +5 more sources
Cloning and Expression of Pseudomonas aeruginosa AlkB Gene in E. coli
Journal of Pure and Applied Microbiology, 2020 Pre identified hydrocarbons degrading bacteria were used in this study, specific primer was conducted to amplification of AlkB gene, approximately 1206bp band size of this gene for Pseudomonas aeruginosa was detected and proofed by sequence and ...
Fadhil N. Al-Kanany, Rasha M. Othman
doaj +3 more sources
Therapeutic potential of ALKB homologs for cardiovascular disease.
Biomedicine & Pharmacotherapy, 2020 Cardiovascular diseases (CVDs) are the leading causes of human death. Recently, ALKB homologs, including ALKBH1-8 and FTO, have been found to have a variety of biological functions, such as histone demethylation, RNA demethylation, and DNA demethylation.
Mingzhu Xiao +5 more
semanticscholar +4 more sources
Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets.
Journal of Medicinal Chemistry, 2021 The AlkB family of nucleic acid demethylases is currently of intense chemical, biological, and medical interest because of its critical roles in several key cellular processes, including epigenetic gene regulation, RNA metabolism, and DNA repair ...
Gemma S Perry, Mohua Das, E. Woon
semanticscholar +4 more sources
The Selectivity and Inhibition of AlkB [PDF]
Journal of Biological Chemistry, 2003 AlkB is one of four proteins involved in the adaptive response to DNA alkylation damage in Escherichia coli and is highly conserved from bacteria to humans. Recent analyses have verified the prediction that AlkB is a member of the Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenase family of enzymes.
Richard W.D. Welford +4 more
openalex +6 more sources
Engineering of Transmembrane Alkane Monooxygenases to Improve a Key Reaction Step in the Synthesis of Polymer Precursor Tulipalin A. [PDF]
Angew Chem Int Ed EnglA biosynthesis route for the polymer precursor tulipalin A starting from isoprenyl acetate is proposed. The alkane monooxygenase AlkB catalyzes the chemoselective terminal hydroxylation of isoprenyl acetate. Rational enzyme engineering further increased the activity of the membrane enzyme.
Nigl A +11 more
europepmc +3 more sources
Substrate specificities of bacterial and human AlkB proteins [PDF]
Nucleic Acids Research, 2004 Methylating agents introduce cytotoxic 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) residues into nucleic acids, and it was recently demonstrated that the Escherichia coli AlkB protein and two human homologues, hABH2 and hABH3, can remove these lesions from DNA by oxidative demethylation. Moreover, AlkB and hABH3 were also found to remove 1-meA
Pål Ø. Falnes
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AlkB Restores the Biological Function of mRNA and tRNA Inactivated by Chemical Methylation [PDF]
Molecular Cell, 2004 Deleterious 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions are introduced into nucleic acids by methylating agents. It was recently demonstrated that the E. coli AlkB protein and a human homolog, hABH3, can demethylate these lesions both in DNA and RNA.
Rune Ougland +7 more
openalex +5 more sources
PlantsSoybean (Glycine max (L.) Merr) is one of the most important crops worldwide, but its yield is vulnerable to abiotic stresses. In Arabidopsis, the AlkB homologue (ALKBH) family genes plays a crucial role in plant development and stress response. However,
Jie Zhao +8 more
openalex +2 more sources