Role of the viral AlkB homologs in RNA repair [PDF]
, 2014 AlkB proteins that repair DNA via reversing methylation damage are conserved in a broad range of prokaryotes and eukaryotes including plants. Surprisingly, AlkB-domains were discovered in the genomes of numerous plant positive-strand RNA viruses, majority of which belong to the family Flexiviridae. The major goal of this research was to reveal the AlkB
Munir Mawassi, Valerian V. Dolja
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AlkB Homologue 2–Mediated Repair of Ethenoadenine Lesions in Mammalian DNA [PDF]
Cancer Research, 2008 Abstract Endogenous formation of the mutagenic DNA adduct 1,N6-ethenoadenine (εA) originates from lipid peroxidation. Elevated levels of εA in cancer-prone tissues suggest a role for this adduct in the development of some cancers. The base excision repair pathway has been considered the principal repair system for εA lesions until ...
Jeanette Ringvoll +10 more
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Structural and mutational analysis of Escherichia coli AlkB provides insight into substrate specificity and DNA damage searching. [PDF]
PLoS ONE, 2010 BACKGROUND: In Escherichia coli, cytotoxic DNA methyl lesions on the N1 position of purines and N3 position of pyrimidines are primarily repaired by the 2-oxoglutarate (2-OG) iron(II) dependent dioxygenase, AlkB.
Paul J Holland, Thomas Hollis
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The Selectivity and Inhibition of AlkB [PDF]
Journal of Biological Chemistry, 2003 AlkB is one of four proteins involved in the adaptive response to DNA alkylation damage in Escherichia coli and is highly conserved from bacteria to humans. Recent analyses have verified the prediction that AlkB is a member of the Fe(II) and 2-oxoglutarate (2OG)-dependent oxygenase family of enzymes.
Welford, R +4 more
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A novel alkane monooxygenase (alkB) clade revealed by massive genomic survey and its dissemination association with IS elements [PDF]
PeerJ, 2022 Background Alkanes are important components of fossil energy, such as crude oil. The alkane monooxygenase encoded by alkB gene performs the initial step of alkane degradation under aerobic conditions.
Shaojing Wang +4 more
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Structure and function prediction of human homologue hABH5 of _E. coli_ ALKB5 using in silico approach [PDF]
, 2011 Newly discovered human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Little is known about the structure and function of hABH5, one of the members of this superfamily.
Ambarish Sharan Vidyarthi +2 more
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Therapeutic potential of ALKB homologs for cardiovascular disease
Biomedicine & Pharmacotherapy, 2020 Cardiovascular diseases (CVDs) are the leading causes of human death. Recently, ALKB homologs, including ALKBH1-8 and FTO, have been found to have a variety of biological functions, such as histone demethylation, RNA demethylation, and DNA demethylation.
Mingzhu Xiao +5 more
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Non-homologous functions of the AlkB homologs [PDF]
Journal of Molecular Cell Biology, 2015 The DNA repair enzyme AlkB was identified in E. coli more than three decades ago. Since then, nine mammalian homologs, all members of the superfamily of alpha-ketoglutarate and Fe(II)-dependent dioxygenases, have been identified (designated ALKBH1-8 and FTO). While E.
Rune, Ougland +3 more
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Growth of Rhodococcus sp. strain BCP1 on gaseous n-alkanes: New metabolic insights and transcriptional analysis of two soluble di-iron monooxygenase genes [PDF]
, 2015 Rhodococcus sp. strain BCP1 was initially isolated for its ability to grow on gaseous n-alkanes, which act as inducers for the co-metabolic degradation of low-chlorinated compounds.
Cappelletti M. +6 more
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Suppression of Escherichia coli alkB mutants by Saccharomyces cerevisiae genes [PDF]
Journal of Bacteriology, 1995 The alkB gene is one of a group of alkylation-inducible genes in Escherichia coli, and its product protects cells from SN2-type alkylating agents such as methyl methanesulfonate (MMS). However, the precise biochemical function of the AlkB protein remains unknown.
Y F Wei, Bao‐Ji Chen, Leona D. Samson
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