AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells [PDF]
Scientific Reports, 2017 The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein catalyzes the oxidative demethylation of 1-methyladenine (1-meA) and 3 ...
Yuko Ueda +9 more
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Repair of Methylation Damage in DNA and RNA by Mammalian AlkB Homologues [PDF]
Journal of Biological Chemistry, 2005 Human and Escherichia coli derivatives of AlkB enzymes remove methyl groups from 1-methyladenine and 3-methylcytosine in nucleic acids via an oxidative mechanism that releases the methyl group as formaldehyde. In this report, we demonstrate that the mouse homologues of the alpha-ketoglutarate Fe(II) oxygen-dependent enzymes mAbh2 and Abh3 have ...
Dong-Hyun Lee +5 more
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DNA repair by bacterial AlkB proteins
Research in Microbiology, 2003 The Escherichia coli AlkB protein is an iron- and 2-oxoglutarate-dependent oxygenase, repairing 1-methyladenine and 3-methylcytosine lesions in DNA. AlkB homologues are present in a number of bacterial species, and some bacteria have two different AlkB proteins.
Pål Ø. Falnes, Torbjørn Rognes
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Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins [PDF]
DNA Repair, 2015 AlkB proteins are evolutionary conserved Fe(II)/2-oxoglutarate-dependent dioxygenases, which remove alkyl and highly promutagenic etheno(ɛ)-DNA adducts, but their substrate specificity has not been fully determined. We developed a novel assay for the repair of ɛ-adducts by AlkB enzymes using oligodeoxynucleotides with a single lesion and specific DNA ...
Daria Zdżalik-Bielecka +8 more
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Genome-wide identification and characterization of ALKB homolog gene family in wheat (<i>Triticum aestivum L.</i>). [PDF]
Front Plant SciWang P +6 more
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Structural and mutational analysis of Escherichia coli AlkB provides insight into substrate specificity and DNA damage searching. [PDF]
PLoS ONE, 2010 BACKGROUND: In Escherichia coli, cytotoxic DNA methyl lesions on the N1 position of purines and N3 position of pyrimidines are primarily repaired by the 2-oxoglutarate (2-OG) iron(II) dependent dioxygenase, AlkB.
Paul J Holland, Thomas Hollis
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Structure and function prediction of human homologue hABH5 of _E. coli_ ALKB5 using in silico approach [PDF]
, 2011 Newly discovered human homologues of ALKB protein have shown the activity of DNA damaging drugs, used for cancer therapy. Little is known about the structure and function of hABH5, one of the members of this superfamily.
Ambarish Sharan Vidyarthi +3 more
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The AlkB Homolog SlALKBH10B Negatively Affects Drought and Salt Tolerance in Solanum lycopersicum
International Journal of Molecular Sciences, 2023 ALKBH proteins, the homologs of Escherichia coli AlkB dioxygenase, constitute a single-protein repair system that safeguards cellular DNA and RNA against the harmful effects of alkylating agents.
Hui Shen +6 more
semanticscholar +1 more source
Non-homologous functions of the AlkB homologs [PDF]
Journal of Molecular Cell Biology, 2015 The DNA repair enzyme AlkB was identified in E. coli more than three decades ago. Since then, nine mammalian homologs, all members of the superfamily of alpha-ketoglutarate and Fe(II)-dependent dioxygenases, have been identified (designated ALKBH1-8 and FTO). While E.
Rune Ougland +3 more
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Chinese journal of physiology, 2023 Prostate cancer (PCa) is one of the leading causes of cancer-related death in males worldwide and exploring more reliable biomarkers for PCa is essential for the diagnosis and therapeutics for the disease.
Xun Li +4 more
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