Results 161 to 170 of about 1,546 (186)

MPN- and Real-Time-Based PCR Methods for the Quantification of Alkane Monooxygenase Homologous Genes (alkB) in Environmental Samples

2009
Hydrocarbons are major contaminants of soil ecosystems as a result of uncontrolled oil spills and wastes disposal into the environment. Ecological risk assessment and remediation of affected sites is often constrained due to lack of suitable prognostic and diagnostic tools that provide information of abiotic-biotic interactions occurring between ...
Alfredo, Pérez-de-Mora, Stephan, Schulz, Michael, Schloter   +2 more
openaire   +2 more sources

Abundance and Diversity of n-Alkane-Degrading Bacteria in a Forest Soil Co-Contaminated with Hydrocarbons and Metals: A Molecular Study on alkB Homologous Genes

Microbial Ecology, 2011
Unraveling functional genes related to biodegradation of organic compounds has profoundly improved our understanding of biological remediation processes, yet the ecology of such genes is only poorly understood. We used a culture-independent approach to assess the abundance and diversity of bacteria catalyzing the degradation of n-alkanes with a chain ...
Alfredo, Pérez-de-Mora, Marion, Engel, Michael, Schloter   +2 more
openaire   +2 more sources

High expression of AlkB homolog 5 suppresses the progression of non‐small cell lung cancer by facilitating ferroptosis through m6A demethylation of SLC7A11

Environmental Toxicology
AbstractObjectiveNon‐small cell lung cancer (NSCLC) is a prevailing LC characterized by poor outcomes. AlkB homolog 5 (ALKBH5) functions as a tumor suppressor in several cancers. This study delved into the role of ALKBH5 in NSCLC development.MethodsTCGA database predicted ALKBH5 expression in NSCLC patients.
Zhangzhou Huang, Gen Lin, Yaping Hong, Lihong Weng, Kai Zhu, Wu Zhuang   +5 more
openalex   +3 more sources

KIAA1429 and AlkB Homolog 5 Regulate Bladder Cancer Progression via N⁶‐Methyladenosine‐Dependent Modulation of Sonic Hedgehog Signaling

Molecular Carcinogenesis
ABSTRACTN6‐methyladenosine (m6A) modification plays a pivotal role in cancer progression, yet its regulatory mechanisms in bladder cancer (BCa) remain poorly understood. This study investigates the functions of two key m6A regulators—α‐ketoglutarate‐dependent dioxygenase alkB homolog 5 (ALKBH5) and KIAA1429—in modulating BCa cell behavior.
Zhimin Jiao, Xiaowu Liu, Xiaoliang Yuan, Xugang Wang, Qinyu Xu, Wu Haoran   +5 more
openalex   +2 more sources

Structure and mechanism of the alkane-oxidizing enzyme AlkB

Nature Communications, 2023
Jianxiu Zhang, , Rachel Narehood Austin
exaly  

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

Nature, 2002
Robert P Hausinger
exaly  

AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli

Nature, 2002
Pål Ø Falnes
exaly  

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA

Nature, 2008
Cai-Guang Yang, Chengqi Yi, Xing Jian
exaly  

Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB

Nature, 2006
Brian R Gibney
exaly  

Theory Uncovers an Unusual Mechanism of DNA Repair of a Lesioned Adenine by AlkB Enzymes

Journal of the American Chemical Society, 2014
Binju Wang, Dandamudi Usharani, Chunsen Li   +2 more
exaly