Results 51 to 60 of about 110,088 (171)

The homology digraph of a preordered space [PDF]

arXiv, 2023
This paper studies a notion of directed homology for preordered spaces, called the homology digraph. We show that the homology digraph is a directed homotopy invariant and establish variants of the main results of ordinary singular homology theory for the homology digraph.
arxiv  

DNA direct reversal repair and alkylating agent drug resistance

Cancer Drug Resistance, 2021
DNA direct reversal repair (DRR) is unique in that no DNA synthesis is required to correct the error and therefore repair via such mechanisms are error-free.
Roberto Gutierrez, T. O'Connor
semanticscholar   +1 more source

Drosophila Alpha-ketoglutarate-dependent dioxygenase AlkB is involved in repair from neuronal disorders induced by ultraviolet damage.

NeuroReport, 2019
AlkB family proteins are enzymes that repair alkylated DNA and RNA by oxidative demethylation. Nine homologs have been identified and characterized in mammals. ALKBH1 is conserved among metazoans including Drosophila.
K. Wakisaka, Yuuka Muraoka, J. Shimizu, Mizuki Yamaguchi, Ibuki Ueoka, I. Mizuta, H. Yoshida, M. Yamaguchi   +7 more
semanticscholar   +1 more source

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

Genome Biology, 2001
BackgroundProtein fold recognition using sequence profile searches frequently allows prediction of the structure and biochemical mechanisms of proteins with an important biological function but unknown biochemical activity.
L. Aravind, E. Koonin
semanticscholar   +1 more source

Selected ALKBH dioxygenases are overexpressed in salivary gland tumours.

Acta Biochimica Polonica, 2022
Salivary gland tumours (SGTs) are a heterogeneous group of benign tumours of various origins and pathologies, showing a number of DNA modifications. Previously, in malignant head and neck cancer (HNSCC), we found overexpression of ALKBH proteins, the ...
Michał Marcinkowski, D. Garbicz, Tomasz Pilżys, W. Kukwa, E. Grzesiuk   +4 more
semanticscholar   +1 more source

m6A‐Mediated TMCO3 Promotes Hepatocellular Carcinoma Progression by Facilitating the Membrane Translocation and Activation of AKT

Advanced Science, EarlyView.
TMCO3 as a downstream target of ALKBH5 is found, which regulates its expression in an m6A‐dependent manner, and then a new phosphorylation site on TMCO3 is identified and determines the specific mechanism of TMCO3 with AKT. Moreover, the combined treatment of targeting the TMCO3 and inhibition of AKT in mice models with HCC achieves great results ...
Xinxin Li, Mengzhen Han, He Zhu, Yonglong Pan, Chen Su, Yachong Liu, Zhibin Liao, Bixiang Zhang, Xiaoping Chen   +8 more
wiley   +1 more source

MdDSK2a‐Like‐MdMTA Module Functions in Apple Cold Response via Regulating ROS Detoxification and Cell Wall Deposition

Advanced Science, EarlyView.
Under cold stress, MdDSK2a‐like is degraded via the 26S proteasome pathway, thereby alleviating the degradation of MdMTA induced by the 26S proteasome and autophagy pathways mediated by MdDSK2a‐like. The accumulated MdMTA increases the m6A levels of cold‐responsive genes, thereby contributing to increased ROS detoxification, deposition of cell wall, as
Nan Hou, Jieqiang He, Chana Bao, Fang Zhi, Xiaoxia Shen, Yu Liu, Chaoshuo Li, Tianle Fan, Xinyue Yang, Baohua Chu, Gege Qin, Zeyuan Liu, Chuang Mei, Bin Tan, Jiancan Feng, Fengwang Ma, Mickael Malnoy, Xuewei Li, Qingmei Guan   +18 more
wiley   +1 more source

Characterization of human ALKBH4 – an AlkB homolog with a possible function in gene regulation

, 2013
Linn G. Bjørnstad
openalex   +3 more sources

Minimal Methylated Substrate and Extended Substrate Range of Escherichia coli AlkB Protein, a 1-Methyladenine-DNA Dioxygenase*

Journal of Biological Chemistry, 2003
The Escherichia coli AlkB protein, and two human homologs ABH2 and ABH3, directly demethylate 1-methyladenine and 3-methylcytosine in DNA. They couple Fe(II)-dependent oxidative demethylation of these damaged bases to decarboxylation of α-ketoglutarate ...
P. Koivisto, T. Duncan, T. Lindahl, B. Sedgwick   +3 more
semanticscholar   +1 more source

Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a “hit‐and‐run” paradigm

Cancer Communications, EarlyView.
Abstract Background Helicobacter pylori (H. pylori) infection contributes significantly to gastric cancer (GC) progression. The intrinsic mechanisms of H. pylori‐host interactions and their role in promoting GC progression need further investigation.
Bing He, Yiyang Hu, Yuyun Wu, Chao Wang, Limin Gao, Chunli Gong, Zhibin Li, Nannan Gao, Huan Yang, Yufeng Xiao, Shiming Yang   +10 more
wiley   +1 more source