Characterization of human ALKBH4 – an AlkB homolog with a possible function in gene regulation
, 2013 Linn G. Bjørnstad
openalex +3 more sources
Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
Journal of Nucleic Acids, 2010 DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex ...
Bo Hang
doaj +1 more source
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA [PDF]
, 2011 Mammals have nine different homologues (ALKBH1–9) of the Escherichia coli DNA repair demethylase AlkB. ALKBH2 is a genuine DNA repair enzyme, but the in vivo function of the other ALKBH proteins has remained elusive.
Falnes, P. O. +10 more
core +1 more source
Sequence Dependent Repair of 1,N6-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB [PDF]
, 2021 Mutation patterns of DNA adducts, such as mutational spectra and signatures, are useful tools for diagnostic and prognostic purposes. Mutational spectra of carcinogens derive from three sources: adduct formation, replication bypass, and repair.
Bian, Ke +5 more
core +2 more sources
Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB [PDF]
, 2014 The structurally related exocyclic guanine adducts α-hydroxypropano-dG (α-OH-PdG), γ-hydroxypropano-dG (γ-OH-PdG), and M[subscript 1]dG are formed when DNA is exposed to the reactive aldehydes acrolein and malondialdehyde (MDA).
Delaney, James C. +8 more
core +3 more sources
Molecular modelling and Function Prediction of hABH7, human homologue of _E. coli_ ALKB7 [PDF]
, 2011 Human homologues of ALKB protein have shown the prime role in DNA damaging drugs, used for cancer therapy. Little is known about structure and function of hABH7, one of the members of this superfamily. Therefore, in the present study we intend to predict
Ambarish Sharan Vidyarthi +2 more
core +1 more source
Aerobic growth of Rhodococcus aetherivorans BCP1 using selected naphthenic acids as the sole carbon and energy sources [PDF]
, 2018 Naphthenic acids (NAs) are an important group of toxic organic compounds naturally occurring in hydrocarbon deposits. This work shows that Rhodococcus aetherivorans BCP1 cells not only utilize a mixture of eight different NAs (8XNAs) for growth but they ...
Cappelletti M. +12 more
core +2 more sources
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Mechanisms of DNA damage, repair, and mutagenesis [PDF]
, 2017 Living organisms are continuously exposed to a myriad of DNA damaging agents that can impact health and modulate disease-states. However, robust DNA repair and damage-bypass mechanisms faithfully protect the DNA by either removing or tolerating the ...
Chatterjee, Nimrat, Walker, Graham C
core +1 more source