Results 61 to 70 of about 110,088 (171)

Bacterial DNA repair genes and their eukaryotic homologues: 3. AlkB dioxygenase and Ada methyltransferase in the direct repair of alkylated DNA.

Acta Biochimica Polonica, 2007
Environmental and endogenous alkylating agents generate cytotoxic and mutagenic lesions in DNA. Exposure of prokaryotic cells to sublethal doses of DNA alkylating agents induces so called adaptive response (Ada response) involving the expression of a set
J. Nieminuszczy, E. Grzesiuk
semanticscholar   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.

Nucleic Acids Research, 2004
The Escherichia coli AlkB protein was recently found to repair cytotoxic DNA lesions 1-methyladenine and 3-methylcytosine by using a novel iron-catalyzed oxidative demethylation mechanism.
Y. Mishina, Chih-Hui J Lee, Chuan He
semanticscholar   +1 more source

The GntR/VanR transcription regulator AlkR represses AlkB2 monooxygenase expression and regulates n‐alkane degradation in Pseudomonas aeruginosa SJTD‐1

mLife, EarlyView.
Abstract Transmembrane alkane monooxygenase (AlkB)‐type monooxygenases, especially AlkB2 monooxygenases, are crucial for aerobic degradation of the medium‐to‐long‐chain n‐alkanes in hydrocarbon‐utilizing microorganisms. In this study, we identified a GntR/VanR transcription regulator AlkR of Pseudomonas aeruginosa SJTD‐1 involved in the negative ...
Wanli Peng, Xiuli Wang, Qinchen Liu, Zhihong Xiao, Fulin Li, Nannan Ji, Zhuo Chen, Jiaying He, Junhao Wang, Zixin Deng, Shuangjun Lin, Rubing Liang   +11 more
wiley   +1 more source

Human and Arabidopsis alpha‐ketoglutarate‐dependent dioxygenase homolog proteins—New players in important regulatory processes

IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2020
The family of AlkB homolog (ALKBH) proteins, the homologs of Escherichia coli AlkB 2‐oxoglutarate (2OG), and Fe(II)‐dependent dioxygenase are involved in a number of important regulatory processes in eukaryotic cells including repair of alkylation ...
Michał Marcinkowski, Tomasz Pilżys, D. Garbicz, Jaroslaw Steciuk, D. Zugaj, D. Mielecki, T. Sarnowski, E. Grzesiuk   +7 more
semanticscholar   +1 more source

Site‐specific m6A‐miR‐494‐3p, not unmethylated miR‐494‐3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis

British Journal of Pharmacology, EarlyView.
Background and Purpose Intracranial atherosclerosis is one of the most common causes of ischaemic stroke. However, there is a substantial knowledge gap on the development of intracranial atherosclerosis. Intracranial arteries are characterized by an upregulation of tight junctions between endothelial cells, which control endothelial permeability.
Tamar Woudenberg, M. Leontien van der Bent, Veerle Kremer, Ingeborg S. E. Waas, Mat J. A. P. Daemen, Reinier A. Boon, Paul H. A. Quax, A. Yaël Nossent   +7 more
wiley   +1 more source

Prediction of the molecular boundary and functionality of novel viral AlkB domains using homology modelling and principal component analysis

Journal of General Virology, 2019
Alkylation B (AlkB) proteins are ubiquitous among diverse cellular organisms, where they act to reverse the damage in DNA and RNA due to methylation, such as 1-methyladenine and 3-methylcytosine. This process is found in virtually all forms of life, with the notable exception of archaea and yeast.
Clayton Moore, Baozhong Meng
openaire   +3 more sources

Inhibition of Alkbh5 Attenuates Lipopolysaccharide‐Induced Lung Injury by Promoting Ccl1 m6A and Treg Recruitment

Cell Proliferation, EarlyView.
In septic lung injury mice, Alkbh5 is highly expressed, promoting the demethylation of m6A on Ccl1 mRNA, thereby reducing the stability of Ccl1 mRNA and decreasing Ccl1 expression. This, in turn, leads to reduced recruitment of Tregs, further exacerbating the symptoms of septic lung injury.
Hongdou Ding, Xinnan Xu, Yaoyao Zhu, Xinyu Ling, Li Xu   +4 more
wiley   +1 more source

The m6A demethylase FTO promotes C/EBPβ‐LIP translation to perform oncogenic functions in breast cancer cells

The FEBS Journal, EarlyView.
N6‐methyladenosine is a key mRNA modification that regulates transcript turnover, translation, and other aspects of RNA fate. The m6A‐demethylase ‘eraser’ enzyme FTO reverses this modification. While FTO is known to promote oncogenic signaling in triple‐negative breast cancer, its wider role across the genome and specific downstream signaling has yet ...
Hidde R. Zuidhof, Christine Müller, Gertrud Kortman, René Wardenaar, Ekaterina Stepanova, Fabricio Loayza‐Puch, Cornelis F. Calkhoven   +6 more
wiley   +1 more source

Evolution and diversity of the 2-oxoglutarate-dependent dioxygenase superfamily in plants.

The Plant Journal, 2014
The 2-oxoglutarate-dependent dioxygenase (2OGD) superfamily is the second largest enzyme family in the plant genome, and its members are involved in various oxygenation/hydroxylation reactions.
Y. Kawai, Eiichiro Ono, M. Mizutani
semanticscholar   +1 more source