Results 81 to 90 of about 1,546 (186)

Air Pollution‐Induced Epigenetic Regulation in Respiratory Diseases: Mechanisms, Dysregulation, and Therapeutic Opportunities

MedComm – Future Medicine, Volume 4, Issue 4, December 2025.
Air pollution, a major global health hazard, contributes to asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and lung cancer via four core epigenetic pathways (DNA/RNA methylation, noncoding RNAs, and histone modifications), shaping gene expression and driving disease pathogenesis.
Ruitong Zeng, Jiliu Liu, Guoping Li, Junyi Wang, Anying Xiong, Ying Xiong, Xiang He   +6 more
wiley   +1 more source

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by the MLL Partner TET1 [PDF]

, 2009
DNA cytosine methylation is crucial for retrotransposon silencing and mammalian development. In a computational search for enzymes that could modify 5-methylcytosine (5mC), we identified TET proteins as mammalian homologs of the trypanosome proteins JBP1
Agarwal, Suneet, Aravind, L, Bandukwala, Hozefa S, Brudno, Yevgeny, Iyer, Lakshminarayan M., Koh, Kian Peng, Liu, David Ruchien, Pastor, William Abraham, Rao, Anjana, Shen, Yinghua, Tahiliani, Mamta V.   +10 more
core   +1 more source

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

Decreased M6A Modification Promotes Progression of Gastrointestinal Stromal Tumor and KIT‐Derived Imatinib Resistance Through FTO‐Regulated Axis

MedComm – Oncology, Volume 4, Issue 4, December 2025.
The study identifies decreased m6A levels, FTO and lncRNA XIST as critical oncogenic molecules in gastrointestinal stromal tumor (GIST) progression and imatinib resistance, both in vitro and in vivo. FTO modulates m6A modification levels in GIST, leading to the stabilization of lncRNA XIST and promotion of KIT expression. Posttranscriptional regulation
Jiehan Li, Ge Zhang, Yizheng Zhang, Zhao Sun, Wunan Mi, Meimei Jiang, Guiyun Jia, Nannan Liu, Lingling Zhang, Zhenqiang Sun, Jianwu Jiang, Yingjie Zhang, Yang Fu   +12 more
wiley   +1 more source

Rewriting the MASLD‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism

International Journal of Cancer, Volume 157, Issue 10, Page 1991-2003, 15 November 2025.
Abstract Abnormal epigenetic patterns are crucial for the progression of metabolic‐associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC) development. Recent research focused on the interplay between epigenetics and altered metabolic pathways in HCC from MASLD, suggesting that the reversibility of epigenetic changes offers ...
Chiara Aiello, Eric Felli, Teresa Musarra, Lorenzo Nevi, Annamaria Altomare, Jordi Gracia‐Sancho, Andrea Baiocchini, Simone Carotti   +7 more
wiley   +1 more source

Prediction of the molecular boundary and functionality of novel viral AlkB domains using homology modelling and principal component analysis

Journal of General Virology, 2019
Alkylation B (AlkB) proteins are ubiquitous among diverse cellular organisms, where they act to reverse the damage in DNA and RNA due to methylation, such as 1-methyladenine and 3-methylcytosine. This process is found in virtually all forms of life, with the notable exception of archaea and yeast.
Clayton, Moore, Baozhong, Meng
openaire   +2 more sources

Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, Volume 45, Issue 11, Page 1367-1406, November 2025.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zeng, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source

Transcriptomic Analyses Unveil Hydrocarbon Degradation Mechanisms in a Novel Polar Rhodococcus sp. Strain R1B_2T From a High Arctic Intertidal Zone Exposed to Ultra‐Low Sulphur Fuel Oil

Environmental Microbiology Reports, Volume 17, Issue 5, October 2025.
Cold‐adapted Rhodococcus sp. strain R1B_2T from Arctic Tupirvik Beach (Northwest Passage) degrades short‐ to long‐chain hydrocarbons in summer seawater (−1°C to 5°C) via a synergistic activity of key hydrocarbon degradation genes (alkB, CYP153, almA, and ladA), with rhlABCR‐linked rhamnolipid production supporting biodegradation.
Nastasia J. Freyria, Antoine‐Olivier Lirette, Brady R. W. O'Connor, Charles W. Greer, Lyle G. Whyte   +4 more
wiley   +1 more source

DNA repair in cancer: emerging targets for personalized therapy [PDF]

, 2014
Genomic deoxyribonucleic acid (DNA) is under constant threat from endogenous and exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity.
Abbotts, Rachel, Madhusudan, Srinivasan, Thompson, Nicola   +2 more
core   +3 more sources

Delving Into the Dialogue between Epigenetic Modifications and Immunometabolism in Cancer

Advanced Genetics, Volume 6, Issue 3, September 2025.
Epigenetic modifications—including DNA, histone, and RNA modifications—and their interplay play pivotal roles in tumorigenesis and progression. The crosstalk between tumor immunometabolism and epigenetic regulation has garnered significant attention, as metabolites serve as epigenetic modulators to modulate immune cell activation, differentiation, and ...
Xiaowen Xie, Weici Liu, Pengpeng Zhang, Peng Luo, Bufu Tang, Wenjun Mao   +5 more
wiley   +1 more source