Results 151 to 160 of about 2,197 (160)
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Bioorganic and Medicinal Chemistry Letters, 2014
A series of 1-aryl-3,4-substituted-1H-pyrazol-5-ol derivatives was synthesized and evaluated as prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors to obtain a novel anti-prostate cancer drug. After modifying 1-(1H-benzimidazol-2-yl)-3,4-dimethyl-1H-pyrazol-5-ol (1), a hit compound found during random screening using a recombinant PCA-1/ALKBH3, 1-(1H-5-
Tatsuhiko Furukawa, Kazutake Tsujikawa
exaly +3 more sources
A series of 1-aryl-3,4-substituted-1H-pyrazol-5-ol derivatives was synthesized and evaluated as prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors to obtain a novel anti-prostate cancer drug. After modifying 1-(1H-benzimidazol-2-yl)-3,4-dimethyl-1H-pyrazol-5-ol (1), a hit compound found during random screening using a recombinant PCA-1/ALKBH3, 1-(1H-5-
Tatsuhiko Furukawa, Kazutake Tsujikawa
exaly +3 more sources
Small
Organic photoelectrochemical transistor (OPECT) biosensors have emerged as prevalent candidates for bioanalytical technologies because of their intrinsic amplification properties and excellent detection performance.
Yixin Hu +7 more
semanticscholar +1 more source
Organic photoelectrochemical transistor (OPECT) biosensors have emerged as prevalent candidates for bioanalytical technologies because of their intrinsic amplification properties and excellent detection performance.
Yixin Hu +7 more
semanticscholar +1 more source
ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals [PDF]
Clinical Cancer Research, 2012 Abstract Purpose: The role and function of a novel human AlkB homologue, ALKBH3, in human urothelial carcinoma development were examined. Experimental design: Biologic roles of ALKBH3 were examined by gene silencing analysis using in vitro and in vivo siRNA transfection. Immunohistochemical analyses of ALKBH3 and the
Keiji Shimada
exaly +3 more sources
Anti-Cancer Drugs
Prostate cancer antigen-1/ALKBH3, a DNA/RNA demethylase of 3-methylcytosine, 1-methyladenine (1-meA), and 6-meA, was found in prostate cancer as an important prognostic factor. Additionally, 1-meA has been associated with other cancers.
Miyuki Mabuchi +2 more
semanticscholar +1 more source
Prostate cancer antigen-1/ALKBH3, a DNA/RNA demethylase of 3-methylcytosine, 1-methyladenine (1-meA), and 6-meA, was found in prostate cancer as an important prognostic factor. Additionally, 1-meA has been associated with other cancers.
Miyuki Mabuchi +2 more
semanticscholar +1 more source
Activation and Regulation of the ALKBH3-ASCC Alkylation Repair Pathway
2019DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions. These lesions are sensed by distinct pathways to recruit repair factors specific to type of damage. In particular, the ALKBH family of proteins recognizes and repairs specific alkylated lesions, including 1-methyladenine (m1A) and 3-methylcytosine ...
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ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid-β Pathology.
Advancement of scienceAmyloid-beta (Aβ) aggregation, mitochondrial dysfunction, and cognitive decline are hallmarks of Alzheimer's disease (AD), but its initiating molecular events remain unknown.
Yue-yang Li +25 more
semanticscholar +1 more source
Biochemical and Biophysical Research Communications, 2017
Human AlkB homolog 3 (ALKBH3) is overexpressed in non-small cell lung cancers (NSCLC) and its high expression is significantly correlated with poor prognosis. While ALKBH3 knockdown induces apoptosis in NSCLC cells, the underlying anti-apoptotic mechanisms of ALKBH3 in NSCLC cells remain unclear.
Takahiro Kogaki +8 more
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Human AlkB homolog 3 (ALKBH3) is overexpressed in non-small cell lung cancers (NSCLC) and its high expression is significantly correlated with poor prognosis. While ALKBH3 knockdown induces apoptosis in NSCLC cells, the underlying anti-apoptotic mechanisms of ALKBH3 in NSCLC cells remain unclear.
Takahiro Kogaki +8 more
openaire +2 more sources
The Epigenetic Silencing of ALKBH3 and the Epitranscriptomic Regulation of DNA Repair
2019The DNA damage response is crucial to maintaining the integrity of DNA and the health of a cell. Unrepaired lesions within the DNA can lead to genomic instability and potentially aid in the formation of diseases such as cancer. Some cancers possess dysfunctional DNA repair and chemotherapeutic treatments may aim to exploit this weakness that ...
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