Results 141 to 150 of about 2,197 (160)

Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3

Bioorganic and Medicinal Chemistry, 2018
The mammalian AlkB homologue-3 (AlkBH3) is a member of the dioxygenase family of enzymes that in humans is involved in DNA dealkylation repair. Because of its role in promoting tumor cell proliferation and metastasis of cancer, extensive efforts are ...
Richa Nigam, Topi Ghosh, Subha N Rath
exaly   +5 more sources

The Molecular Basis of Human ALKBH3 Mediated RNA N1-methyladenosine (m1A) Demethylation.

Angewandte Chemie, 2023
N1-methyladenosine (m1A) is a prevalent post-transcriptional RNA modification, and the distribution and dynamics of the modification play key epitranscriptomic roles in cell development.
Lin Zhang, Hong-Chao Duan, Marcin Paduch, Jin-Jia Hu, Chi Zhang, Yajuan Mu, Houwen Lin, Chuan He, A. Kossiakoff, G. Jia, Liang Zhang   +10 more
semanticscholar   +3 more sources

Abstract 4034: ALKBH3 deficiency and liability to alkylating agents in CRC models

Cancer Research, 2022
Colorectal cancer (CRC) is the third most frequent malignancy and the second leading cause of cancer death worldwide. Despite the increase in therapeutic options for the treatment of metastatic CRC (mCRC), cytotoxic chemotherapy using fluoropyrimidines,
P. Vitiello, Elisa Mariella, Pietro Andrei, V. Amodio, G. Germano, Annalisa Lorenzato, Carlotta Cancelliere, A. Bardelli   +7 more
semanticscholar   +2 more sources

Demethylation of m1A assisted degradation of the signal probe for rapid electrochemical detection of ALKBH3 activity with practical applications.

Talanta, 2021
ALKBH3 is an important marker for early diagnosis and histopathological grading of prostate cancer. However, the lack of a rapid and sensitive method to quantify the enzyme's activity in the current time necessitates the development of a new quantitative
Wenting Cheng, Jiehua Ma, Qinfang Tao, Khan Adeel, Liangliang Xiang, Duxian Liu, Zhaoli Zhang, Jinlong Li   +7 more
semanticscholar   +3 more sources

Demethylation-Driven ligase chain reaction for simultaneously sensitive detection of m6A demethylase FTO and m1A demethylase ALKBH3 in breast cancer at Single-Molecule level

Chemical Engineering Journal, 2023
Chun-Yang Zhang
exaly   +2 more sources

Sensitive Measurement of ALKBH3 Activity using a Dual DNA Amplifier by Coupling DNA Circuits with CRISPR/Cas12a

ChemistrySelect, 2023
Abstract DNA repair enzyme ALKBH3 has shown great potential as diagnostic as well as therapeutic target for several cancers. However, methods for the sensitive measurement of ALKBH3 repair activity are highly desirable but challenging.
Fan Lv, Rong Wang, Qiang Xi, Yanli Liu, Zhenkun Wu, Ying Long   +5 more
semanticscholar   +2 more sources

DNA Unwinding by ASCC3 Helicase Is Coupled to ALKBH3-Dependent DNA Alkylation Repair and Cancer Cell Proliferation [PDF]

Molecular Cell, 2011
Demethylation by the AlkB dioxygenases represents an important mechanism for repair of N-alkylated nucleotides. However, little is known about their functions in mammalian cells. We report the purification of the ALKBH3 complex and demonstrate its association with the activating signal cointegrator complex (ASCC).
Nima Mosammaparast, Feizhen Wu, Yang Shi
exaly   +4 more sources

PCA-1/ALKBH3 Contributes to Pancreatic Cancer by Supporting Apoptotic Resistance and Angiogenesis

Cancer Research, 2012
AbstractThe PCA-1/ALKBH3 gene implicated in DNA repair is expressed in several human malignancies but its precise contributions to cancer remain mainly unknown. In this study, we have determined its functions and clinical importance in pancreatic cancer.
Masayuki Sho, Keiji Shimada, Satoshi Yasuda   +2 more
exaly   +3 more sources

Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma

Oncology Reports, 2015
Prostate cancer antigen-1 (PCA-1)/ALKBH3 has been recently identified in human prostate cancer and its expression is correlated with disease progression and prognosis. However, the precise role and function of PCA-1/ALKBH3 in human malignancies are largely unknown.
Masayuki Sho, Kiyohide Fujimoto, Keiji Shimada   +2 more
exaly   +4 more sources

ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer [PDF]

British Journal of Cancer, 2011
We have demonstrated for the first time that a novel human AlkB homologue, ALKBH3, contributes to prostate cancer development, but its clinical and biological roles in lung cancer remain unclear.Expression of both mRNA and protein of PCA-1 was examined by RT-PCR and western blotting.
Tasaki, M, Shimada, K, Kimura, H, Tsujikawa, K, Konishi, N   +4 more
exaly   +3 more sources