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The functional role of m6A demethylase ALKBH5 in cardiomyocyte hypertrophy

Cell Death and Disease
Cardiomyocyte hypertrophy is a major outcome of pathological cardiac hypertrophy. The m6A demethylase ALKBH5 is reported to be associated with cardiovascular diseases, whereas the functional role of ALKBH5 in cardiomyocyte hypertrophy remains confused ...
Chen Meng +8 more
doaj +1 more source

ALKBH5-Mediated ITGB1 m6A Modification in Ovarian Cancer Progression and Immune Evasion

npj Precision Oncology
Ovarian cancer (OC) is the deadliest gynecologic malignancy, with immune evasion contributing to its poor prognosis. This study reveals that the m6A demethylase ALKBH5 enhances OC progression and immune escape by regulating ITGB1 expression.
Zheng He +4 more
doaj +1 more source

Molecular mechanism of ALKBH5‐mediated m6A demethylation regulating lipopolysaccharide‐induced epithelial–mesenchymal transition in sepsis‐induced acute kidney injury

Kaohsiung Journal of Medical Sciences
This study explored the mechanism by which the m6A demethylase ALKBH5 mediates epithelial–mesenchymal transition (EMT) in sepsis‐associated acute kidney injury (SA‐AKI) and AKI‐chronic kidney disease (CKD) transition.
Hai‐Hong Zhao +5 more
doaj +1 more source

ALKBH5 modulates macrophages polarization in tumor microenvironment of ovarian cancer

Journal of Ovarian Research
Background Macrophages play an essential role in regulating ovarian cancer immune microenvironment. Studies have shown that m6A methylation could influence immune microenvironment in cancer.
Yuanyuan An, Hua Duan
doaj +1 more source

The role of ALKBH5 in regulating proliferation and invasion in U251 glioblastoma cells