Results 91 to 100 of about 80,529 (226)
Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers
Chemistry – A European Journal, EarlyView.ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda +5 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.A strategy for the Pt/TiO2‐photocatalyzed β‐scission of nonactivated 3° alcohols in the absence of external oxidants and additives was developed. A wide variety of C‐centered radicals were generated and subsequently engaged in C─C bond‐forming reactions.
Shu Sakurai +3 more
wiley +1 more source
Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance
Chemistry – A European Journal, EarlyView.This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini +3 more
wiley +1 more source
Mechanism and Origin of Remote Stereocontrol in the Organocatalytic Enantioselective Formal C(sp2)-H Alkylation Using Nitroalkanes as Alkylating Agents. [PDF]
J Am Chem Soc, 2022 Chandra Mallojjala S +6 more
europepmc +1 more source
Drug Testing and Analysis, EarlyView.New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley +1 more source
Photoactivatable V-Shaped Bifunctional Quinone Methide Precursors as a New Class of Selective G-quadruplex Alkylating Agents. [PDF]
Chemistry, 2022 Lena A +8 more
europepmc +1 more source
Drug Testing and Analysis, EarlyView.The micro‐scale synthesis of the six out of eight possible tetrahydro‐methyltestosterone sulfate metabolites was performed, and the synthesized materials were used as analytical standards. The analysis of post‐administration sample extracts from methyltestosterone excretion studies against these standards provides further experimental proof for their ...
Yiannis S. Angelis +3 more
wiley +1 more source
ABT199/venetoclax potentiates the cytotoxicity of alkylating agents and fludarabine in acute myeloid leukemia cells. [PDF]
Oncotarget, 2022 Valdez BC +5 more
europepmc +1 more source
Comprehensive genomic characterization defines human glioblastoma genes and core pathways. [PDF]
, 2008 Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation.
Cancer Genome Atlas Research Network
core +1 more source
European Journal of Organic Chemistry, EarlyView.Access to nonproteinogenic α,β‐diamino acids from simple feedstock precursors is of great interest to generate medicinal small molecule libraries. We report a regioselective photoinduced C(sp3)–C(sp3) cross‐dehydrogenative coupling (CDC) of N‐arylglycine derivatives with amides.
Krishnakumar Sachidanandan +4 more
wiley +1 more source