Results 91 to 100 of about 86,457 (338)

Electron Transfer-oxy Radical Mechanism for Anti-cancer Agents: 9-anilinoacridines [PDF]

, 1987
A possible mode of action involving electron transfer is advanced for the 9- anilinoacridines. The mechanism entails formation of toxic oxy radicals which destroy the neoplasm.
Ames, James R., Kovacic, Peter, Ryan, Michael D.   +2 more
core   +1 more source

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]

, 2008
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi, Borgnetto, Brown, Cambau, Champoux, Corbett, Corbett, Ferrero, Fisher, Gatto, Higgins, Kawada, L. M. Fisher, M. Dias, M. Palumbo, Marians, Maxam, McCullough, Mizuuchi, Morrison, Pan, Pan, Pan, Pan, Pan, Peden, Pozzi, Richter, Richter, Richter, Shea, X. S. Pan, Yague, Yoshida, Zechiedrich   +34 more
core   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine. [PDF]

, 2016
Children with aggressive neural tumors have poor survival rates and novel therapies are needed. Previous studies have identified nifurtimox and buthionine sulfoximine (BSO) as effective agents in children with neuroblastoma and medulloblastoma.
Du, Michael, Scorsone, Kathleen A, Woodfield, Sarah E, Zage, Peter E, Zhang, Linna   +4 more
core   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Combination of Bifunctional Alkylating Agent and Arsenic Trioxide Synergistically Suppresses the Growth of Drug-Resistant Tumor Cells

Neoplasia: An International Journal for Oncology Research, 2010
Drug resistance is a crucial factor in the failure of cancer chemotherapy. In this study, we explored the effect of combining alkylating agents and arsenic trioxide (ATO) on the suppression of tumor cells with inherited or acquired resistance to ...
Pei-Chih Lee, Rajesh Kakadiya, Tsann-Long Su, Te-Chang Lee   +3 more
doaj   +1 more source

Active Force Dynamics in Red Blood Cells Under Non‐Invasive Optical Tweezers

Advanced Science, EarlyView.
A non‐invasive method combines low‐power optical tweezers with high‐speed microscopy to simultaneously monitor local membrane forces and displacements in single human red blood cells. This dual‐channel approach reveals a mechano‐dynamic signature that correlates the cell's metabolic state with its mechanical activity. This energetic framework serves as
Arnau Dorn, Clara Luque‐Rioja, Macarena Calero, Diego Herráez‐Aguilar, Francisco Monroy, Niccolò Caselli   +5 more
wiley   +1 more source

Unanticipated differences between α- and γ-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates [PDF]

, 2006
Hairpin polyamide–chlorambucil conjugates containing an {alpha}-diaminobutyric acid ({alpha}-DABA) turn moiety are compared to their constitutional isomers containing the well-characterized {gamma}-DABA turn.
Chou, C. James, Dervan, Peter B., Farkas, Michelle E., Gottesfeld, Joel M., Tsai, Sherry M.   +4 more
core   +4 more sources

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. Biomedicines 2019, 7, 69

Biomedicines, 2019
Temozolomide, a DNA methylating drug, is currently being used first-line in glioblastoma therapy. Although the mode of action of this so-called SN1 alkylating agent is well described, including the types of induced DNA damage triggering the DNA damage ...
Bernd Kaina
doaj   +1 more source