Results 101 to 110 of about 86,457 (338)

Bendamustine plus rituximab is an effective first-line treatment in hairy cell leukemia variant: A report of three cases [PDF]

, 2017
Hairy cell leukemia variant (HCLv) is a chronic lymphoproliferative disorder classified as a provisional entity in the 2016 WHO Classification of Lymphoid Tumors.
Berno, Tamara, Bertorelle, Roberta, Facco, Monica, Frezzato, Federica, Imbergamo, Silvia, Piazza, Francesco, Piva, Elisa, Pizzi, Marco, Riva, Marcello, Scomazzon, Edoardo, Semenzato, Gianpietro, Trentin, Livio, Visentin, Andrea   +12 more
core   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

2-(4-(2-Chloroacetamido)-1-methyl-1H-pyrrole-2-carboxamido)ethyl Acetate

Molbank, 2014
The title compound 2-(4-(2-chloroacetamido)-1-methyl-1H-pyrrole-2-carboxamido)ethyl acetate was synthesized. The structure of the compound was fully characterized by 1H-NMR, 13C-NMR and mass spectral analysis.
Naim H. Al-Said
doaj   +1 more source

RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner [PDF]

, 2017
Sensitivity of cancer cells to DNA damaging chemotherapeutics is determined by DNA repair processes. Consequently, cancer cells may upregulate the expression of certain DNA repair genes as a mechanism to promote chemoresistance.
Abbruzzese, Berger, Biasin, Blackshear, Blandino, Bohr, Bohr, Bohr, Bohr, Brosh, Brosh, Brosh, Brosh, Brosh, Brosh, Byrski, Chen, Chinnaiyan, Constantinou, Del Sal, Dianov, Furuichi, Furuichi, Furuichi, Furuichi, Goldberg, Goto, Harris, Helleday, Helleday, Helleday, Hickson, Jacks, Jackson, Kaina, Kaina, Kaina, Kufe, Lamond, Larocque, Lees-Miller, Madhusudan, Maloney, Messeguer, Moreaux, Ohnishi, Okabe, Resnick, Resnick, Roy, Serrano, Sharma, Sharma, Sharma, Sharma, Sharma, Sharma, Sharma, Sharma, Szallasi, Vindigni, Vogelstein, Vogelstein, Vogelstein, von Mering, Vousden, Xie, Yano   +67 more
core   +2 more sources

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Recent advances in photocatalytic hydrogen peroxide production

PhotoMat, EarlyView., 2023
We classify the representative photocatalytic materials for photosynthesis of hydrogen peroxide (H2O2) in recent years and discuss the related modification methods in detail, providing inspiration and insights for the future design of photocatalysts for H2O2 production.
Jinyu Yan, Yuan Li, Yunxiang Li, Shuxin Ouyang, Tierui Zhang   +4 more
wiley   +1 more source

Dual Chemical Looping/Catalytic Process for Alkylation of Benzene With Ethane and Propane Yielding Ethylbenzene and Cumene Over Copper‐Containing Mordenite

Angewandte Chemie, EarlyView.
We report a dual chemical looping/catalytic process coupling alkane dehydrogenation with aromatic alkylation over Cu‐mordenite, yielding up to 25% alkylated aromatics with >95% selectivity per cycle. In situ NMR, FTIR spectroscopy, and DFT show alkylation proceeds via a π‐bound Cu(I)–olefin intermediate and Brønsted acid sites.
Florent J. Dubray, Yu‐Hsun Wang, Mikalai A. Artsiusheuski, Jiawei Guo, Rene Verel, Ambarish Kulkarni, Jeroen A. van Bokhoven, Vitaly L. Sushkevich   +7 more
wiley   +2 more sources

PURINE ALKYLATING AGENTS 2 , 6-DIAMINO-8-HALO ALKYL PURINES (POTENTIAL ANTI - MALARIALS) [PDF]

Journal of Sciences, Islamic Republic of Iran, 1992
Haloalkyl purines i.e. 2,6-diamino-8-(chloromethyl) purine 10; 2, 6-diamino-X- (chloromethyl) purine 17; 2,6-diamino-8-(chloropropylp) urine 18; were synthesized by two distinct but facile methods.
doaj  

O6-methylguanine-DNA methyltransferase (MGMT) Promoter methylation is a rare event in soft tissue sarcoma

Radiation Oncology, 2012
Background Gene silencing of O6-methylguanine–DNA methyltransferase (MGMT) by promoter methylation improves the outcome of glioblastoma patients after combined therapy of alkylating chemotherapeutic agents and radiation.
Jakob Jens, Hille Maren, Sauer Christian, Ströbel Philipp, Wenz Frederik, Hohenberger Peter   +5 more
doaj   +1 more source

Carcinogenicity of Alkylating Agents [PDF]

Public Health Reports (1896-1970), 1966
T O A CHEMIST interested in carcinogenesis, one of its fascinating aspects is the great variety of chemicals that after being administered to a test animal can lead to cancer. Some very simple molecules, that is, carbon tetrachloride or diazomethane, are carcinogenic in certain species of animals while in others only complex structures are cancer ...
openaire   +2 more sources