Results 101 to 110 of about 3,196,403 (286)

A Comparison of Several Modern Alkylating Agents

open access: yes, 2009
This review covers the application, mechanisms and limitations of simple alkylating agents that can be used for the conversion of carboxylic acids to esters, phenols to aryl ethers, enols to enol ethers and thiols to thioethers.
Guy Lamoureux, C. Agüero
semanticscholar   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Unlocking regioselective meta-alkylation with epoxides and oxetanes via dynamic kinetic catalyst control

open access: yesNature Communications
Regioselective arene C−H bond alkylation is a powerful tool in synthetic chemistry, yet subject to many challenges. Herein, we report the meta-C−H bond alkylation of aromatics bearing N-directing groups using (hetero)aromatic epoxides as alkylating ...
Peng-Bo Bai   +3 more
doaj   +1 more source

Expanding the Inositol Pyrophosphate Toolbox: Stereoselective Synthesis and Application of PP‐InsP4 Isomers in Plant Signaling

open access: yesAngewandte Chemie International Edition, EarlyView.
Stereochemically defined inositol pyrophosphate isomers (PP‐InsP4) were synthesized and assigned by NMR spectroscopy using a chiral solvating agent. In the form of isotopically labeled standards, they were applied in CE‐MS‐based profiling of plant extracts and kinase assays, enabling structural reassignment and functional insight into enzymatic ...
Kevin Ritter   +6 more
wiley   +1 more source

Therapeutic advances of rituximab alone or plus other drugs for membranous nephropathy

open access: yesLinchuang shenzangbing zazhi
Membranous nephropathy (MN) is a common pathological type of adult nephrotic syndrome. According to the etiology, MN is divided into idiopathic membranous nephropathy (IMN) and secondary membranous nephropathy (SMN).
Chao Zhang, Hui Liao, Rong-shan Li
doaj   +1 more source

Clinical evaluation of a new alkylating agent: Cytoxan (cyclophosphamide) [PDF]

open access: bronze, 1960
Peter R. Coggins   +2 more
openalex   +1 more source

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