Results 101 to 110 of about 3,238,601 (165)

Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. Biomedicines 2019, 7, 69. [PDF]

Biomedicines, 2019
Kaina B.
europepmc   +1 more source

Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents. [PDF]

Clin Epigenetics, 2019
Ricci R, Martini M, Ravegnini G, Cenci T, Milione M, Lanza P, Pierconti F, Santini D, Angelini S, Biondi A, Rosa F, Alfieri S, Clemente G, Persiani R, Cassano A, Pantaleo MA, Larocca LM.   +16 more
europepmc   +1 more source

Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes. [PDF]

PLoS Biol, 2017
Tran TQ, Ishak Gabra MB, Lowman XH, Yang Y, Reid MA, Pan M, O'Connor TR, Kong M.   +7 more
europepmc   +1 more source

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Alkylating Agents, the Road Less Traversed, Changing Anticancer Therapy.

Anti-Cancer Agents in Medicinal Chemistry, 2021
Cancer is considered one of the gruelling challenges and poses a grave health hazard across the globe. According to the International Agency for Research on Cancer (IARC), new cancer diagnoses increased to 18.1 million in 2018, with 9.6 million deaths ...
Dipanjan Karati, K. Mahadik, P. Trivedi, Dileep Kumar   +3 more
semanticscholar   +1 more source

Nitrogen Mustards as Alkylating Agents: A Review on Chemistry, Mechanism of Action and Current USFDA Status of Drugs.

Anti-Cancer Agents in Medicinal Chemistry, 2019
Background& Objective: Nitrogen mustard derivatives form one of the major class of the anti-cancer agents according to the USFDA approved drugs. These are polyfunctional alkylating agents which are distinguished by a unique mechanism of adduct formation ...
G. More, Asha B. Thomas, S. Chitlange, R. Nanda, Rahul Gajbhiye   +4 more
semanticscholar   +1 more source

Thioimidazolium Ionic Liquids as Tunable Alkylating Agents.

Journal of Organic Chemistry, 2018
Alkylating ionic liquids based on the thioimidazolium structure combine the conventional properties of ionic liquids, including low melting point and nonvolatility, with the alkylating function. Alkyl transfer occurs exclusively from the S-alkyl position,
R. Guterman, Han Miao, M. Antonietti
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Alkylsilyl Peroxides as Alkylating Agents in the Copper-Catalyzed Selective Mono-N-Alkylation of Primary Amides and Arylamines.

Chemistry, 2017
The copper-catalyzed selective mono-N-alkylation of primary amides or arylamines using alkylsilyl peroxides as alkylating agents is reported. The reaction proceeds under mild reaction conditions and exhibits a broad substrate scope with respect to the ...
Ryu Sakamoto, S. Sakurai, K. Maruoka
semanticscholar   +1 more source

Cu(I)-Catalyzed Enantioselective Friedel-Crafts Alkylation of Indoles with 2-Aryl-N-sulfonylaziridines as Alkylating Agents.

Organic Letters, 2016
A highly enantioselective Friedel-Crafts alkylation of indoles with N-sulfonylaziridines as alkylating agents has been developed by utilizing the complex of Cu(CH3CN)4BF4/(S)-Segphos as a catalyst.
Chen Ge, Ren-Rong Liu, Jian-rong Gao, Yi‐Xia Jia   +3 more
semanticscholar   +1 more source