Results 221 to 230 of about 3,196,403 (286)

Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Autophagy is essential for cellular homeostasis, and its impairment contributes to cardiac hypertrophy. Modulating autophagy has shown potential in treating pathological hypertrophy. Prolylcarboxypeptidase (PRCP), a lysosomal enzyme that hydrolyzes angiotensin II to Ang1‐7, has an unclear role in cardiac autophagy and hypertrophy.
Fangchao Zhou, Jun Xia, Yingjuan Liu, Wenqi He, Hongyuan Zhang, Bernard D. Keavney, Min Zi, Binh Y. Nguyen, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Susanne S. Hille, Elizabeth J. Cartwright, Oliver J. Müller, Honglin Xu, Sam Butterworth, Xin Wang   +16 more
wiley   +1 more source

Comprehensive analysis of extracellular matrix remodelling via cyclophilin inhibition in human models of alcohol‐related liver fibrosis

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic liver disease and hepatic fibrosis constitute a threat to global health. Clinical translation of preclinical research has been limited, highlighting an urgent need for novel treatments. Cyclophilin inhibitors have shown beneficial effects in liver disease; however, the underlying mechanism of action and the effect across ...
Una Rastovic, Sara Campinoti, Lai Wei, Bruna Almeida, Sergio Francesco Bozzano, Ramin Amiri, Nicola Harris, Omolola Ajayi, Tsin Shue Koay, Caoimhe Kerins, Fiona N. Kenny, Ane Zamalloa, Lissette Adofina, Rosa Miquel, Yoh Zen, Parthi Srinivasan, Krishna Menon, Nigel Heaton, Camilla Luni, Eileen Gentleman, Tanya Shaw, Daren Ure, Shilpa Chokshi, Luca Urbani, Elena Palma   +24 more
wiley   +1 more source

RBM39 Promotes Base Excision Repair to Facilitate the Progression of HCC by Stabilising OGG1 mRNA

Cell Proliferation, EarlyView.
Targeting RBM39 attenuates BER via destabilising OGG1 mRNA and potentiates KBrO3‐induced oxidative stress in HCC. Our study represents a valuable treatment strategy combining indisulam and an oxidative stress inducer in HCC. ABSTRACT Targeting base excision repair (BER) has been an attractive strategy in cancer therapeutics.
Hongda An, Anliang Xia, Siyuan Liu, Dongjun Luo, Longpo Geng, Binghua Li, Beicheng Sun, Zhu Xu   +7 more
wiley   +1 more source

Lead Astray? The Hidden Contaminants in Australian Anabolic–Androgenic Steroid Market and Their Potential Health Impact

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction Unregulated anabolic–androgenic steroid (AAS) markets are a global phenomenon with significant variability in product composition and purity. This study aimed to determine the chemical composition of AAS sold in Australia. Methods This study analysed anonymously donated AAS samples.
Alison Craven, Jason Ferris, Suzanne Nielsen, Timothy Piatkowski   +3 more
wiley   +1 more source

Cyclophosphamide—A promising solution for refractory ICANS

British Journal of Haematology, EarlyView.
Manan Vora, Himanshu Gujarathi, Hasmukh Jain, Alok Shetty, Vasundhara Patil, Savan Pandey, M. V. Ramya Kumar, Lingaraj Nayak   +7 more
wiley   +1 more source

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Alkylating Agents, the Road Less Traversed, Changing Anticancer Therapy.

Anti-Cancer Agents in Medicinal Chemistry, 2021
Cancer is considered one of the gruelling challenges and poses a grave health hazard across the globe. According to the International Agency for Research on Cancer (IARC), new cancer diagnoses increased to 18.1 million in 2018, with 9.6 million deaths ...
Dipanjan Karati, K. Mahadik, P. Trivedi, Dileep Kumar   +3 more
semanticscholar   +1 more source

ChemInform Abstract: ORGANOBORANES AS ALKYLATING AGENTS [PDF]

Chemischer Informationsdienst, 1976
AbstractDurch Umsetzung von 1‐Hexen (I) mit Boran‐Dimethylsulfid in Äther wird Trihexylboran (II) erhalten, das mit Methylvinylketon (III) in einer Radikalkettenreaktion in 8l%iger Gesamtausbeute zu 2‐Decanon (IV) reagiert.
Gary W. Neal, John D. Baker, George W. Kabalka   +2 more
openaire   +2 more sources

Nitrogen Mustards as Alkylating Agents: A Review on Chemistry, Mechanism of Action and Current USFDA Status of Drugs.

Anti-Cancer Agents in Medicinal Chemistry, 2019
Background& Objective: Nitrogen mustard derivatives form one of the major class of the anti-cancer agents according to the USFDA approved drugs. These are polyfunctional alkylating agents which are distinguished by a unique mechanism of adduct formation ...
G. More, Asha B. Thomas, S. Chitlange, R. Nanda, Rahul Gajbhiye   +4 more
semanticscholar   +1 more source

Alkylating Agents in Bronchogenic Carcinoma

Journal of Occupational and Environmental Medicine, 1969
Abstract A large number of patients in a group of Veterans Administration Hospitals received a variety of alkylating agents in studies in which these agents were randomized with an inert compound. Intravenous cyclophosphamide, and possibly nitrogen mustard, had a slight favorable influence upon survival for all patients.
Edward Humphrey, Henry P. Close, Robert A. Green, Mary Ellen Patno   +3 more
openaire   +4 more sources

Thioimidazolium Ionic Liquids as Tunable Alkylating Agents.

Journal of Organic Chemistry, 2018
Alkylating ionic liquids based on the thioimidazolium structure combine the conventional properties of ionic liquids, including low melting point and nonvolatility, with the alkylating function. Alkyl transfer occurs exclusively from the S-alkyl position,
R. Guterman, Han Miao, M. Antonietti
semanticscholar   +1 more source