Results 231 to 240 of about 3,196,403 (286)
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Chemistry, 2017
The copper-catalyzed selective mono-N-alkylation of primary amides or arylamines using alkylsilyl peroxides as alkylating agents is reported. The reaction proceeds under mild reaction conditions and exhibits a broad substrate scope with respect to the ...
Ryu Sakamoto, S. Sakurai, K. Maruoka
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The copper-catalyzed selective mono-N-alkylation of primary amides or arylamines using alkylsilyl peroxides as alkylating agents is reported. The reaction proceeds under mild reaction conditions and exhibits a broad substrate scope with respect to the ...
Ryu Sakamoto, S. Sakurai, K. Maruoka
semanticscholar +1 more source
Alkylating agents for Waldenstrom's macroglobulinaemia
Cochrane Database of Systematic Reviews, 2009Waldenstrom's macroglobulinaemia (WM) is an uncommon B-cell lymphoproliferative disorder characterized by bone marrow infiltration and production of monoclonal immunoglobulin. Uncertainty remains if alkylating agents, such as chlorambucil, melphalan or cyclophosphamide, are an effective form of management.To assess the effects and safety of the ...
Taixiang Wu, Jianlong Tan, Kun Yang
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1989
The phenotypic expression of intrinsic or natural resistance and the selection of acquired resistance through sublethal exposure to anticancer agents remain major obstacles to the successful treatment of human neoplasms. A large number of solid tumors that fail to respond to chemotherapy do so because they possess characteristics that allow them to ...
Kenneth D. Tew, Margie L. Clapper
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The phenotypic expression of intrinsic or natural resistance and the selection of acquired resistance through sublethal exposure to anticancer agents remain major obstacles to the successful treatment of human neoplasms. A large number of solid tumors that fail to respond to chemotherapy do so because they possess characteristics that allow them to ...
Kenneth D. Tew, Margie L. Clapper
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Organic Letters, 2016
A highly enantioselective Friedel-Crafts alkylation of indoles with N-sulfonylaziridines as alkylating agents has been developed by utilizing the complex of Cu(CH3CN)4BF4/(S)-Segphos as a catalyst.
Chen Ge +3 more
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A highly enantioselective Friedel-Crafts alkylation of indoles with N-sulfonylaziridines as alkylating agents has been developed by utilizing the complex of Cu(CH3CN)4BF4/(S)-Segphos as a catalyst.
Chen Ge +3 more
semanticscholar +1 more source
Bulletin du cancer, 2011
With the approval of mechlorethamine by the FDA in 1949 for the treatment of hematologic malignancies, alkylating agents are the oldest class of anticancer agents. Even though their clinical use is far beyond the use of new targeted therapies, they still occupy a major place in specific indications and sometimes represent the unique option for the ...
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With the approval of mechlorethamine by the FDA in 1949 for the treatment of hematologic malignancies, alkylating agents are the oldest class of anticancer agents. Even though their clinical use is far beyond the use of new targeted therapies, they still occupy a major place in specific indications and sometimes represent the unique option for the ...
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2008
Chapter 5 deals with antitumor alkylating agents and platinum complexes. We first explain how the selectivity of DNA alkylation is governed by steric effects and, especially, by the “soft” or “hard” electrophilic character of the alkylating species, following by a comment about the several types of effects that different alkylating agents induce on DNA
Carmen Avendaño, J. Carlos Menéndez
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Chapter 5 deals with antitumor alkylating agents and platinum complexes. We first explain how the selectivity of DNA alkylation is governed by steric effects and, especially, by the “soft” or “hard” electrophilic character of the alkylating species, following by a comment about the several types of effects that different alkylating agents induce on DNA
Carmen Avendaño, J. Carlos Menéndez
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The Impact of Commonly Used Alkylating Agents on Artifactual Peptide Modification.
Journal of Proteome Research, 2017Iodoacetamide is by far the most commonly used agent for alkylation of cysteine during sample preparation for proteomics. An alternative, 2-chloroacetamide, has recently been suggested to reduce the alkylation of residues other than cysteine, such as the
P. Hains, P. Robinson
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JAMA: The Journal of the American Medical Association, 1971
Eleven patients with malignant lymphoma had sperm counts done in the course of maintenance treatment with the alkylating agents chlorambucil or cyclophosphamide. Of the nine patients treated with chlorambucil, all had aspermia after treatment with doses ranging from 10.1 to 17.7 mg/kg of body weight.
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Eleven patients with malignant lymphoma had sperm counts done in the course of maintenance treatment with the alkylating agents chlorambucil or cyclophosphamide. Of the nine patients treated with chlorambucil, all had aspermia after treatment with doses ranging from 10.1 to 17.7 mg/kg of body weight.
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On the Biological Alkylating Agents
Perspectives in Biology and Medicine, 1973Les poisons peuvent etre employes comme agents de destruction de la vie ou comme moyens de guerison des maladies; mais, outre ces deux usages bien connus de tout le monde, il en est un troisieme qui interesse particulierement le physiologiste. Pour lui, le poison devient un instrument qui dissocie et analyse les phenomenes les plus delicats de la ...
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Synthesis and Performance of a Biomimetic Indicator for Alkylating Agents.
Journal of Organic Chemistry, 20154-(4-Nitrobenzyl)pyridine (NBP) is a colorimetric indicator compound for many types of carcinogenic alkylating agents. Because of the similar reactivity of NBP and guanine in DNA, NBP serves as a DNA model.
Philip A Provencher, J. Love
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