DNA Damaging Agents in Chemical Biology and Cancer
CHIMIA, 2020 Despite their toxicity, DNA alkylating drugs remain a cornerstone of anticancer therapy. The classical thinking was that rapidly dividing tumour cells left more of its DNA in an exposed single-stranded state, making these rapidly dividing cells more ...
Basilius Sauter, Dennis Gillingham
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Dinuclear platinum(II) sulfide–thiolate complexes [Pt₂(μ-S)(μ-SR)(PPh₃)₄]⁺ containing fluorinated substituents and the identification of a SC₆F₅ π interaction in the crystal structure of [Pt₂(μ-S)(μ-SCH₂C₆F₅)(PPh₃)₄]BPh₄•2C₆H₆ [PDF]
, 2011 Reactions of the platinum(II) sulfido complex [Pt₂(μ-S)₂(PPh₃)₄] with the alkyl iodides ICH₂CH₂(CF₂)nCF₃ (n = 3, 7) gives good yields of the monoalkylated products [Pt₂(μ-S){μ-SCH₂CH₂(CF₂)nCF₃}(PPh₃)₄]⁺, which were isolated as PF₆⁺or BPH₄⁻ salts, and ...
Henderson, William +2 more
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The Genetic Basis of Mutation Rate Variation in Yeast. [PDF]
, 2018 Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis ...
Bloom, Joshua S +2 more
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Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]
, 2006 Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
A Balmain +57 more
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Journal of Saudi Chemical Society, 2017 The combination of two pharmacological entities in a single compound has been utilized as a promising drug design strategy for site-specificity. So two nitrogen mustard agents were synthesized by conjugating mustard with the benzodiazepine nucleus in the
Rajesh K. Singh +2 more
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The potential role and application of PARP inhibitors in cancer treatment [PDF]
, 2009 Background: Since many anti-cancer agents act by inflicting DNA damage on tumour cells, there is increasing interest in the use of inhibitors of DNA repair to increase the cytotoxicity of these agents.
Chalmers, Anthony J
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Molecules, 2021 Specific RNA sequences regulate functions essential to life. The Trans-Activation Response element (TAR) is an RNA stem–bulge–loop structure involved in several steps of HIV-1 replication.
Alice Sosic +5 more
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A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers. [PDF]
, 2019 Cohesin is a multiprotein ring that is responsible for cohesion of sister chromatids and formation of DNA loops to regulate gene expression. Genomic analyses have identified that the cohesin subunit STAG2 is frequently inactivated by mutations in cancer.
Ashworth, Alan +4 more
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Revista Brasileira de Hematologia e Hemoterapia, 2005 A leucemia linfóide crônica (LLC-B) é uma neoplasia de comportamento indolente, que o tratamento imediato não mostrou vantagem em prolongar a sobrevida dos pacientes em estádios iniciais.
Carlos S. Chiattone
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Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time [PDF]
, 2003 DNA single strand breaks (SSBs) are one of the most frequent DNA lesions in genomic DNA generated either by oxidative stress or during the base excision repair pathways.
Asakura, Shoji +5 more
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