Results 41 to 50 of about 3,238,601 (165)

Ion Specificity and Micellization of Ionic Surfactants: A Monte Carlo Study [PDF]

, 2014
We develop a simulation method which allows us to calculate the critical micelle concentrations for ionic surfactants in the presence of different salts. The results are in good agreement with the experimental data. The simulations are performed on a simple cubic lattice.
arxiv   +1 more source

Atomistic simulation of structure and dynamics of columnar phases of hexabenzocoronene derivatives [PDF]

, 2006
Using atomistic molecular dynamics simulations we study solid and liquid crystalline columnar discotic phases formed by alkyl-substituted hexabenzocoronene mesogens. Correlations between the molecular structure, packing, and dynamical properties of these materials are established.
arxiv   +1 more source

ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.

Cancer Discovery, 2014
UNLABELLED Alkylating agents are a first-line therapy for the treatment of several aggressive cancers, including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy.
S. Agnihotri, K. Burrell, P. Buczkowicz, M. Remke, B. Golbourn, Yevgen Chornenkyy, Aaron S. Gajadhar, Nestor A. Fernandez, I. Clarke, M. Barszczyk, S. Pajovic, Christian Ternamian, R. Head, N. Sabha, R. Sobol, Michael D. Taylor, J. Rutka, Chris Jones, P. Dirks, G. Zadeh, C. Hawkins   +20 more
semanticscholar   +1 more source

EPR Study of Radicals in Irradiated Ionic Liquids and Implications for the Radiation Stability of Ionic Liquid-Based Extraction Systems [PDF]

arXiv, 2007
The radiation- and photo- chemistry of room temperature ionic liquids (ILs) composed of ammonium, phosphonium, pyrrolidinium, and imidazolium cations and bis(triflyl)amide, dicyanamide, and bis(oxalato)borate anions, have been studied using low-temperature Electron Paramagnetic Resonance (EPR).
arxiv  

A Novel Acetylation Cycle of Transcription Co-activator Yes-associated Protein That Is Downstream of Hippo Pathway Is Triggered in Response to SN2 Alkylating Agents*

Journal of Biological Chemistry, 2012
Background: YAP is a target molecule of the Hippo pathway. Results: YAP acetylation and deacetylation were mediated by CBP/p300 acetyltransferase and SIRT1 deacetylase, respectively. Conclusion: A YAP acetylation/deacetylation cycle is located downstream
S. Hata, J. Hirayama, H. Kajiho, K. Nakagawa, Y. Hata, T. Katada, M. Furutani-Seiki, H. Nishina   +7 more
semanticscholar   +1 more source

The scarlet letter of alkylation: a mini review of selective alkylating agents.

Translational Oncology, 2012
If there were a stigma scale for chemotherapy, alkylating agents would be ranked at the top of the list. The chemical term alkylation is associated with nonselective toxicity, an association that dates back to the use of nitrogen mustards during World ...
B. Oronsky, T. Reid, S. Knox, J. Scicinski   +3 more
semanticscholar   +1 more source

Effect of ion structure on the physicochemical properties and gas absorption of surface active ionic liquids [PDF]

Physical Chemistry Chemical Physics, 2023, 25, 6808-6816
Surface active ionic liquids (SAILs) combine useful characteristics of both ionic liquids (ILs) and surfactants, hence are promising candidates for a wide range of applications. However, the effect of SAIL ionic structures on their physicochemical properties remains unclear, which limits their uptake.
arxiv   +1 more source

High-resolution IR absorption spectroscopy of polycyclic aromatic hydrocarbons in the 3 micron region: role of hydrogenation and alkylation [PDF]

, 2018
Aims. We aim to elucidate the spectral changes in the 3 micron region that result from chemical changes in the molecular periphery of polycyclic aromatic hydrocarbons (PAHs) with extra hydrogens (H-PAHs) and methyl groups (Me-PAHs). Methods. Advanced laser spectroscopic techniques combined with mass spectrometry were applied on supersonically cooled 1 ...
arxiv   +1 more source

DNA Damage Induced by Alkylating Agents and Repair Pathways

Journal of Nucleic Acids, 2010
The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes, necessitating a clear understanding of the repair mechanisms. Simple methylating agents form adducts at N- and O-atoms.
N. Kondo, A. Takahashi, K. Ono, T. Ohnishi   +3 more
semanticscholar   +1 more source

Sensitization to Radiation and Alkylating Agents by Inhibitors of Poly(ADP-ribose) Polymerase Is Enhanced in Cells Deficient in DNA Double-Strand Break Repair

Molecular Cancer Therapeutics, 2010
As single agents, chemical inhibitors of poly(ADP-ribose) polymerase (PARP) are nontoxic and have clinical efficacy against BRCA1- and BRCA2-deficient tumors.
Dana A. Löser, A. Shibata, A. Shibata, L. Woodbine, P. Jeggo, A. Chalmers   +5 more
semanticscholar   +1 more source