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The alkylglycerol monooxygenase (AGMO) gene previously involved in autism also causes a novel syndromic form of primary microcephaly in a consanguineous Saudi family [PDF]
Journal of the Neurological Sciences, 2016 Autosomal recessive primary microcephaly (MCPH) refers to a genetically heterogeneous group of neurodevelopmental disorders in which patients exhibit a marked decrease in occipitofrontal head circumference at birth and a variable degree of intellectual ...
Jamal Nasir, Kate Everett, Jun Wang
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Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages
Biochemical and Biophysical Research Communications, 2013Alkylglycerol monooxygenase (AGMO, glyceryl ether monooxygenase) is an enzyme known to catalyze the cleavage of the O-alkyl bond of glyceryl ether lipids. Identification of the gene encoding AGMO was reported recently, however, the involvement of AGMO in modulating cellular lipids has not been reported until now.
Takao Shimizu +2 more
exaly +3 more sources
Stimulation of the microsomal alkylglycerol monooxygenase by catalase
Lipids and Lipid Metabolism, 1976Liver cytosol contains a heat-sensitive nondialyzable soluble factor necessary for maximal activity of the alkylglycerol monooxygenase present in rat liver microsomes. In this report, we demonstrate that the stimulatory component in rat liver supernatant is catalase.
Fred Snyder, V Fitzgerald, R C Baker
exaly +3 more sources
Solubiliztion and Partial Characterization of Alkylglycerol Monooxygenase from the Liver Mkcosomes [PDF]
FEBS Journal, 1983 The enzyme alkylgloycerol monooxygenase wa slubuilized ith 2% of Triton X‐100 and partially pufified approximatelkyt to 83–fold with a 36% yield after a procedure which included 6‐aminohexyl‐Sephaorse and DEAE cellulose column chromatography, followed by a surcros edensity gradient centrifugation.
Teruo Ishibashi, Yoh Imai
exaly +3 more sources
Phospholipid requirement of alkylglycerol monooxygenase from rat liver microsomes
Lipids, 1986AbstractThe alkylglycerol monooxygenase catalyzing the cleavage of the ether bond in alkylglycerol resides in rat liver microsomes. The enzyme preparation was freed of phospholipids by sodium deoxycholate treatment followed by gel filtration in the presence of deoxycholate. The removal of phospholipids markedly decreased the alkylglycerol monooxygenase
Kuniaki Seyama, Teruo Ishibashi
exaly +3 more sources
A continuous assay forO‐alkylglycerol monooxygenase (E.C. 1.14.16.5)
Lipids, 1987AbstractThe antitumor activity of alkyl lysophospholipids has raised some questions concerning the degradation ofO‐alkyl bonds in naturally occurring ether lipids. In this report, we describe the first continuous assay forO‐alkylglycerol monooxygenase (AGMO), the only enzyme known to cleave theO‐alkyl bond in saturated ether lipids and ether ...
Kötting, J., Unger, C., Eibl, H.
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Lipids, 1987
AbstractSynthetic alkyl lysophospholipids (ALP) show antineoplastic activity. In the present discussion, the cytotoxicity of ALP is attributed to their accumulation in tumor cells. Some neoplastic cell species, in contrast to normal cells, cannot metabolize ALP because of a lack ofO‐alkylglycerol monooxygenase (AGMO) activity.
Kötting, J., Unger, C., Eibl, H.
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AbstractSynthetic alkyl lysophospholipids (ALP) show antineoplastic activity. In the present discussion, the cytotoxicity of ALP is attributed to their accumulation in tumor cells. Some neoplastic cell species, in contrast to normal cells, cannot metabolize ALP because of a lack ofO‐alkylglycerol monooxygenase (AGMO) activity.
Kötting, J., Unger, C., Eibl, H.
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[Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1981
The author has investigated the condition for solubilization of alkylglycerol monooxygenase from rat liver microsome. The solubilization of this enzyme has been done by using Triton X-100, because this enzyme is considered to be relatively stable in the presence of 0.5% Triton X-100. It is suggested that there are factors leading to decrement of enzyme
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The author has investigated the condition for solubilization of alkylglycerol monooxygenase from rat liver microsome. The solubilization of this enzyme has been done by using Triton X-100, because this enzyme is considered to be relatively stable in the presence of 0.5% Triton X-100. It is suggested that there are factors leading to decrement of enzyme
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2017
Ikuro Abe, Hitomi Nakamura
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Ikuro Abe, Hitomi Nakamura
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TMEM195 ENCODES FOR TETRAHYDROBIOPTERIN-DEPENDENT ALKYLGLYCEROL MONOOXYGENASE ACTIVITY
2013WERNER ERNST R, WATSCHINGER KATRIN
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