Results 251 to 260 of about 116,077 (356)

Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship

Angewandte Chemie, EarlyView.
Macrocycles are effective molecular glues to stabilize the 14‐3‐3/ChREBP interaction. Linker length modulation uncovered an inverse correlation between the macrocycle binding affinity to 14‐3‐3 and its cooperativity in 14‐3‐3/ChREBP stabilization.
Marloes A. M. Pennings, Merel A. W. van den Bosch, Ansgar Oberheide, Carlo J. A. Verhoef, Christian Ottmann, Albert J. Markvoort, Galen P. Miley, Luc Brunsveld   +7 more
wiley   +1 more source

Base-Regulated Spiroannulation: Insights into the Palladium-Catalyzed [2 + 2 + 1] Annulation of 1,2-Dihaloarenes, Alkynes, and 2‑Naphthol. [PDF]

ACS Omega
Zhong JF, Li JY, Shi YB, Feng XY, Liu G, Duan LF, Hu ZT, Mu WH.   +7 more
europepmc   +1 more source

Photothermal Conversion Promotes Challenging SNAr for Facile C─N Bond Formation

Angewandte Chemie, EarlyView.
Photothermal conversion enables facile aromatic C─N bond formation via red light irradiation. A variety of inter‐ and intramolecular SNAr transformations are achieved under mild, schematically simple conditions. Additionally, a thermally promoted halogen exchange mechanism provides access to aryl bromides, chlorides, and fluorides – making this ...
Megan E. Matter, Rory C. Devin, Erin E. Stache   +2 more
wiley   +1 more source

1,2,3-Triazolo-Bridged Click Coupling of Pinane-Based Azidodiol Enantiomers with Pyrimidine- and Purine-Based Building Blocks: Synthesis, Antiproliferative, and Antimicrobial Evaluation. [PDF]

Int J Mol Sci
Depp D, Tari K, Szekeres A, Kovács A, Zupkó I, Szakonyi Z.   +5 more
europepmc   +1 more source

Non‐Statistical Assembly of Donor–Acceptor Cages for Light‐Induced Charge Separation

Angewandte Chemie, EarlyView.
Donor–acceptor functionalized cages [Pd2D2A2]4+ with defined stoichiometry and stereoconfiguration were assembled in a single step by employing the shape complementary assembly (SCA) strategy. While the redox functionalities remain largely independent in the ground state, photoexcitation results in ultrafast ligand‐to‐ligand charge transfer, as ...
Jacopo Tessarolo, Laura Neukirch, Kai Wu, Jan‐Hendrik Borter, Haeri Lee, Dirk Schwarzer, Guido H. Clever   +6 more
wiley   +1 more source

Ketone Oximes as NO₂ Radical Precursors for Regioselective Iodo-Nitrosylative Cyclization of Unactivated 1,6-Enynes. [PDF]

J Org Chem
Mutra MR, Chandana TL, Chu YS, Li CH, Wang JJ.   +4 more
europepmc   +1 more source

A Crystalline Mono‐Coordinate Indium(I)‐Phosphaalkenyl

Angewandte Chemie, EarlyView.
The redox neutral carbometallation of a phospha‐alkyne using the dimeric indium(I) compound (InTer)2 is reported. This reaction affords a mono‐coordinate indium(I) compound that can reversibly extrude the phospha‐alkyne upon addition of a Lewis acid. Abstract The synthesis of the mono‐coordinate indium(I) compound In[C(Ad)═PTer] (Ad = 1‐adamantyl, Ter =
Álvaro García‐Romero, Maren Pink, Israel Fernández, Jose M. Goicoechea   +3 more
wiley   +1 more source

1-deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway. [PDF]

Cell Chem Biol
Tsai YT, Lipp NF, Seidel O, Varma R, Laguerre A, Solorio-Kirpichyan K, Wong AM, Brea RJ, McGregor GH, Cordes T, Devaraj NK, Kuerschner L, Neal S, Metallo CM, Budin I.   +14 more
europepmc   +1 more source

Boosting the Nucleophilicity of the Diphenylphosphide Anion with Crown Ether Supported Heavy Alkali Metals to Facilitate Highly Efficient Catalytic Alkene Isomerisation

Angewandte Chemie, EarlyView.
Here, we report a breakthrough study in catalytic alkene isomerisation using crown ether‐supported alkali metal phosphides in which the activity increases sequentially and significantly as Group One is descended with Cs(18‐crown‐6)PPh2 (1Cs) performing best.
Felix Krämer, Thomas M. Horsley Downie, Robert E. Mulvey   +2 more
wiley   +1 more source

Development of a Spectroscopic Map to Explain the Broad Raman Peak for Alkynes Solvated in Triethylamine. [PDF]

J Phys Chem B
Aneesh A, Streu K, Daly CA.
europepmc   +1 more source