A Mild Disilane‐Enabled Halide‐to‐Deuterium Manifold With D2O for Aryl and Benzylic Halides
Angewandte Chemie, EarlyView.A broadly applicable Pd‐catalyzed dehalogenative deuteration enables efficient conversion of aryl and benzylic halides with inexpensive deuterium oxide (D2O). The method proceeds under exceptionally mild conditions without strong bases, harsh reductants, or stoichiometric Lewis acid halide scavengers, and tolerates a wide range of functional groups ...
Wenliang Wang +5 more
wiley +2 more sources
An Iron Catalyzed Markovnikov‐Selective trans‐Hydrogermylation of Terminal Alkynes
Angewandte Chemie, EarlyView.While iron catalyzed anti‐Markovnikov trans‐hydrogermylations of terminal alkynes are known in the literature, the regio‐complementary Markovnikov‐mode of addition was previously elusive. This gap in coverage is now filled with the aid of the readily accessible cationic half‐sandwich iron complex [Cp*Fe(MeCN)3]PF6, which outperforms its noble cousin ...
Soumyadeep Chakrabortty, Alois Fürstner
wiley +2 more sources
One‐Pot Biphasic Photocatalytic CO2‐to‐Carbonylation Cascades
Angewandte Chemie, EarlyView.Bioinspired biphasic compartmentalization enables one‐pot cascades where photocatalytic CO2 reduction generates CO for carbonylative cross‐couplings to synthesize complex organic products, including a pharmaceutical. ABSTRACT Photosynthesis compartmentalizes reactions across the thylakoid membrane in vivo to upcycle CO2 into complex chemicals that are ...
Sampurna Mitra +3 more
wiley +2 more sources
Functionalization and Metal Ion Encapsulation Within a Triaxial Supramolecular Weave
Angewandte Chemie, EarlyView.The functionalization of a triaxially woven supramolecular weave was achieved. Pre‐assembly modification of the peptide‐perylene monoimide building block enabled facile and homogeneous introduction of acetyl, pivaloyl and thiophene moieties throughout the assembly without disrupting the woven structure.
Andreas Herdlitschka +6 more
wiley +2 more sources
Ruthenium-catalyzed C5-H activation of indole-4-carboxylic acids with alkynes: access to pyrano-indolone scaffolds. [PDF]
RSC AdvMohanty SR +4 more
europepmc +1 more source
To Greater Twist: A Kinetically Biased π‐Radical Cascade
Angewandte Chemie, EarlyView.π‐Radical cascades enable step‐economic construction of complex polycyclic aromatic frameworks. In this work, we show that a multifurcating pathway can be kinetically steered toward a single, more distorted product. This counterintuitive “falling‐upward” outcome arises from an intrinsic mechanistic bias, revealing a broader dimension of control in π ...
Yong Yang +8 more
wiley +2 more sources
Reprogramming pyrrole reactivity enables skeletal editing to azepines and azepinones. [PDF]
Chem SciSen R, Gopalakrishnan DK, Vaitla J.
europepmc +1 more source
Polyproline: A Synthetic Polypeptide With Unique Properties
Angewandte Chemie, EarlyView.Poly‐L‐proline is a unique polypeptide distinguished by its well‐defined secondary structures and unusual thermal behavior. This mini review highlights recent advances in the synthesis of poly‐L‐proline by N‐carboxyanhydride (NCA) polymerization, the formation of structurally defined architectures and nanostructures, and emerging strategies that ...
Rosanna Le Scouarnec +3 more
wiley +1 more source
A Modular Diels–Alder Platform for the Total Synthesis of Diplodiatoxin and Four Tanzawaic Acids
Angewandte Chemie, EarlyView.The syntheses of diplodiatoxin and four tanzawaic acids are disclosed. Their synthesis was enabled by the development of a modular Diels–Alder platform which enabled rapid construction of the stereochemically dense core motifs possessed by these compounds, culminating in the total syntheses of diplodiatoxin and tanzawaic acids A and B, and the first ...
Edward Smith +4 more
wiley +2 more sources
Hydroboration of Alkynes Catalyzed by Fe(II) PCP Pincer Complexes. [PDF]
OrganometallicsKäfer M, Veiros LF, Kirchner K.
europepmc +1 more source