Results 151 to 160 of about 16,283 (253)

<i>N</i>-Mesyl-Enabled Cu₂O Catalysis: Synthesis of (<i>E</i>)-3-Alkylideneisoindolin-1-ones and 3,4-Unsubstituted Isoquinolones via Sequential Alkynylation/Annulation. [PDF]

J Org Chem
Ali AR, Hu L.
europepmc   +1 more source

Water, Alcohols, Amines, and Amides as Formal Hydrogen‐Atom‐Transfer Reagents Through Activation With Redox‐Active Lewis Acids

Angewandte Chemie, EarlyView.
Protic molecules containing strong O─H or N─H bonds typically resist hydrogen‐atom abstraction because of the high reactivity of the resulting heteroatom‐centered radicals. However, association of the protic molecules with redox‐active Lewis acids can provide powerful hydrogen‐atom donors or proton‐coupled‐electron‐transfer reagents.
Petra Vojáčková, Armido Studer
wiley   +1 more source

From alkynes to spiroindole δ-lactams <i>via</i> a copper-nitrenoid intermediate featuring unusual 1,1-addition and high <i>Z</i>-selectivity. [PDF]

Chem Sci
Ren Z, Feng T, Li Y, Chu M, Zheng Y, Gao T, Han B, Guo R, Ma H, Wang JJ, Zhang Y.   +10 more
europepmc   +1 more source

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +1 more source

Enabling Fluoroalkyl-Sulfonylalkylation and Fluoroalkyl-Halogenation of Alkenes and Alkynes via Photoredox Catalysis. [PDF]

J Am Chem Soc
Hewa Inaththappulige SIN, Acharya A, Agampodi NDDZ, Singh H, Giri R.   +4 more
europepmc   +1 more source

Chemically Regulated STING‐Activating Prodrugs of Deoxyribose Cyclic Dinucleotides Elicit Robust Immune Activation and Durable Antitumor Immunity

Angewandte Chemie, EarlyView.
All three diastereoisomers of an esterase‐sensitive phosphotriester dCDN prodrug demonstrate improved activity. The (Rp,Rp) diastereoisomer shows the highest activity with an EC50 of 1.7 nM in STING activation and displays the most pronounced antitumor activity via intravenous administration, significantly suppressing tumor proliferation, extending the
Zhiqiang Xie, Huimin Liu, Yuchen Yang, Xiaohan Sun, Jingwen Wang, Tianxiang Liu, Baifan Wang, Wenrui Qiu, Yiwen Sun, Yuting Bai, Yao Zhang, Dejun Ma, Rong Xiang, Shibo Li, Zhen Xi   +14 more
wiley   +1 more source

Toward vanadium-mediated alkyne metathesis. [PDF]

Chem Sci
Hernandez S, Krivovicheva V, Sousa-Silva A, Solans-Monfort X, Bukhryakov KV.   +4 more
europepmc   +1 more source

Supramolecular Polymer‐Surfactant Co‐Assemblies for Multivalent HSV‐1 Inhibition

Angewandte Chemie, EarlyView.
Non‐covalent co‐assembly of BTA with antiviral surfactants produces ratio‐dependent morphologies. Fibrous supramolecular polymers exhibit superior HSV‐1 inhibition, revealing multivalent fiber‐virus interactions and highlighting supramolecular co‐assemblies as a powerful strategy for functional biomedical nanomaterials with demonstrated tunable ...
Christian Zoister, Boris Schade, Paulina Sittinger, Xianwen Lou, Esmee de Korver, Freek V. de Graaf, Ranen Etouki, Chuanxiong Nie, Kai Licha, Kai Ludwig, Abhishek Kumar Singh, E. W. Meijer, Rainer Haag   +12 more
wiley   +1 more source

Safe by Design Flow Technology for Diazoacetonitrile Generation and Direct Conversion to Pyrazoles. [PDF]

ChemistryOpen
Bošković D, Loebbecke S, Piscopo CG, Radulescu LJ, Schwarzer M.   +4 more
europepmc   +1 more source

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, EarlyView.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +1 more source