Results 11 to 20 of about 15,723,400 (130)

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Effect of pre-tensioning force on behavior of Buckling Restrained Brace (BRB) supported by double pre-tensioning system

Fracture and Structural Integrity
The study explores the feasibility of a new all-steel buckling restrained brace (BRB) with the double pre-tensioning system as an alternative to conventional concentrically braced frames by using finite element method (ABAQUS program), And to verify ...
Mohamed Selim, Muhammad E. Kamel, Eman Elshamy, Mohamed Emara   +3 more
doaj   +1 more source

Displacement Estimation of Structures With Flag‐Shaped Hysteresis Loops

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT Time‐history analyses were conducted on single‐degree‐of‐freedom (SDOF) systems with flag‐shaped hysteresis loops using a far‐field ground motion suite to estimate peak displacements, Δp, and equivalent deformation cycles, Nc, associated with cumulative displacement demands.
Yudi Zhang, Gregory A. MacRae, Geoffrey W. Rodgers, Shahab Ramhormozian, Charles Clifton, Masoumeh Farshbaf   +5 more
wiley   +1 more source

Seismic Performance of Shaped Steel Tubes

Buildings
Conventional buckling-restrained braces (BRBs) with rectangular steel tube confinement suffer from stress concentration and inefficient material utilization, limiting their seismic performance.
Chengcheng Bao, Yueqiao Piao, Chengyou Ji, Yilin Liu, Liangzhuo Li, Junkai Lu   +5 more
doaj   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Improving Seismic Performance of RC Structures with Innovative TnT BRBs: A Shake Table and Finite Element Investigation

Applied Sciences
Addressing the critical seismic vulnerabilities of reinforced concrete (RC) beam-column joints remains an imperative research priority in earthquake engineering.
Evrim Oyguc, Resat Oyguc, Onur Seker, Abdul Hayir, Jay Shen, Bulent Akbas   +5 more
doaj   +1 more source

Hyperglycemia‐Induced Microglial CTSS Disrupts Blood‐Retinal Barrier Integrity via PAR2‐Dependent Downregulation of Endothelial MFSD2A

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Hyperglycemia induces retinal microglial activation and CTSS upregulation, disrupting microglia‐endothelial crosstalk via PAR2‐dependent MFSD2A suppression. Abnormal activation of microglia amplifies retinal inflammatory cascade, enhances transcytosis, compromises BRB integrity, and accelerates DR progression.
Chengye Xu, Hongxue Li, Qian Xu, Kangqi Zhao, Yangwen Chen, Yan Wang, Wei Zou, Binglin Kuang, Hongyu Kuang   +8 more
wiley   +1 more source

Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond, Ronny Amamoo, Fapianey J. Alexandre, Sewedo B. Ajisegiri, Menaka C. Thounaojam, Pamela M. Martin, Ravirajsinh N. Jadeja   +6 more
wiley   +1 more source

Sensitivity analysis of steel frames equipped with BRBs

, 2011
Buckling-restrained braces (BRBs) represent a major improvement compared to conventional braces in terms of cyclic inelastic deformation capacity. However, buckling restrained braced frames may undergo large inelastic storey drifts without the ability to
L. RAGNI, ZONA, Alessandro, DALL'ASTA, Andrea   +2 more
core   +1 more source