Results 11 to 20 of about 1,486,266 (226)

High-Throughput MICA/B Genotyping of Over Two Million Samples: Workflow and Allele Frequencies

Frontiers in Immunology, 2020
MICA and MICB are ligands of the NKG2D receptor and thereby influence NK and T cell activity. MICA/B gene polymorphisms, expression levels and the amount of soluble MICA/B in the serum have been linked to autoimmune diseases, infections, and cancer.
Anja Klussmeier, Carolin Massalski, Kathrin Putke, Gesine Schäfer, Jürgen Sauter, Daniel Schefzyk, Jens Pruschke, Jan Hofmann, Daniel Fürst, Daniel Fürst, Raphael Carapito, Seiamak Bahram, Alexander H. Schmidt, Alexander H. Schmidt, Vinzenz Lange   +14 more
doaj   +1 more source

Significant Implications of APOA1 Gene Sequence Variations and Its Protein Expression in Bladder Cancer

Biomedicines, 2021
Apolipoprotein A1 (APOA1) is a potential biomarker because of its variable concentration in different types of cancers. The current study is the first of its kind to evaluate the association between the APOA1 genotypes of −75 G/A and +83 C/T in tandem ...
Javid A. Magray, Arshad A. Pandith, Iqbal Qasim, Muzzain Khateeb, Arif Hamid, Aabid Koul, Zafar A. Shah, Shahid M. Baba, Sheikh Mansoor, Wafa Charifi, Ajaz Ahmad, Mohammad S. Wani   +11 more
doaj   +1 more source

Determination of the association of some polymorphisms with metabolic syndrome in residents of the city of Nur-Sultan [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2021
Aim: Metabolic syndrome develops as a result of a combined effect of environmental factors and genetics. Therefore, this study is an attempt to detect polymorphisms that influence the development of metabolic syndrome among people of reproductive age in ...
Kamshat Akhmetova, Tamara Vochshenkova, Erbolat Dalenov, Aigul Abduldayeva, Talapbek Azhenov   +4 more
doaj   +1 more source

Genetic Variation and Population Differentiation in the Bovine Lymphocyte Antigen DRB3.2 Locus of South African Nguni Crossbred Cattle

Animals, 2021
The bovine lymphocyte antigen (BoLA-DRB3) gene is an important region that codes for glycoproteins responsible for the initiation of an immune response.
Lwamkelekile Sitshilelo Mkize, Oliver Tendayi Zishiri   +1 more
doaj   +1 more source

Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage. [PDF]

, 2019
One fundamental but understudied mechanism of gene regulation in disease is allele-specific expression (ASE), the preferential expression of one allele.
A Chess, A de la Chapelle, A Gimelbrant, A Hogart, A McKenna, A Mortazavi, AA Adegbola, AL Oberg, AM Veerappa, B DeVeale, B Howie, B Langmead, B Tycko, C Fuchsberger, C Gicquel, C Gregg, C Lee, CA de Leeuw, CCY Wong, Changhoon Lee, Cross-Disorder Group of the Psychiatric Genomics Consortium., D Kim, Daniel H. Geschwind, DH Geschwind, E Ben-David, E Eden, E Eden, E Gardiner, EH Cook Jr., Eleazar Eskin, EM Quinn, Eun Yong Kang, EY Kang, F Supek, GT Consortium, GV Kryukov, H Li, HA Scoles, I Iossifov, I Voineagu, J Cavaille, J Cavaille, J Grove, JC Darnell, JF Degner, JK Pickrell, KR Kukurba, M Elsabbagh, M Meguro-Horike, Michael J. Gandal, N Mukherjee, NN Parikshak, NN Parikshak, PH Sudmant, PS Bazeley, R Karlic, S Anders, S Kehr, S Kishore, S Nardone, S Purcell, Schizophrenia Working Group of the Psychiatric Genomics Consortium., SE Castel, SJ Sanders, SM Weyn-Vanhentenryck, T Hulsen, V Savova, Y Zhang, YE Wu   +68 more
core   +1 more source

Understanding Cancer Through the Lens of Epigenetic Inheritance, Allele-Specific Gene Expression, and High-Throughput Technology

Frontiers in Oncology, 2019
Epigenetic information is characterized by its stable transmission during mitotic cell divisions and plasticity during development and differentiation. This duality is in contrast to genetic information, which is stable and identical in all cells in an ...
Maxwell P. Lee
doaj   +1 more source

Frequency changes in HLA‐I alleles: A marker to guide immunotherapy in lung adenocarcinoma patients and its relationship with tumor mutational burden and PD‐L1 expression

Thoracic Cancer, 2023
Background The aim of the study was to investigate differences in HLA‐I alleles between lung adenocarcinoma patients and healthy controls and determine their association with PD‐L1 expression and tumor mutational burden (TMB) to understand the mechanism ...
Xuanpeng Wu, Hao Wang, Fei Xue, Tao Jiang, Nanzheng Chen, Tianju Wang, Yong Zhang, Guangjian Zhang, Junke Fu, Qifei Wu   +9 more
doaj   +1 more source

HLA-A and -B alleles and haplotypes in hemochromatosis probands with HFE C282Y homozygosity in central Alabama

BMC Medical Genetics, 2002
Background We wanted to quantify HLA-A and -B allele and haplotype frequencies in Alabama hemochromatosis probands with HFE C282Y homozygosity and controls, and to compare results to those in other populations.
Barton James C, Acton Ronald T
doaj   +1 more source

Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele.

New England Journal of Medicine, 2019
BACKGROUND Cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein, and nearly 90% of patients have at least one copy of the Phe508del CFTR mutation.
P. Middleton, M. Mall, P. Dřevínek, L. Lands, E. McKone, Deepika Polineni, B. Ramsey, J. Taylor-Cousar, E. Tullis, F. Vermeulen, G. Marigowda, C. Mckee, S. Moskowitz, N. Nair, J. Savage, C. Simard, S. Tian, D. Waltz, F. Xuan, S. Rowe, R. Jain   +20 more
semanticscholar   +1 more source

Polymorphism study of HLA-A, B, DRB1 alleles in patients with chronic renal failure, in Shandong Peninsula

Zhongguo shuxue zazhi, 2022
Objective To investigate the association between HLA-A, B, DRB1 alleles and chronic renal failure (CRF) in Han population of Shandong Peninsula. Methods Sequence specific oligonucleotide probe-polymerase chain reaction (PCR-SSO) was used to genotype 880 ...
Rong WANG, Shumin CHEN, Changfeng SHAO, Qiang JU, Ping LI, Haiyan WANG   +5 more
doaj   +1 more source