Are minor alleles more likely to be risk alleles? [PDF]
BMC Medical Genomics, 2018 Genome-wide association studies (GWASs) have revealed relationships between over 57,000 genetic variants and diseases. However, unlike Mendelian diseases, complex diseases arise from the interplay of multiple genetic and environmental factors. Natural selection has led to a high tendency of risk alleles to be enriched in minor alleles in Mendelian ...
Kido, Takashi +10 more
openaire +6 more sources
Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage. [PDF]
, 2019 One fundamental but understudied mechanism of gene regulation in disease is allele-specific expression (ASE), the preferential expression of one allele.
A Chess +68 more
core +1 more source
Assortative human pair-bonding for partner ancestry and allelic variation of the dopamine receptor D4 (DRD4) gene [PDF]
, 2008 The 7R allele of the dopamine receptor D4 gene has been associated with attention-deficit hyperactivity disorder and risk taking. On the cross-population scale, 7R allele frequencies have been shown to be higher in populations with more of a history of ...
Anna Dreber +15 more
core +3 more sources
Allelic diversity of S-RNase alleles in diploid potato species [PDF]
Theoretical and Applied Genetics, 2016 The S-ribonuclease sequences of 16 S-alleles derived from diploid types of Solanum are presented. A phylogenetic analysis and partial phenotypic analysis support the conclusion that these are functional S-alleles. S-Ribonucleases (S-RNases) control the pistil specificity of the self-incompatibility (SI) response in the genus Solanum and several other ...
Daniel Dzidzienyo +5 more
openaire +5 more sources
Alcohol-related expectancies are associated with the D2 dopamine receptor and GABAa receptor B3 subunit genes [PDF]
, 2004 Molecular genetic research has identified promising markers of alcohol dependence, including alleles of the D2 dopamine receptor (DRD2) and the GABAA receptor ￢3 subunit (GABRB3) genes.
Bandura +87 more
core +2 more sources
Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi. [PDF]
, 2015 Gene knockout strategies, RNAi and rescue experiments are all employed to study mammalian gene function. However, the disadvantages of these approaches include: loss of function adaptation, reduced viability and gene overexpression that rarely matches ...
Dowdy, Steven F +5 more
core +1 more source
Notes on the Genetics of \u3ci\u3ePhymatodes Testaceus\u3c/i\u3e (Coleoptera: Cerambycidae) [PDF]
, 2017 Phenotype ratio for elytral coloration among reared offspring of Phymatodes testaceus suggests that this trait is controlled by a single gene with a dominant allele producing brown elytra and a reeessive allele for blue elytra. The brown-elytra phenotype
Gosling, D. C. L
core +2 more sources
A Novel PCR-Based Functional Marker of Rice Blast Resistance Gene Pi25
Agriculture, 2023 Rice blast is arguably the most devastating fungal disease of rice. Utilization of resistance genes to breed resistant cultivars is one of the most economical and environmentally friendly approaches to combat the disease.
Yeyang Fan +6 more
doaj +1 more source
Use of allele specific PCR to investigate the presence of β-casein polymorphism in Holstein-Friesian cows [PDF]
Veterinarski Glasnik, 2022 Following the “one health” principle, we have conducted optimization of a protocol for β-casein genotyping in cattle in order to select cows with exclusively the A2A2 genotype.
Ristanić Marko +6 more
doaj +1 more source
Correction to the pathogenic alternative splicing, caused by the common GNB3 c.825C>T allele, using a novel, antisense morpholino [PDF]
, 2016 The very common GNB3 c.825C>T polymorphism (rs5443), is present in approximately half of all human chromosomes. Significantly the presence of the GNB3 825T allele has been strongly associated, with predisposition to essential hypertension ...
Lester, Douglas H. +2 more
core +3 more sources