Results 11 to 20 of about 427,317 (231)

Are minor alleles more likely to be risk alleles? [PDF]

BMC Medical Genomics, 2018
Genome-wide association studies (GWASs) have revealed relationships between over 57,000 genetic variants and diseases. However, unlike Mendelian diseases, complex diseases arise from the interplay of multiple genetic and environmental factors. Natural selection has led to a high tendency of risk alleles to be enriched in minor alleles in Mendelian ...
Kido, Takashi, Sikora-Wohlfeld, Weronika, Kawashima, Minae, Kikuchi, Shinichi, Kamatani, Naoyuki, Patwardhan, Anil, Chen, Richard, Sirota, Marina, Kodama, Keiichi, Hadley, Dexter, Butte, Atul J   +10 more
openaire   +5 more sources

Significant Implications of APOA1 Gene Sequence Variations and Its Protein Expression in Bladder Cancer

Biomedicines, 2021
Apolipoprotein A1 (APOA1) is a potential biomarker because of its variable concentration in different types of cancers. The current study is the first of its kind to evaluate the association between the APOA1 genotypes of −75 G/A and +83 C/T in tandem ...
Javid A. Magray, Arshad A. Pandith, Iqbal Qasim, Muzzain Khateeb, Arif Hamid, Aabid Koul, Zafar A. Shah, Shahid M. Baba, Sheikh Mansoor, Wafa Charifi, Ajaz Ahmad, Mohammad S. Wani   +11 more
doaj   +1 more source

Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage. [PDF]

, 2019
One fundamental but understudied mechanism of gene regulation in disease is allele-specific expression (ASE), the preferential expression of one allele.
A Chess, A de la Chapelle, A Gimelbrant, A Hogart, A McKenna, A Mortazavi, AA Adegbola, AL Oberg, AM Veerappa, B DeVeale, B Howie, B Langmead, B Tycko, C Fuchsberger, C Gicquel, C Gregg, C Lee, CA de Leeuw, CCY Wong, Changhoon Lee, Cross-Disorder Group of the Psychiatric Genomics Consortium., D Kim, Daniel H. Geschwind, DH Geschwind, E Ben-David, E Eden, E Eden, E Gardiner, EH Cook Jr., Eleazar Eskin, EM Quinn, Eun Yong Kang, EY Kang, F Supek, GT Consortium, GV Kryukov, H Li, HA Scoles, I Iossifov, I Voineagu, J Cavaille, J Cavaille, J Grove, JC Darnell, JF Degner, JK Pickrell, KR Kukurba, M Elsabbagh, M Meguro-Horike, Michael J. Gandal, N Mukherjee, NN Parikshak, NN Parikshak, PH Sudmant, PS Bazeley, R Karlic, S Anders, S Kehr, S Kishore, S Nardone, S Purcell, Schizophrenia Working Group of the Psychiatric Genomics Consortium., SE Castel, SJ Sanders, SM Weyn-Vanhentenryck, T Hulsen, V Savova, Y Zhang, YE Wu   +68 more
core   +1 more source

Genetic Variation and Population Differentiation in the Bovine Lymphocyte Antigen DRB3.2 Locus of South African Nguni Crossbred Cattle

Animals, 2021
The bovine lymphocyte antigen (BoLA-DRB3) gene is an important region that codes for glycoproteins responsible for the initiation of an immune response.
Lwamkelekile Sitshilelo Mkize, Oliver Tendayi Zishiri   +1 more
doaj   +1 more source

Use of allele specific PCR to investigate the presence of β-casein polymorphism in Holstein-Friesian cows [PDF]

Veterinarski Glasnik, 2022
Following the “one health” principle, we have conducted optimization of a protocol for β-casein genotyping in cattle in order to select cows with exclusively the A2A2 genotype.
Ristanić Marko, Nikšić Aleksandar, Niketić Mia, Jelisić Stefan, Rajković Milan Z., Glavinić Uroš, Stanimirovic Zoran   +6 more
doaj   +1 more source

Allelic diversity of S-RNase alleles in diploid potato species [PDF]

Theoretical and Applied Genetics, 2016
The S-ribonuclease sequences of 16 S-alleles derived from diploid types of Solanum are presented. A phylogenetic analysis and partial phenotypic analysis support the conclusion that these are functional S-alleles. S-Ribonucleases (S-RNases) control the pistil specificity of the self-incompatibility (SI) response in the genus Solanum and several other ...
Daniel Dzidzienyo, Daniel Dzidzienyo, Daniel Dzidzienyo, Gail Wilde, Glenn J. Bryan, T. P. Robbins   +5 more
openaire   +5 more sources

Understanding Cancer Through the Lens of Epigenetic Inheritance, Allele-Specific Gene Expression, and High-Throughput Technology

Frontiers in Oncology, 2019
Epigenetic information is characterized by its stable transmission during mitotic cell divisions and plasticity during development and differentiation. This duality is in contrast to genetic information, which is stable and identical in all cells in an ...
Maxwell P. Lee
doaj   +1 more source

HLA-A and -B alleles and haplotypes in hemochromatosis probands with HFE C282Y homozygosity in central Alabama

BMC Medical Genetics, 2002
Background We wanted to quantify HLA-A and -B allele and haplotype frequencies in Alabama hemochromatosis probands with HFE C282Y homozygosity and controls, and to compare results to those in other populations.
Barton James C, Acton Ronald T
doaj   +1 more source

Frequency changes in HLA‐I alleles: A marker to guide immunotherapy in lung adenocarcinoma patients and its relationship with tumor mutational burden and PD‐L1 expression

Thoracic Cancer, 2023
Background The aim of the study was to investigate differences in HLA‐I alleles between lung adenocarcinoma patients and healthy controls and determine their association with PD‐L1 expression and tumor mutational burden (TMB) to understand the mechanism ...
Xuanpeng Wu, Hao Wang, Fei Xue, Tao Jiang, Nanzheng Chen, Tianju Wang, Yong Zhang, Guangjian Zhang, Junke Fu, Qifei Wu   +9 more
doaj   +1 more source

Assortative human pair-bonding for partner ancestry and allelic variation of the dopamine receptor D4 (DRD4) gene [PDF]

, 2008
The 7R allele of the dopamine receptor D4 gene has been associated with attention-deficit hyperactivity disorder and risk taking. On the cross-population scale, 7R allele frequencies have been shown to be higher in populations with more of a history of ...
Anna Dreber, Asghari, Benjamin C. Campbell, Boom, Coren L. Apicella, Dan T. A. Eisenberg, Eisenberg, Feigelson, Gal, Hutchison, J. Koji Lum, Justin R. Garcia, Lucentini, Matsumoto, Rebollo, Watts   +15 more
core   +3 more sources