Results 51 to 60 of about 1,486,266 (226)
WASP: allele-specific software for robust molecular quantitative trait locus discovery
Nature Methods, 2015 Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), but they are challenging to analyze and are prone to technical artifacts.
Bryce van de Geijn +3 more
semanticscholar +1 more source
SNPsplit: Allele-specific splitting of alignments between genomes with known SNP genotypes
F1000Research, 2016 Sequencing reads overlapping polymorphic sites in diploid mammalian genomes may be assigned to one allele or the other. This holds the potential to detect gene expression, chromatin modifications, DNA methylation or nuclear interactions in an allele ...
Felix Krueger, S. Andrews
semanticscholar +1 more source
Selection Mapping Identifies Loci Underpinning Autumn Dormancy in Alfalfa (Medicago sativa). [PDF]
, 2018 Autumn dormancy in alfalfa (Medicago sativa) is associated with agronomically important traits including regrowth rate, maturity, and winter survival. Historical recurrent selection experiments have been able to manipulate the dormancy response.
Brummer, E Charles +3 more
core +3 more sources
Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9.
Human Molecular Genetics, 2016 A comprehensive genetics-based precision medicine strategy to selectively and permanently inactivate only mutant, not normal allele, could benefit many dominantly inherited disorders.
Jun Wan Shin +7 more
semanticscholar +1 more source
Transcriptome Reveals Allele Contribution to Heterosis in Maize
Frontiers in Plant Science, 2021 Heterosis, which has greatly increased maize yields, is associated with gene expression patterns during key developmental stages that enhance hybrid phenotypes relative to parental phenotypes.
Jianzhong Wu +13 more
doaj +1 more source
CONTRASTING EFFECTS OF AN MDM2 FUNCTIONAL POLYMORPHISM ON TUMOR PHENOTYPES [PDF]
, 2017 Cancer predisposition by the cooperation of genetic variants, such as single nucleotide polymorphisms (SNPs), may be of much greater significance to public health than previously appreciated.
Ortiz, Guadalupe J, IV
core +2 more sources
Scientific Papers Animal Science and Biotechnologies, 2023 New genetic methods are currently used in selection activities of agricultural animals, based on polymorph genetic determination systems, which, serving as genetic markers, enable studying animal genealogy, alelofon, genotypes.
Manvel Badalyan +2 more
doaj
Allele-Specific Isothermal Amplification Method Using Unmodified Self-Stabilizing Competitive Primers. [PDF]
, 2018 Rapid and specific detection of single nucleotide polymorphisms (SNPs) related to drug resistance in infectious diseases is crucial for accurate prognostics, therapeutics and disease management at point-of-care.
Baum, Jake +7 more
core +2 more sources
Plant, Cell and Environment, 2016 Excessive cadmium (Cd) accumulation in rice poses a risk to food safety. OsHMA3 plays an important role in restricting Cd translocation from roots to shoots.
Jiali Yan +8 more
semanticscholar +1 more source
Spatial gene drives and pushed genetic waves
, 2017 Gene drives have the potential to rapidly replace a harmful wild-type allele with a gene drive allele engineered to have desired functionalities. However, an accidental or premature release of a gene drive construct to the natural environment could ...
Nelson, David R. +2 more
core +1 more source