Results 71 to 80 of about 891,020 (314)

Genome-Wide Association Study of Soybean Germplasm Derived From Canadian × Chinese Crosses to Mine for Novel Alleles to Improve Seed Yield and Seed Quality Traits [PDF]

, 2022
Chanditha Priyanatha, Davoud Torkamaneh, Istvan Rajcan   +2 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution Genome evolution and evolutionary systems biology [PDF]

, 2014
© 2014 Janha et al.; licensee BioMed Central Ltd.Background: Cytochrome P450 CYP2C19 metabolizes a wide range of pharmacologically active substances and a relatively small number of naturally occurring environmental toxins.
Janha, RE, Linton, KJ, Shaheen, SO, Sisay-Joof, F, Walton, RT, Worwui, A   +5 more
core   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

GENOTYPES AND PHENOTYPES OF ALZHEIMER’S DISEASE

Наука и инновации в медицине, 2018
Aim - research of gene APOE for definition of allele structures of the human population phenotypes resulting in risk of Alzheimer’s disease. Materials and methods. Use of the Hardy-Weinberg theory and statistical researches of the alleles distribution of
AN N Volobuev, VF F Pyatin, NP P Romanchuk, NN N Aleksandrova   +3 more
doaj   +1 more source

Autosegregation of enzyme loci Me1 and Gpi2 in agamospermous progenies of triploid sugarbeet plants [PDF]

, 2010
Ratios of malic-enzyme (ME1) and glucosephosphate isomerase (GPI2) phenotypic classes were studied in agamospermous progenies of triploid sugar beet plants.
Evgenii Levites, Svetlana Kirikovich
core   +1 more source

Alcohol-related expectancies are associated with the D2 dopamine receptor and GABAa receptor B3 subunit genes [PDF]

, 2004
Molecular genetic research has identified promising markers of alcohol dependence, including alleles of the D2 dopamine receptor (DRD2) and the GABAA receptor ￢3 subunit (GABRB3) genes.
Bandura, Bandura, Bau, Berman, Berridge, Blomqvist, Blum, Bruce R Lawford, Christiansen, Cohen, Comings, Connor, Connor, David, Davies, Depue, DiChiara, DiChiara, DiChiara, DiChiara, Dimitrov, Duan, Dudek, Ernest P Noble, Feeney, Gelernter, Gerald F.X Feeney, Goldman, Grandy, Greenfield, Gurling, Hitzemann, Hollerman, Ikemoto, Jönsson, Kidd, Knight, Laruelle, Lawford, Lawford, Lawford, Lawford, Long, Luddens, Madrid, Maldonado, McCarthy, McCarthy, Miller, Monti, Mutirangura, Neiswanger, Noble, Noble, Noble, Noble, Noble, Noble, Noble, Noble, Noone, Ott, Pato, Persico, Pohjalainen, Robinson, Ross McD Young, Schultz, Schultz, Selzer, Silvestri, Spitz, Terry Ritchie, Thanos, Thompson, Uhl, Vernon, Vik, Volkow, Volkow, Wells-Parker, Williams, Wilson, Wise, Young, Young, Young, Young   +87 more
core   +2 more sources

Genome-wide superior alleles, haplotypes and candidate genes associated with tolerance on sodic-dispersive soils in wheat (Triticum aestivum L.) [PDF]

, 2022
Darshan Sharma, Roopali Bhoite, Karyn Reeves, Kerrie Forrest, Rosemary H Smith, Mirza A. N. N. U. Dowla   +5 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Polimorfismos reguladores y su participación en la patogenia de enfermedades complejas en la era posgenómica Polymorphisms in gene regulatory regions and their role in the physiopathology of complex disease in the post-genomic era

Salud Pública de México, 2009
El estudio de la participación de la variación genética en la predisposición a las enfermedades complejas ha cobrado nuevas dimensiones en la era genómica.
Jesús Hernández-Romano, Jesús Martínez-Barnetche, Verónica Valverde-Garduño   +2 more
doaj