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Multiomics approaches disclose very-early molecular and cellular switches during insect-venom allergen-specific immunotherapy

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Hefeng F   +40 more
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Allergen-Specific Immunotherapy

2014
Specific immunotherapy was introduced for the treatment of grass pollen-induced hay fever in 1911. The treatment was soon extended to other pollens as well as perennial allergens, and to the treatment of bronchial asthma. Definitive studies of its efficacy for both rhinitis and asthma came only many decades later. Understanding gradually emerged of the
Harold S, Nelson, Philip S, Norman
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Allergen-specific immunotherapy

Immunology Letters, 2009
Allergy is a significant health problem in industrialized countries and its prevalence is continually on the increase: In 1906, when Clemens von Pirquet introduced the term "allergy" to describe overwhelming pathological reactions of the body caused by contact with antigens, less than 1% of the population were affected.
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Advances in Allergen-Specific Immunotherapy

Current Drug Targets, 2009
After several decades of controversies, allergen specific immunotherapy (SIT) was recognized as an effective treatment for respiratory and hymenoptera allergy by the World Health Organization in 1998. SIT involves the administration (usually subcutaneous) of increasing doses of allergen in order to achieve a hyposensitization. Moreover, SIT is the only
PASSALACQUA, GIOVANNI   +2 more
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Advances in allergen-specific immunotherapy

Expert Opinion on Biological Therapy, 2005
Atopic disease affects approximately 30% of the population in western society. Allergen-specific immunotherapy (SIT) is the only treatment with a long-term effect available at the present time, and has been used successfully in the treatment of a number of allergies for almost 100 years. Despite this success, there is great demand for safer, faster and
Johan, Verhagen   +3 more
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Regulatory Cells in Allergen-Specific Immunotherapy

Immunotherapy, 2012
Allergen-specific immunotherapy (SIT) is currently the best available curative treatment in allergies and has been used for the treatment of patients for the past 100 years. The formation of a Th2 cell predominant inflammation in addition to production of allergen-specific IgE, the attraction of proinflammatory cells and the degranulation of effector ...
Soyka, M B, Holzmann, D, Akdis, C A
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Allergen-Specific Immunotherapy (ASIT)

2019
The reader can find the up-to-date information on allergens and their nomenclature, subcutaneous and sublingual methods of allergen-specific therapy (ASIT), mechanisms of action of ASIT, clinical efficacy, etc. There is an explanation why the ASIT as a modality of treatment for atopic allergic conditions is more important and be predominant in the near
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Standards for practical allergen‐specific immunotherapy

Allergy, 2006
Foreword The paper was drafted by Emilio Alvarez-Cuesta (chairman), Spain, Jean Bousquet, France, G Walter Canonica, Italy, Stephen Durham, England, Hans-Jorgen Mailing, Denmark and Erkka Valovirta, Finland. The paper was revised and input added by a European Reference Group, endorsed by National Societies associated EAACI and approved by the Executive
Alvarez Cuesta E   +6 more
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Immunologic mechanisms of allergen-specific immunotherapy

2001
Allergic diseases basically are immunological disorders, related to activation of a distinct cytokine pattern in T cells, including increased secretion of certain allergic inflammatory cytokines, in particular of IL-4, IL-5 and/or IL-13. (1-3).
C A, Akdis, K, Blaser
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