Results 161 to 170 of about 120,561 (245)

Biologics and Small‐Molecule Therapies in Netherton Syndrome: A Comprehensive Review

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT Netherton syndrome (NS) is a rare congenital ichthyosis caused by loss‐of‐function mutations in the SPINK5 gene, leading to defective expression of the serine protease inhibitor LEKTI. Dysregulated epidermal protease activity results in impaired skin barrier function and chronic inflammation, accompanied by complex immune profiles. NS patients
Shin Morizane   +6 more
wiley   +1 more source

Beyond the numbers: Critical analysis of the role of postmortem tryptase in the forensic diagnosis of anaphylaxis

open access: yesJournal of Forensic Sciences, EarlyView.
Abstract The postmortem diagnosis of anaphylaxis remains a forensic challenge due to the lack of specific external signs. Tryptase, a mast cell‐derived protease, has emerged as a potential biomarker for fatal anaphylaxis. This systematic review critically examined 40 studies published between 2014 and 2024, including both biochemical and ...
Luca Tomassini   +8 more
wiley   +1 more source

Global parent perspectives on school food service internationally: A mixed papers narrative review

open access: yesNutrition &Dietetics, EarlyView.
Abstract Aims The views of parents/caregivers about food programs in schools internationally is not well understood. This review aimed to synthesise what parents/caregivers identify as the key features of school food programs and their perspectives of these programs globally.
Alexandra C. Manson   +2 more
wiley   +1 more source

Healthy Meals 4 Kids: A Four‐Part Instructional Case*

open access: yesAccounting Perspectives, EarlyView.
Abstract This fictional case centers on a not‐for‐profit organization, Healthy Meals 4 Kids, in the province of New Brunswick, Canada, that provides free meals to families experiencing financial difficulty who have children with special dietary needs. The case provides an opportunity for students to perform many tasks related to external auditing—using
Bryce Cross, Samantha Taylor
wiley   +1 more source

Breast and Nipple Dermatoses During Lactation

open access: yesAustralasian Journal of Dermatology, EarlyView.
ABSTRACT Lactation and breastfeeding can present both psychological and physical challenges for breastfeeding mothers. In addition, many nursing mothers will also suffer from breast and nipple dermatoses during this period, compounding these difficulties. Common causes of breast and nipple dermatitis during lactation include eczema, psoriasis, mastitis,
Hamish Moore, Annabel Stevenson
wiley   +1 more source

Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, CDX‐622

open access: yesAllergy, EarlyView.
SCF and TSLP expression are known to drive unique immune responses leading to the onset of allergic and inflammatory diseases. Here, we describe the characterization of a novel bsAb, CDX‐622, that targets SCF and TSLP. CDX‐622 inhibits MC functions through SCF starvation and Type 2 inflammatory responses via TSLP inhibition.
Michael B. Murphy   +17 more
wiley   +1 more source

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