Results 251 to 260 of about 180,280 (304)
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Recombinant allergens/ allergen standardization
Current Allergy and Asthma Reports, 2001Recombinant allergens are genetically engineered isoforms representing allergen molecules from allergen extracts. Immunologic responses of allergic patients toward allergen extracts define the major allergens. For the average allergic patient, the diagnostic sensitivity and treatment efficacy correlate with the concentration of major allergen ...
H, Løwenstein, J N, Larsen
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Allergy, allergens and allergen standardization
Medical Journal of Australia, 1984Immediate, type 1 allergic reactions occur following interaction between allergen, immunoglobulin E (IgE), and the mast cell or basophil. Allergen-induced activation of these cells leads to the release of a number of mediators that are responsible for the symptoms observed during an allergic reaction.
B A, Baldo, E R, Tovey
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Clinical Reviews in Allergy & Immunology, 2001
What makes an antigen an allergen? This question has been at the core of much research regarding the basic mechanisms of allergy as well as the development of diagnostic and therapeutic allergen products. Great strides have been made since Kjell Aas asked this question in his classic review in Allergy (1), but we appear no closer to the answer.
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What makes an antigen an allergen? This question has been at the core of much research regarding the basic mechanisms of allergy as well as the development of diagnostic and therapeutic allergen products. Great strides have been made since Kjell Aas asked this question in his classic review in Allergy (1), but we appear no closer to the answer.
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Primary Care: Clinics in Office Practice, 1987
The environment contains a huge array of allergens, primarily proteins or glycoproteins, to which the atopic individual may become sensitized. In situations of high exposure and highly reactive substances, even nonatopic individuals may develop allergic antibodies.
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The environment contains a huge array of allergens, primarily proteins or glycoproteins, to which the atopic individual may become sensitized. In situations of high exposure and highly reactive substances, even nonatopic individuals may develop allergic antibodies.
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2005
Allergy affects more than 25% of Western populations (1) and is estimated to be the sixth leading cause of chronic disease in the United States and Western Europe. The complexity of the condition is such that hundreds of common allergens have been described, and in order to maximize diagnostic efficiency there is an urgent clinical requirement for ...
Bacarese Hamilton T. +3 more
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Allergy affects more than 25% of Western populations (1) and is estimated to be the sixth leading cause of chronic disease in the United States and Western Europe. The complexity of the condition is such that hundreds of common allergens have been described, and in order to maximize diagnostic efficiency there is an urgent clinical requirement for ...
Bacarese Hamilton T. +3 more
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Updates on Databases of Allergens and Allergen-Epitopes
2023The increasing prevalence of allergic diseases is of great public health concern. Environmental and food allergens are the major triggers of allergic diseases via respiratory or gastrointestinal routes, respectively. A major setback in the clinical management of allergies is the unavailability of purified allergens required for diagnostic purposes ...
Rajat Kanti, Sarkar +3 more
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Factors Influencing the Allergenicity and Adjuvanticity of Allergens
Immunotherapy, 2011IgE-mediated allergic disorders affect up to 25% of the population in industrialized countries and result in a Th2-polarized immune response to innocuous environmental proteins, so-called allergens. Among a large number of proteins to which humans are exposed to, only a minute fraction are allergens.
Stephan, Deifl, Barbara, Bohle
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Standardized allergen extracts for allergen immunotherapy
Allergy and Asthma Proceedings, 2022Nineteen U.S. allergen extracts were standardized by the U.S. Food and Drug Administration (FDA) between 1987 and 1998, including of two house-dust mites, short ragweed, cat hair and cat pelt, seven temperate and one southern grass, and six Hymenoptera venom preparations. Relevant literature was reviewed.
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Allergen databases and allergen semantics
Regulatory Toxicology and Pharmacology, 2009The efficacy of any specific bioinformatic analysis of the potential allergenicity of new food proteins depends directly on the nature and content of the databases that are used in the analysis. A number of different allergen-related databases have been developed, each designed to meet a different need.
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Cockroach Allergens: Function, Structure and Allergenicity
Protein & Peptide Letters, 2007Cockroach allergy is a widespread health problem in the world, associated with the development of asthma. The German and American cockroach species are important producers of a wide variety of allergens. Knowledge of their structure and function contributes to understand their role in allergy and to design tools for diagnosis and immunotherapy.
A, Pomés +4 more
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