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Update on Allergen Immunotherapy

Veterinary Clinics of North America: Small Animal Practice, 2019
Allergen immunotherapy has been used for many years in dogs and cats and is the only specific treatment of atopic dermatitis that changes the patho-mechanisms of disease by stimulating allergen tolerance. Subcutaneous administration of allergens is the most commonly used administration route, typically in increasing concentrations (induction period ...
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Allergens and Allergen Immunotherapy

1998
Allergen immonotherapy in historical perpective definition of an allergen aerobiology allergen nomenclature tree pollen allergens grass pollen allergens weed pollen allergens mold allergens biting insect allergens mite allergens cockroach and other inhalent insect allergens food allergens latex allergens drug allergens, haptens and anaphylatoxins ...
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ALLERGEN IMMUNOTHERAPY AND AVOIDANCE

Primary Care: Clinics in Office Practice, 1998
Since its introduction almost a century ago, immunotherapy continues to be an effective method of managing allergic rhinitis, allergic asthma, and insect anaphylaxis. Confusion and misinformation on the part of physicians and the public lead to the inappropriate use of this treatment.
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Engineered allergens for immunotherapy

Current Opinion in Allergy and Clinical Immunology, 2004
Specific immunotherapy is a clinically effective causative treatment for allergic conditions. However, the reagents used for immunotherapy are crude extracts prepared from natural sources with potential life-threatening anaphylactic side effects. Molecular cloning of allergens has made it feasible to design novel therapeutic approaches for improved and
Prem L, Bhalla, Mohan B, Singh
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Standardized allergen extracts for allergen immunotherapy

Allergy and Asthma Proceedings, 2022
Nineteen U.S. allergen extracts were standardized by the U.S. Food and Drug Administration (FDA) between 1987 and 1998, including of two house-dust mites, short ragweed, cat hair and cat pelt, seven temperate and one southern grass, and six Hymenoptera venom preparations. Relevant literature was reviewed.
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Allergen immunotherapy for asthma

2003
Allergen specific immunotherapy has long been a controversial treatment for asthma. Although beneficial effects upon clinically relevant outcomes have been demonstrated in randomised controlled trials, there remains a risk of severe and sometimes fatal anaphylaxis.
M J, Abramson, R M, Puy, J M, Weiner
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Recombinant allergens for immunotherapy

Journal of Allergy and Clinical Immunology, 2007
Recombinant allergens can be produced as defined molecules in consistent quality and unlimited amounts according to the corresponding DNA template. Furthermore, they can be modified to reduce their allergenic activity and to foster certain advantageous immunologic properties.
Rudolf, Valenta, Verena, Niederberger
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Allergen-specific immunotherapy

Immunology Letters, 2009
Allergy is a significant health problem in industrialized countries and its prevalence is continually on the increase: In 1906, when Clemens von Pirquet introduced the term "allergy" to describe overwhelming pathological reactions of the body caused by contact with antigens, less than 1% of the population were affected.
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Recombinant Allergens for Immunotherapy

1996
Starting with Der p 1 (1,2) from the mite and Dol m 5 (3) from the hornet the u-biquitous allergens are rapidly being cloned. These include Bet v 1, 2 and 3 from birch (4–6) and the allergens from related trees, the group 1 and 5 allergens from timothy (7, 8) and perennial rye (9–11) and group 5/9 from Kentucky blue grass (12, 13).
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Allergen Immunotherapy

Drugs, 1990
Allergen immunotherapy is a safe and effective adjunct to treatment when applied to selected patients with IgE-mediated disease,using appropriately chosen,well defined allergens.
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