Results 41 to 50 of about 30,567 (270)

Integrating Human Intestinal Organoids into FDA'S New Approach Methodologies for Drug Discovery

Advanced Science, EarlyView.
Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu   +6 more
wiley   +1 more source

Allergen-specific immunotherapy in the treatment of bronchial asthma in children

Zdorovʹe Rebenka, 2019
The article presents a review of the literature that analyses the current possibilities and benefits of allergen-specific immunotherapy in children with bronchial asthma. Bronchial asthma has a leading place in the structure of allergic pathology.
L.V. Besh, Z.L. Slyuzar
doaj   +1 more source

Nanoparticle–allergen complexes for allergen immunotherapy

International Journal of Nanomedicine, 2017
Allergen-specific immunotherapy was introduced in clinical settings more than 100 years ago. It remains the only curative approach to treating allergic disorders that ameliorates symptoms, reduces medication costs, and blocks the onset of new sensitizations.
Paolo Colombo, Gabriella Di Felice
openaire   +5 more sources

Local Specific IgE Levels Can Predict and Monitor the Therapeutic Response to Subcutaneous Immunotherapy With House Dust Mite

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Identifying predictive and monitoring biomarkers for allergen immunotherapy response is crucial for enhancing clinical efficacy. This study aims to investigate the systemic and local levels of immunoglobulins and identify potential biomarkers in house dust mite (HDM) allergic rhinitis (AR) patients who are undergoing subcutaneous ...
Xu Xu, Jingyun Li, Xu Zhang, Yu Song, Lin Xi, Luo Zhang, Yuan Zhang   +6 more
wiley   +1 more source

Local side effects during sublingual allergen-specific immunotherapy and pathogenetically based methods for their correction (Review)

Аллергология и Иммунология в Педиатрии
Introduction. The study of the effectiveness and safety of allergen-specific immunotherapy remains relevant due to the emergence of a personalized approach in allergology and new dosage forms.
V. Ya. Zakurskaya
doaj   +1 more source

Recent advances in food allergen immunotherapy [PDF]

Clinical and Experimental Pediatrics
Food allergies can pose significant risks and profoundly impact the quality of life of children and their families, making them a major public health concern. Allergen avoidance has been the traditional mainstay of treatment; however, recent research has
You Hoon Jeon, Edwin H. Kim
doaj   +1 more source

Rationale of New Grading System: Central Compartment Atopic Disease

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Central compartment atopic disease (CCAD) has recently been recognized as a distinct phenotype within the spectrum of type 2–dominant chronic rhinosinusitis (CRS). Although international guidelines highlight polypoid changes in the central nasal cavity, standardized diagnostic and classification criteria are still lacking.
Ramón Moreno‐Luna, Carmen Palma‐Martínez, Serafin Sánchez‐Gómez, Isam Alobid, Daniel Martin‐Jimenez, José Miguel Villacampa‐Aubá, Christian Calvo‐Henríquez, Alfonso Del Cuvillo, Alfonso Santamaría‐Gadea, Jaime González‐García, Richard J. Harvey, John M. DelGaudio   +11 more
wiley   +1 more source

Frequency of new sensitization in patients experiencing symptom recurrence during allergen immunotherapy

Egyptian Journal of Chest Disease and Tuberculosis
Introduction Allergen immunotherapy should be personalized according to the allergen sensitization pattern and the clinical impact of allergens. Sensitization, or the existence of antibodies for specific allergens, is a necessary step for developing an ...
Eman A. Saied, Mohammed Shehta, Ahmad Y. Badawy, Heba W. Abdelwahab   +3 more
doaj   +1 more source

Establishment of enzyme-linked immunosorbent facilitated antigen binding as a biomarker assay for Japanese cedar pollen allergy immunotherapy

Journal of Pharmacological Sciences, 2019
Background: Clinical efficacy of allergen-specific Immunotherapy (AIT) towards Japanese cedar (JC) pollen allergy is firmly established but JC pollen-specific biomarker assays are lacking.
Chiharu Fukano, Katsuyo Ohashi-Doi, Kaare Lund, Atsuhito Nakao, Keisuke Masuyama, Tomokazu Matsuoka   +5 more
doaj   +1 more source

Allergens, germs and asthma [PDF]

, 2015
Objective To explore asthma pathogenesis using data from upper and lower airways. Data Source English-language papers on human asthma and nasal polyp subjects from 1990 onwards.
Scadding, GK
core